2008

Originalarbeiten

Y. Thielmann, J. Mohrlüder, B. W. Koenig, T. Stangler, R. Hartmann, K. Becker, H.-D. Höltje and D. Willbold
An Indole-Binding Site is a Major Determinant of the Ligand Specificity of the GABA Type A Receptor-Associated Protein GABARAP
ChemBioChem 9, 1967-1775 (2008)

H.-D. Höltje
Drug Design: Was theoretische Verfahren in der Arzneistoffentwicklung leisten.
Pharm.Ztg. 153, 4692-4701 (2008)

A. Richartz, M. Höltje, B. Brandt, M. Schäfer-Korting und H.-D. Höltje
Targeting human DNA polymerase α for the inhibition of keratinocyte proliferation.
Part 1. Homology model, active site architecture and ligand binding
Journal of Enzyme Inhibition and Medicinal Chemistry 23, 94-100 (2008)

T.Kaimann, S.Metzger, K.Kuhlmann, B.Brandt, H.-D. Höltje and D.Riesner
Molecular model of an a-helical prion-prion dimer and its monomeric subunits as derived from chemical cross-linking and molecular modelling.
J.Biol.Chem. 376, 582-596 (2008)

J.Antony, K.Kellersohn, M.Mohr-Andrä, S.Prilla, C.Tränkle, K.Mohr, T.Disignini, C.Dallanoce, M.de Amici, M.Muth, U.Holzgrabe, S.Bertoni, E.Barocelli, H.-D.Höltje, J.Schrobang and A.Christopoulos
Dualsteric GPCR targeting: A novel route to binding and signaling pathway selectivity.
FASEB J. 23, 442-450 (2008)

Thomas Hohlfeld, Norbert Zimmermann, Artur-Aron Weber, Gisela Jessen, Horst Weber, Karsten Schrör, Hans-Dieter Höltje, Rainer Ebel
Pyrazole analgesics prevent the antiaggregatory effect of aspirin and preserve platelet thromboxane synthesis
J.Thromb.Haemost. 6, 166-173 (2008)