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103 Junk L, Schmiedel VM, Guha S, Fischel K, Greb P, Vill K, Krisilia V, van Geelen L, Rumpel K, Kaur P, Krishnamurthy RV, Narayanan S, Shandil RK, Singh M, Kofink C, Mantoulidis A, Biber P, Gmaschitz G, Kazmaier U, Meinhart A, Leodolter J, Hoi D, Junker S, Morreale FE, Clausen T, Kalscheuer R, Weinstabl H, Boehmelt G. Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria. Nat Commun 15, 2005 (2024).      
102 Anwar A, Elnaggar MS, Elissawy AM, Ibrahim N, Mándi A, Kurtán T, Liu Z, El-Ahmady SH, Kalscheuer R. New Meroterpenoid derivatives from the pomegranate-derived endophytic fungus Talaromyces purpureogenus. Molecules 28, 7650 (2023).    
101 Eze PM, Simons VE, Frank M, van Geelen L, Abba CC, Ebada SS, Esimone CO, Okoye FBC, Proksch P, Kalscheuer R. Serratiochelin D, a new siderophore from Serratia marcescens. Phytochem Lett 57, 22–25 (2023).    
100 Wang L, Kiffe-Delf A-L, Ostermann PN, Simons VE, He D, Gao Y, van Geelen L, Dai H, Zhao Y-X, Schaal H, Mándi A, Király SB, Kurtán T, Liu Z, Kalscheuer R. Asperphenalenones isolated from the biocontrol agent Clonostachys rosea and their antimicrobial activities. J Agric Food Chem 71, 11056-11068 (2023).    
99 Elnaggar MS, Elissawy AM, Youssef FS, Kicsák M, Kurtán T, Singab ANB, Kalscheuer R. Austalide derivative from marine-derived Aspergillus sp. and evaluation of its cytotoxic and ADME/TOPKAT properties. RSC Adv. 13, 16480-16487 (2023).    

Hoi DM, Junker S, Junk L, Schwechel K, Fischel K, Podlesainski D, Hawkins OME, van Geelen L, Kaschani F, Leodolter J, Morreale FE, Kleine S, Guha S, Rumpel K, Schmiedel VM, Weinstabl H, Meinhart A, Payne RJ, Kaiser M, Hartl M, Boehmelt G, Kazmaier U, Kalscheuer R, Clausen T. Development of a dual Clp-targeting BacPROTAC that impairs mycobacterial proteostasis and survival. Cell 186, 2176–2192 (2023).



Eze PM, Liu Y, Simons VE, Ebada SS, Kurtán T, Király SB, Esimone CO, Okoye FBC, Proksch P, Kalscheuer R. Two new metabolites from a marine-derived fungus Penicillium ochrochloron. Phytochem Lett 55, 101-104 (2023).    
96 Liyanage SH, Raviranga NGH, Ryan JG, Shell SS, Ramström O, Kalscheuer R, Yan M. Azide-masked fluorescence turn-on probe for imaging mycobacteria. J Am Chem Soc Au 3, 1017-1028 (2023).    
95 Mazzone F, Simons VE, van Geelen L, Frank M, Mándi A, Kurtán T, Pfeffer K, Kalscheuer R. In vitro biological activity of natural products from the endophytic fungus Paraboeremia selaginellae against Toxoplasma gondii. Antibiotics 11, 1176 (2022).    
94 Berger A, Knak T, Kiffe-Delf AL, Singh V, Njoroge M, Burckhardt BB, Gopalswamy M, Gohlke H, Chibale K, Kalscheuer R, Kurz T. Total synthesis of the antimycobacterial natural product chlorflavonin and analogs via a late-stage ruthenium(II)-catalyzed ortho-C(sp2)-H-hydroxylation. Pharmaceuticals 15, 984 (2022).    
93 Yang X, Ali S, Zhao M, Richter L, Schäfer V, Schliehe-Diecks J, Frank M, Qi J, Larsen PK, Skerra J, Islam H, Wachtmeister T, Alter C, Huang A, Bhatia S, Köhrer K, Kirschning C, Weighardt H, Kalinke U, Kalscheuer R, Uhrberg M, Scheu S. The mycotoxin beauvericin exhibits immunostimulatory effects on dendritic cells via activating the TLR4 signaling pathway. Front Immunol 13, 856230 (2022).    
92 Babu Sait MR, Koliwer Brandl H, Stewart JA, Swarts BM, Jacobsen M, Ioerger TR, Kalscheuer R. PPE51 mediates uptake of trehalose across the mycomembrane of Mycobacterium tuberculosis. Sci Rep 12, 2097 (2022).    
91 Akone SH, Wang H, Mouelle ENM, Mándi A, Kurtán T, Koliye PR, Hartmann R, Bhatia S, Yang J, Müller WEG, Lai D,  Liu Z, Kalscheuer R, Proksch P. Prenylated cyclohexene-type meroterpenoids and sulfur-containing xanthones produced by Pseudopestalotiopsis theae. Phytochem 197,113124 (2022).    
90 Eze PM, Simons V, Seidemann T, Wang L, Kiffe-Delf AL, Frank M, van Geelen L, Abba CC, Esimone CO, Okoye FBC, Kalscheuer R. Serratiochelins A and B from Serratia marcescens show xenosiderophoric characteristics towards Acinetobacter baumannii and Mycobacterium tuberculosis. Trop J Pharm Res 20, 2551-2658 (2021).    
89 Eze P, Gao Y, Liu Y, van Geelen L, Ejikeugwu C, Esimone C, Okoye F, Proksch P, Kalscheuer R. Secondary metabolites of a marine-derived Penicillium ochrochloron. Not Sci Biol 13, 11020 (2021).    
88 Harwoko H, Lee J, Daletos G, Feldbrügge M, Kalscheuer R, Proksch P. Antimicrobial compound from Trichoderma harzianum, an endophytic fungus associated with ginger (Zingiber officinale). Indonesian J Med Health (JKKI) 12, 151-157 (2021).    
87 Wang L, Ma QY, Kong FD, Xie QY, Zhou LM, Dai HF, Kalscheuer R, Wu YG, Zhao YX. Chemical constituents and nematocidal activity of the fruiting body of Ramaria stricta  Chem Nat Comp 57, 720-723 (2021).    
86 Schages L, Wichern F, Geisen S, Kalscheuer R, Bockmühl D. Distinct resistomes and microbial communities of soils, wastewater treatment plants and households suggest development of antibiotic resistances due to distinct environmental conditions in each environment. Antibiotics 10, 514 (2021).    
85 Ariantari N, Frank M, Gao Y, Stuhldreier F, Kiffe-Delf AL, Hartmann R, Höfert SP, Janiak C, Wesselborg S, Müller WEG, Kalscheuer R, Liu Z, Proksch. Fusaristatins D–F and (7S,8R)-(−)-chlamydospordiol from Fusarium sp. BZCB-CA, an endophyte of Bothriospermum chinense. Tetrahedron 85, 132065 (2021).    
84 Yu XQ, Gao Y, Frank M, Mandi A, Kurtan T, Müller WEG, Kalscheuer R, Guo ZY, Zou K, Liu Z, Proksch P. Induction of ambuic acid derivatives by the endophytic fungus Pestalotiopsis lespedezae through an OSMAC approach. Tetrahedron 79, 131876 (2021)    
83 Harwoko H, Daletos G, Stuhldreier F, Lee J, Wesselborg S, Feldbrügge M, Müller WEG, Kalscheuer R, Ancheeva E, Proksch P. Dithiodiketopiperazine derivatives from endophytic fungi Trichoderma harzianum and Epicoccum nigrum. Nat Prod Res 35, 257-265 (2021).    
82 Syson K, Batey SFD, Schindler S, Kalscheuer R, Bornemann S. A temperature-sensitive Mycobacterium smegmatis glgE mutation leads to a loss of GlgE enzyme activity and thermostability and the accumulation of α-maltose-1-phosphate. Biochim Biophys Acta Gen Subj 1865, 129783 (2021).    
81 Rehberg N, Sommer G, Drießen D, Kruppa M, Adeniyi ET, Chen S, Wang L, Wolf K, Tasch B, Ioerger TR, Zhu K, Müller TJJ, Kalscheuer R. Nature-inspired (di)azine-bridged bisindole alkaloids with potent antibacterial in vitro and in vivo efficacy against Methicillin-resistant Staphylococcus aureus. J Med Chem 63, 12623-12641 (2020).    
80 Schages L, Lucassen R, Wichern F, Kalscheuer R, Bockmühl D. The household resistome - frequency of β-lactamases, class 1 integron and antibiotic resistant bacteria in the domestic environment and their reduction during automated dishwashing/laundering. Appl Environ Microbiol 86, e02062-20 (2020).    
79 Reiners J, Lagedroste M, Gottstein J, Adeniyi ET, Kalscheuer R, Poschmann G, Stühler K, Smits SH, Schmitt L. Insights in the antimicrobial potential of the natural nisin variant nisin H. Front Microbiol 11, 573614 (2020).    
78 Hawerkamp HC, van Geelen L, Korte J, Di Domizio J, Swidergall M, Momin AA, Guzman Vega FJ, Arold ST, Ernst J, Gillie M, Kalscheuer R, Homey B, Meller S. Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis. Sci Rep 10, 17178 (2020).    
77 Harwoko H, Lee J, Hartmann R, Mándi A, Kurtán T, Müller WEG, Feldbrügge M, Kalscheuer R, Ancheeva E, Daletos G, Frank M, Liu Z, Proksch P. Azacoccones F-H, new flavipin-derived alkaloids from an endophytic fungus Epicoccum nigrum MK214079. Fitoterapia 146, 104698 (2020).    
76 Gao Y, Stuhldreier F, Schmitt L, Wesselborg S, Wang L, Müller WEG, Kalscheuer R, Guo Z, Zou K, Liu Z, Proksch P. Sesterterpenes and macrolide derivatives from the endophytic fungus Aplosporella javeedii. Fitoterapia 146, 104652 (2020).    
75 van Geelen L, Kaschani F, Sazzadeh SS, Adeniyi ET, Meier D, Proksch P, Pfeffer K, Kaiser M, Ioerger TR, Kalscheuer R. Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria. Appl Microbiol Biotechnol 104, 5985-5998 (2020).    
74 Gao Y, Wang L, Kalscheuer R, Liu Z, Proksch P. Antifungal polyketide derivatives from the endophytic fungus Aplosporella javeedii. Bioorg Med Chem 28, 115456 (2020).    
73 Moussa M, Ebrahim W, Kalscheuer R,  Liu Z, Proksch P. Co-culture of the bacterium Pseudomonas aeruginosa with the fungus Fusarium tricinctum induces bacterial antifungal and quorum sensing signaling molecules. Phytochem Lett 36, 37-41 (2020).    
72 Yu X, Müller W, Meier D, Kalscheuer R, Guo Z, Zou K, Umeokoli B, Liu Z, Proksch P. Polyketide derivatives from mangrove derived endophytic fungus Pseudopestalotiopsis theae. Mar Drugs 18, 129 (2020).    
71 Javid A, Cooper C, Singh A, Schindler S, Hänisch M, Marshall RL, Kalscheuer R, Bavro VN, Bhatt A. The mycolic acid reductase Rv2509 has distinct structural motifs and is essential for growth in slow-growing mycobacteria. Mol Microbiol 113, 521-533 (2020).    
70 Pan F, EI-Kashef D, Kalscheuer R, Müller WEG, Lee J, Feldbrügge M, Mándi A, Kurtán T, Liu Z, Wu W, Proksch P. Cladosins L-O, new hybrid polyketides from the endophytic fungus Cladosporium sphaerospermum WBS017. Eur J Med Chem 191, 112159 (2020).    
69 Ariantari N, Ancheeva E, Frank M, Stuhldreier F, Meier D, Gröner Y, Reimche I, Teusch N, Wesselborg S, Müller W, Kalscheuer R, Liu Z, Proksch P. Didymellanosine, a new decahydrofluorene analogue, and ascolactone C from Didymella sp. IEA-3B.1, an endophyte of Terminalia catappa. RSC Advances 10:7232–7240 (2020).    
68 Schages L, Wichern F, Kalscheuer R, Bockmühl D. Winter is coming – Impact of temperature on the variation of beta-lactamase and mcr genes in a wastewater treatment plant. Sci Total Environ 712:136499 (2020).    
67 Meier D, Vázquez Hernández M, van Geelen L, Muharini R, Proksch P, Bandow JE, Kalscheuer R. The plant-derived chalcone Xanthoangelol targets the membrane of Gram-positive bacteria. Bioorg Med Chem 27, 115151 (2019).    
66 Lienau C, Gräwert T, Alves Avelar LA, Illarionov B, Held J, Knaab TC, Lungerich B, van Geelen L, Meier D, Geissler S, Cynis H, Riederer U, Buchholz M, Kalscheuer R, Bacher A, Mordmüller B, Fischer M, Kurz T. Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity. Eur J Med Chem 181, 11555 (2019).    
65 Tran-Cong NM, Mándi A, Kurtán T, Müller WEG, Kalscheuer R, Lin W, Liu Z, Proksch P. Induction of cryptic metabolites of the endophytic fungus Trichocladium sp. through OSMAC and co-cultivation. RSC Advance 9, 27279–27288 (2019).    
64 Rehberg N, Omeje E, Ebada SS, van Geelen L, Liu Z, Sureechatchayan P, Kassack MU, Ioerger TR, Proksch P, Kalscheuer R. 3-O-Methyl-alkylgallates inhibit fatty acid desaturation in Mycobacterium tuberculosis. Antimicrob Agents Chemother 63, e00136-19 (2019).    
63 Steindor M, Nkwouano V, Stefanski A, Stuehler K, Ioerger TR, Bogumil D, Jacobsen M, Mackenzie CR, Kalscheuer R. A proteomics approach for the identification of species-specific immunogenic proteins in the Mycobacterium abscessus complex. Microbes Infect 21, 154-162 (2019).    
62 Kalscheuer R, Palacios A, Anso I, Cifuente J, Anguita J, Jacobs WR, Jr., Guerin ME, Prados-Rosales R. The Mycobacterium tuberculosis capsule: a cell structure with key implications in pathogenesis. Biochem J 476, 1995-2016 (2019).    
61 Zaschke-Kriesche J, Behrmann LV, Reiners J, Lagedroste M, Gröner Y, Kalscheuer R, Smits SHJ. Bypassing lantibiotic resistance by an effective nisin derivative. Bioorg Med Chem 27, 3454-3462 (2019).    
60 Moussa M, Weaam E, Bonus M, Gohlke H, Mándi A, Kurtán T, Hartmann R, Kalscheuer R, Lin W, Liu Z, Proksch P. Co-culture of the fungus Fusarium tricinctum with Streptomyces lividans induces production of cryptic naphthoquinone dimers. RSC Advances 9, 1491-1500 (2019).    
59 Abdel-Wahab NM, Scharf S, Özkaya FC, Kurtan T, Mandi A, Fouad MA, Kamel MS, Müller WEG, Kalscheuer R, Lin WH, Daletos G, Ebrahim W, Liu Z, Proksch P. Induction of Secondary Metabolites from the Marine-Derived Fungus Aspergillus versicolor through Co-cultivation with Bacillus subtilis. Planta Med 85, 503-512 (2019).    
58 Umeokoli BO, Ebrahim W, El-Neketi M, Muller WEG, Kalscheuer R, Lin W, Liu Z, Proksch P. A new depsidone derivative from mangrove sediment derived fungus Lasiodiplodia theobromae. Nat Prod Res 33, 2215-2222 (2019).    
57 Özkaya FC, Ebrahim W,  El-Neketi M,  Tansel Tanrikul T,  Kalscheuer R,  Müller WEG, Guo Z, Zou K, Liu Z, Proksch P. Induction of new metabolites from sponge-associated fungus Aspergillus carneus by OSMAC approach. Fitoterapia 131, 9–14. doi: 10.1016/j.fitote.2018.10.008 (2018).    
56 Abdelwahab MF, Fouad MA, Kamel MS, Özkaya FC, Kalscheuer R, Müller WEG, Lin W, Liu Z, Ebrahim W, Daletos G, Proksch P. Tanzawaic acid derivatives from freshwater sediment-derived fungus Penicillium sp. Fitoterapia 128, 258-264. doi: 10.1016/j.fitote.2018.05.019 (2018).    
55 Kamdem RST, Pascal W, Rehberg N, van Geelen L, Höfert SP, Knedel TO, Janiak C, Sureechatchaiyan P, Kassack MU, Lin W, Kalscheuer R, Liu Z, Proksch P. Metabolites from the endophytic fungus Cylindrocarpon sp. isolated from tropical plant Sapium ellipticum. Fitoterapia 128, 175-179. doi: 10.1016/j.fitote.2018.05.020 (2018).    
54 Kamariza M, Shieh P, Ealand CS, Peters JS, Chu B, Rodriguez-Rivera FP, Babu Sait MR, Treuren WV, Martinson N, Kalscheuer R, Kana BD, Bertozzi CR. Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe. Sci Translat Med 10, eaam6310  (2018).    
53 van Geelen L, Meier D, Rehberg N, Kalscheuer R. (Some) current concepts in antibacterial drug discovery. Appl Microbiol Biotechnol 102, 2949-2963 (2018).    
52 Rehberg N, Akone HS, Ioerger TR, Erlenkamp G, Daletos G, Gohlke H, Proksch P, Kalscheuer R. Chlorflavonin targets acetohydroxyacid synthase catalytic subunit IlvB1 for synergistic killing of Mycobacterium tuberculosis. ACS Infect Dis. 2018 Feb 9;4(2):123-134. doi: 10.1021/acsinfecdis.7b00055. Epub 2017 Nov 16.    
51 Ebada SS, El-Neketi M, Ebrahim W, Mándi A, Kurtán T, Kalscheuer R, Müller WEG, Proksch P. Cytotoxic secondary metabolites from the endophytic fungus Aspergillus versicolor KU258497. Phytochem Lett 24, 88-93. 10.1016/j.phytol.2018.01.010 (2018).    
50 Marmouzi I, Faouzi, ME, Saidi N, Cherrah Y, Rehberg N, Ebada SS, Ebrahim W, Kalscheuer R, Proksch P. Bioactive secondary metabolites from Chaetomium globosum, an endophyte from the Moroccan plant Avena sativa. ‎Chem Nat Compd 53, 1208-1211. doi: 10.1007/s10600-017-2242-6 (2017).    
49 Mokhlesi A, Stuhldreier F, Wex KW, Berscheid A, Hartmann R, Rehberg N, Sureechatchaiyan P, Chaidir C, Kassack MU, Kalscheuer R, Brötz-Oesterhelt H, Wesselborg S, Stork B, Daletos G, Proksch P. Cyclic cystine-bridged peptides from the marine sponge Clathria basilana induce apoptosis in tumor cells and depolarize the bacterial cytoplasmic membrane. J Nat Prod 80, 2941-2952. doi: 10.1021/acs.jnatprod.7b00477 (2017).    
48 Umeokoli BO, Onyegbule FA, Okoye FBC, Wang H, Kalscheuer R, Müller WEG, Hartmann R, Liu Z, Proksch P. New amide and dioxopiperazine derivatives from leaves of Breynia nivosa. Fitoterapia 122, 16-19. doi: 10.1016/j.fitote.2017.08.009 (2017).    
47 Ebada SS, de Voogd N, Kalscheuer R, Mueller WEG, Chaidir, Proksch P. Cytotoxic drimane meroterpenoids from the Indonesian marine sponge Dactylospongia elegans. Phytochem Lett 22, 154-158. doi: 10.1016/j.phytol.2017.09.026 (2017).    
46 Elnaggar MS, Ebrahim W, Mándi A, Kurtán T, Müller WEG, Kalscheuer R, Singab A, Lin W, Liu Z, Proksch P. Hydroquinone derivatives from the marine-derived fungus Gliomastix sp.. RSC Adv 7, 30640-30649. doi: 10.1039/C7RA04941B (2017).    
45 Ancheeva E, Küppers L, Akone SH, Ebrahim W, Liu Z, Mándi A, Kurtán T, Lin W, Orfali R, Rehberg N, Kalscheuer R, Daletos G, Proksch P. Expanding the metabolic profile of the fungus Chaetomium sp. through co-culture with autoclaved Pseudomonas aeruginosa. Eur J Org Chem 2017, 3256–3264. doi:10.1002/ejoc.201700288 (2017).    
44 Elshaarawy RFM, Mustafa FHA, van Geelen L, Abou-Taleb AEA, Tadros HRZ, Kalscheuer R, Janiak C. Mining marine shell wastes for polyelectrolyte chitosan anti-biofoulants: Fabrication of high-performance economic and ecofriendly anti-biofouling coatings. Carbohydr Polym 172, 352-364. doi: 10.1016/j.carbpol.2017.05.059 (2017).    
43 Prados-Rosales R, Carreño L, Cheng T, Blanc C, Weinrick B, Malek A, Lowary TL, Baena A, Joe M, Bai Y, Kalscheuer R, Batista-Gonzalez A, Saavedra NA, Sampedro L, Tomás J, Anguita J, Hung SC, Tripathi A, Xu J, Glatman-Freedman A, Jacobs WR Jr, Chan J, Porcelli SA, Achkar JM, Casadevall A. Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine. PLoS Pathog. 13, e1006250. doi: 10.1371/journal.ppat.1006250 (2017).    
42 Nkwouano V, Witkowski S, Rehberg N, Kalscheuer R, Nausch N, Mayatepek E, Jacobsen M. A novel mycobacterial in vitro infection assay identifies differences of induced macrophage apoptosis between CD4+ and CD8+ T cells. PLoS One 12, e0171817. doi: 10.1371/journal.pone.0171817 (2017).    
41 Muharini R, Díaz A, Ebrahim W, Mándi A, Kurtán T, Rehberg N, Kalscheuer R, Hartmann R, Orfali RS, Lin W, Liu Z, Proksch P. Antibacterial and cytotoxic phenolic metabolites from the fruits of Amorpha fruticosa. J Nat Prod 80, 169-180. doi: 10.1021/acs.jnatprod.6b00809 (2017).    
40 Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR Jr, Bornemann S, Ioerger TR, Ehrt S, Kalscheuer R. Trehalose-6-phosphate-mediated toxicity determines essentiality of OtsB2 in Mycobacterium tuberculosis in vitro and in mice. PLoS Pathog. 12:e1006043. doi: 10.1371/journal.ppat.1006043 (2016).    
39 Liu S, Dai H, Konuklugil B, Orfali RS, Lin W, Kalscheuer R, Liu Z , Proksch P. Phenolic bisabolanes from the sponge-derived fungus Aspergillus sp.. Phytochem Lett 18, 187–191. doi: 10.1016/j.phytol.2016.10.015 (2016).    
38 Daletos G, Ancheeva E, Chaidir C, Kalscheuer R, Proksch P. Antimycobacterial metabolites from marine invertebrates. Arch Pharm (Weinheim) 349:763-773. doi: 10.1002/ardp.201600128. Review. (2016).    
37 Koliwer-Brandl H, Syson K, van de Weerd R, Chandra G, Appelmelk B, Alber M, Ioerger TR, Jacobs Jr. WR,  Geurtsen J, Bornemann S, Kalscheuer R. Metabolic network for the biosynthesis of intra- and extracellular α-glucans required for virulence of Mycobacterium tuberculosis. PLoS Pathog 12, e1005768. doi:10.1371/journal.ppat.1005768 (2016).    
36 Steiger J, Stephan A, Inkeles MS, Realegeno S, Bruns H, Kröll P, de Castro Kroner J, Sommer A, Batinica M, Pitzler L, Kalscheuer R, Hartmann P, Plum G, Stenger S, Pellegrini M, Brachvogel B, Modlin RL, Fabri M. Imatinib triggers phagolysosome acidification and antimicrobial activity against Mycobacterium bovis Bacille Calmette-Guérin in glucocorticoid-treated human macrophages. J Immunol 197, 222-232. doi: 10.4049/jimmunol.1502407 (2016).    
35 Rashid AM, Batey SF, Syson K, Koliwer-Brandl H, Miah F, Barclay JE, Findlay KC, Nartowski KP, Khimyak YZ, Kalscheuer R, Bornemann S. The assembly of α-glucan by GlgE and GlgB in mycobacteria and streptomycetes. Biochemistry 55, 3270-3284. doi: 10.1021/acs.biochem.6b00209 (2016).    
34 Ebrahim W, El-Neketi M, Lewald LI, Orfali RS, Lin W, Rehberg N, Kalscheuer R, Daletos G, Proksch P. Metabolites from the fungal endophyte Aspergillus austroafricanus in axenic culture and in fungal-bacterial mixed cultures. J Nat Prod 79, 914-922 (2016).    
33 Famulla K, Sass P, Malik I, Akopian T, Kandror O, Alber M, Hinzen B, Ruebsamen-Schaeff H, Kalscheuer R, Goldberg AL, Brotz-Oesterhelt H. Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease. Mol Microbiol 101, 194-209. doi: 10.1111/mmi.13362 (2016).    
32 Ates LS, Ummels R, Commandeur S, van de Weerd R, Sparrius M, Weerdenburg E, Alber M, Kalscheuer R, Piersma SR, Abdallah AM, Abd El Ghany M, Abdel-Haleem AM, Pain A, Jimenez CR, Bitter W, Houben EN. Essential role of the ESX-5 secretion system in outer membrane permeability of pathogenic mycobacteria. PLoS Genet 11, e1005190 (2015).    
31 Daletos G, Kalscheuer R, Koliwer-Brandl H, Hartmann R, de Voogd NJ, Wray V, Lin W, Proksch P. Callyaerins from the marine sponge Callyspongia aerizusa: Cyclic peptides with antitubercular activity. J Nat Prod 78, 1910-1925 (2015).    
30 Kalscheuer R, Koliwer-Brandl H. Genetics of mycobacterial trehalose metabolism. Microbiol Spectr 2 (2014).    
29 Urbanek BL, Wing DC, Haislop KS, Hamel CJ, Kalscheuer R, Woodruff PJ, Swarts BM. Chemoenzymatic synthesis of trehalose analogues: rapid access to chemical probes for investigating mycobacteria. Chembiochem 15, 2066-2070 (2014).    
28 Miah F, Koliwer-Brandl H, Rejzek M, Field RA, Kalscheuer R, Bornemann S. Flux through trehalose synthase flows from trehalose to the alpha anomer of maltose in mycobacteria. Chem Biol 20, 487-493 (2013).    


Leiba J, Syson K, Baronian G, Zanella-Cleon I, Kalscheuer R, Kremer L, Bornemann S, Molle V. Mycobacterium tuberculosis maltosyltransferase GlgE, a genetically validated antituberculosis target, is negatively regulated by Ser/Thr phosphorylation. J Biol Chem 288, 16546-16556 (2013).    
26 Swarts BM, Holsclaw CM, Jewett JC, Alber M, Fox DM, Siegrist MS, Leary JA, Kalscheuer R, Bertozzi CR. Probing the mycobacterial trehalome with bioorthogonal chemistry. J Am Chem Soc 134, 16123-16126 (2012).    
25 Prados-Rosales R, Baena A, Martinez LR, Luque-Garcia J, Kalscheuer R, Veeraraghavan U, Camara C, Nosanchuk JD, Besra GS, Chen B, Jimenez J, Glatman-Freedman A, Jacobs WR, Jr., Porcelli SA, Casadevall A. Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice. J Clin Invest 121, 1471-1483 (2011).    
24 Kalscheuer R, Syson K, Veeraraghavan U, Weinrick B, Biermann KE, Liu Z, Sacchettini JC, Besra G, Bornemann S, Jacobs WR, Jr. Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway. Nat Chem Biol 6, 376-384 (2010).    
23 Kalscheuer R, Jacobs WR, Jr. The significance of GlgE as a new target for tuberculosis. Drug News Perspect 23, 619-624 (2010).    
22 Manilla-Perez E, Reers C, Baumgart M, Hetzler S, Reichelt R, Malkus U, Kalscheuer R, Waltermann M, Steinbuchel A. Analysis of lipid export in hydrocarbonoclastic bacteria of the genus Alcanivorax: identification of lipid export-negative mutants of Alcanivorax borkumensis SK2 and Alcanivorax jadensis T9. J Bacteriol 192, 643-656 (2010).    
21 Manilla-Perez E, Lange AB, Hetzler S, Waltermann M, Kalscheuer R, Steinbuchel A. Isolation and characterization of a mutant of the marine bacterium Alcanivorax borkumensis SK2 defective in lipid biosynthesis. Appl Environ Microbiol 76, 2884-2894 (2010).    
20 Kalscheuer R, Weinrick B, Veeraraghavan U, Besra GS, Jacobs WR, Jr. Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 107, 21761-21766 (2010).    
19 Kaddor C, Biermann K, Kalscheuer R, Steinbuchel A. Analysis of neutral lipid biosynthesis in Streptomyces avermitilis MA-4680 and characterization of an acyltransferase involved herein. Appl Microbiol Biotechnol 84, 143-155 (2009).    
18 Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR, Jr., Strynadka N, Eltis LD. Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis. PLoS Pathog 5, e1000344 (2009).    
17 Capyk JK, Kalscheuer R, Stewart GR, Liu J, Kwon H, Zhao R, Okamoto S, Jacobs WR, Jr., Eltis LD, Mohn WW. Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids. J Biol Chem 284, 35534-35542 (2009).    
16 Alvarez AF, Alvarez HM, Kalscheuer R, Waltermann M, Steinbuchel A. Cloning and characterization of a gene involved in triacylglycerol biosynthesis and identification of additional homologous genes in the oleaginous bacterium Rhodococcus opacus PD630. Microbiology 154, 2327-2335 (2008).    
15 Kalscheuer R, Stoveken T, Malkus U, Reichelt R, Golyshin PN, Sabirova JS, Ferrer M, Timmis KN, Steinbuchel A. Analysis of storage lipid accumulation in Alcanivorax borkumensis: Evidence for alternative triacylglycerol biosynthesis routes in bacteria. J Bacteriol 189, 918-928 (2007).    
14 Sabirova JS, Ferrer M, Lunsdorf H, Wray V, Kalscheuer R, Steinbuchel A, Timmis KN, Golyshin PN. Mutation in a "tesB-like" hydroxyacyl-coenzyme A-specific thioesterase gene causes hyperproduction of extracellular polyhydroxyalkanoates by Alcanivorax borkumensis SK2. J Bacteriol 188, 8452-8459 (2006).    
13 Kalscheuer R, Stoveken T, Luftmann H, Malkus U, Reichelt R, Steinbuchel A. Neutral lipid biosynthesis in engineered Escherichia coli: jojoba oil-like wax esters and fatty acid butyl esters. Appl Environ Microbiol 72, 1373-1379 (2006).    
12 Kalscheuer R, Stolting T, Steinbuchel A. Microdiesel: Escherichia coli engineered for fuel production. Microbiology 152, 2529-2536 (2006).    
11 Waltermann M, Hinz A, Robenek H, Troyer D, Reichelt R, Malkus U, Galla HJ, Kalscheuer R, Stoveken T, von Landenberg P, Steinbuchel A. Mechanism of lipid-body formation in prokaryotes: how bacteria fatten up. Mol Microbiol 55, 750-763 (2005).    
10 Uthoff S, Stoveken T, Weber N, Vosmann K, Klein E, Kalscheuer R, Steinbuchel A. Thio wax ester biosynthesis utilizing the unspecific bifunctional wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase of Acinetobacter sp. strain ADP1. Appl Environ Microbiol 71, 790-796 (2005).    
9 Stoveken T, Kalscheuer R, Malkus U, Reichelt R, Steinbuchel A. The wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase from Acinetobacter sp. strain ADP1: characterization of a novel type of acyltransferase. J Bacteriol 187, 1369-1376 (2005).    
8 Kalscheuer R, Luftmann H, Steinbuchel A. Synthesis of novel lipids in Saccharomyces cerevisiae by heterologous expression of an unspecific bacterial acyltransferase. Appl Environ Microbiol 70, 7119-7125 (2004).    
7 Kalscheuer R, Steinbuchel A. A novel bifunctional wax ester synthase/acyl-CoA:diacylglycerol acyltransferase mediates wax ester and triacylglycerol biosynthesis in Acinetobacter calcoaceticus ADP1. J Biol Chem 278, 8075-8082 (2003).    
6 Arenskotter M, Baumeister D, Kalscheuer R, Steinbuchel A. Identification and application of plasmids suitable for transfer of foreign DNA to members of the genus Gordonia. Appl Environ Microbiol 69, 4971-4974 (2003).    
5 Kalscheuer R, Waltermann M, Alvarez M, Steinbuchel A. Preparative isolation of lipid inclusions from Rhodococcus opacus and Rhodococcus ruber and identification of granule-associated proteins. Arch Microbiol 177, 20-28 (2001).    
4 Alvarez HM, Kalscheuer R, Steinbuchel A. Accumulation and mobilization of storage lipids by Rhodococcus opacus PD630 and Rhodococcus ruber NCIMB 40126. Appl Microbiol Biotechnol 54, 218-223 (2000).    
3 Waltermann M, Luftmann H, Baumeister D, Kalscheuer R, Steinbuchel A. Rhodococcus opacus strain PD630 as a new source of high-value single-cell oil? Isolation and characterization of triacylglycerols and other storage lipids. Microbiology 146 ( Pt 5), 1143-1149 (2000).    
2 Spiekermann P, Rehm BH, Kalscheuer R, Baumeister D, Steinbuchel A. A sensitive, viable-colony staining method using Nile red for direct screening of bacteria that accumulate polyhydroxyalkanoic acids and other lipid storage compounds. Arch Microbiol 171, 73-80 (1999).    
1 Kalscheuer R, Arenskotter M, Steinbuchel A. Establishment of a gene transfer system for Rhodococcus opacus PD630 based on electroporation and its application for recombinant biosynthesis of poly(3-hydroxyalkanoic acids). Appl Microbiol Biotechnol 52, 508-515 (1999).