Focus Group "Granulation / Compaction"

Leader:

Members:

  • Jerome Hansen
  • Hannah Lou Keizer
  • Sebastian Pohl
  • Annika Wilms

Recent topics:

  • Development of oral dispersible tablets and minitablets (ODT, ODMT) and their characterisation
  • Functionality of disintegrants
  • Roll compaction / dry granulation
  • Melt granulation in high shear mixer
  • Comilling

Publications:

A. Wilms, K. Knop, P. Kleinebudde
Combination of a rotating tube sample divider and dynamic image analysis for continuous on-line determination of granule size distribution
Int. J. Pharm. X 1 (2019) 1000029.

J. Peters, W. Taute, C. Döscher, M. Höft, R. Knöchel, J. Breitkreutz
Moisture monitoring in fluid-bed granulation by multi-resonance microwave sensor: Applicability on crystal-water containing Donepezil granules
AAPS Pharm Sci. Tech. 20(1): 6 (2019).

J. Peters, W. Taute, C. Döscher, R. Meier, M. Höft, R. Knöchel, J. Breitkreutz
From laboratory- to pilot-scale: moisture monitoring in fluidized bed granulation by a novel microwave sensor using multivariate calibration approaches
Drug Dev. Ind. Pharm. 44: 961-968 (2018).

A. Lazzari, P. Kleinebudde & K. Knop
Xanthan gum as a rate-controlling polymer for the development of alcohol resistant matrix tablets and mini-tablets.
Int. J. Pharm. 536 (2018) 440-449.

J. Harting & P. Kleinebudde
Development of an in-line Raman spectroscopic method for continuous API quantification during twin-screw wet granulation.
Eur. J. Pharm. Biopharm. 125 (2018) 169-181.

S. Grote & P. Kleinebudde
Roll compaction/ dry granulation of dibasic calcium phosphate anhydrous – Does the morphology of the raw material influence the tabletability of dry granules?
J. Pharm. Sci. 107 (2018) 1104-1111.

H. Mangal & P. Kleinebudde
Is the adjustment of the impeller speed a reliable attempt to influence granule size in continuous dry granulation?
Adv. Powder Technol. 29 (2018) 1339-1347.

S. Grote & P. Kleinebudde
Impact of functionalised particle structure on roll compaction/ dry granulation and tableting of calcium carbonate.
Int. J. Pharm. 544 (2018) 235-241.

K. Csordás, R. Wiedey & P. Kleinebudde
Impact of roll compaction design, process parameters and material deformation behaviour on ribbon relative density.
Drug Dev. Ind. Pharm. 44 (2018) 1295-1306.

R. Wiedey, R. Šibanc & P. Kleinebudde
Laser based thermo-conductometry as an approach to determine ribbon solid fraction off-line and in-line.
Int. J. Pharm. 547 (2018) 330-337.

Y. Thabet, J. Walsh, J. Breitkreutz
Flexible and precise dosing of enalapril maleate for all paediatric age groups utilizing orodispersible minitablets
Int. J. Pharm. 541: 136-142 (2018).

J. Peters, A. Teske, W. Taute, C. Döscher, M. Höft, R. Knöchel, J. Breitkreutz
Real-time process monitoring in a semi-continuous fluid-bed dryer – microwave resonance technology versus near-infrared spectroscopy
Int. J. Pharm. 537: 193-201 (2018).

G.F. Petrovick, P. Kleinebudde, J. Breitkreutz
Orodispersible tablets containing taste-masked solid lipid pellets with metformin hydrochloride: Influence of process parameters on tablet properties
Eur. J. Pharm. Biopharm. 122: 137-145 (2018).

M. Münster, C. Schoch, C. Schmidt, J. Breitkreutz
Multiparticulate system combining taste masking and immediate release properties for the aversive compound praziquantel
Eur. J. Pharm. Sci. 109: 446-454 (2017).

A. Perez Gago & P. Kleinebudde
MCC-mannitol mixtures after roll compaction/dry granulation: Percolation thresholds for ribbon microhardness and granule size distribution.
Pharm. Dev. Technol. 22 (2017) 764-774.

R. Wiedey & P. Kleinebudde
The density distribution in ribbons from roll compaction.
Chem. Ing. Tech. 89 (2017) 1017-1024.

R. Meier, K.-P. Moll, M. Krumme & P. Kleinebudde
Simplified, high drug-loaded formulations containing hydrochlorothiazide for twin-screw granulation.
Chem. Ing. Tech. 89 (2017) 1025-1033.

R. Meier, K.-P. Moll, M. Krumme & P. Kleinebudde
How deformation behaviour controls product performance after twin-screw granulation.
J. Pharm. Sci. 106 (2017) 291-301.

P. Kazemi, M.H. Khalid, A. Perez Gago, P. Kleinebudde, R. Jachowicz, J. Szlęk, A. Mendyk
Effect of roll compaction on granule size distribution of MCC-mannitol mixtures: computational intelligence modeling and parametric analysis.
Drug Des. Dev. Ther. 11 (2017) 241-251.

R. Meier, K.-P. Moll, M. Krumme & P. Kleinebudde
Impact of fill-level in twin-screw granulation on critical quality attributes of granules and tablets.
Eur. J. Pharm. Biopharm. 115 (2017) 102-112.

H. Mangal & P. Kleinebudde
Experimental determination of residence time distribution in continuous dry granulation.
Int. J. Pharm. 524 (2017) 91-100.

H. Mangal, M. Kirsolak & P. Kleinebudde
Roll compaction/ dry granulation: Suitability of different binders
Int. J. Pharm. 503 (2016) 213-219.

L. Perez-Gandarillas, A. Perez-Gago, A. Mazor, P. Kleinebudde, O. Lecoq & A. Michrafy
Effect of roll-compaction and milling conditions on granules and tablet properties.
Eur. J. Pharm. Biopharm. 106 (2016) 38-49.

R. Meier, M. Thommes, N. Rasenack, K.-P. Moll, M. Krumme & P. Kleinebudde
Granule size distributions after twin-screw granulation - Do not forget the feeding systems.
Eur. J. Pharm. Biopharm. 106 (2016) 59-69.

J. Quodbach & P. Kleinebudde
A critical review on tablet disintegration.
Pharm. Dev. Technol. 21 (2016) 763-774.

C.C. Sun & P. Kleinebudde
Mini review: Mechanisms to the loss of tabletability by dry granulation.
Eur. J. Pharm. Biopharm. 106 (2016) 9-14.

J. Quodbach, A. Moussavi, R. Tammer, J. Frahm & P. Kleinebudde
Tablet disintegration studied by high-resolution real-time magnetic resonance imaging.
J. Pharm. Sci. 103 (2014) 249-255.

J. Mosig & P. Kleinebudde
Evaluation of lubrication methods: How to generate a comparable lubrication for dry granules and powder material for tableting processes.
Powder Technol. 266 (2014) 156-166.

A. Fussell, C.J. Strachan, P. Kleinebudde & H. Offerhaus
Coherent anti-Stokes Raman scattering (CARS) microscopy visualizes pharmaceutical tablets during dissolution.
J. Vis. Exp. Issue 89 (2014) URL: www.jove.com/video/51847 DOI: doi:10.3791/51847

J. Quodbach, A. Moussavi, R. Tammer, J. Frahm & P. Kleinebudde
Assessment of disintegrant efficacy with fractal dimensions from real-time MRI.
Int J. Pharm. 475 (2014) 605-612.

J. Sakwanichol, S. Puttipipatkhachorn, G. Ingenerf & P. Kleinebudde
Roll compaction/ dry granulation: Possibility to use roll mill in dry granulation step.
Pharm. Dev. Technol. 17 (2012) 30-39.

Tißen C., Wörtz K., Breitkreutz J., Kleinebudde P.
Development of mini-tablets with 1 mm and 2 mm diameter.
Int. J. Pharm. 416, 164-170 (2011)

Stoltenberg I., Breitkreutz J.
Orally disintegrating mini-tablets (ODMTs) - A novel solid dosage form for paediatric use
Eur. J. Pharm. Biopharm. 78, 462-469 (2011)

Ghanam D., Kleinebudde P.
Suitability of kappa-carrageenan pellets for the formulation of multiparticulate tablets with modified release.
Int. J. Pharm. 409, 9-18 (2011)

Kuntz T., Schubert M.A., Kleinebudde P.
Increased compactability of acetames after roll compaction.
Eur. J. Pharm. Biopharm. 77, 164-169 (2011)

Djuric D., Kleinebudde P.
Continuous granulation with a twin-screw extruder: Impact of material throughput.
Pharm. Dev. Technol. 15, 518-525 (2010)

Kristó K., Bajdik J., Kleinebudde P., Pintye-Hódi K.
Effect of lubricant on spreading of coating liquid on surface of tablets containing pancreatin.
Pharm. Dev. Technol. 15, 354-359 (2010)

Ghanam D., Hassan I., Kleinebudde P.
Compression behaviour of kappa-carrageenan pellets.
Int. J. Pharm. 390, 117-127 (2010)

Pauli-Bruns A., Knop K., Lippold B.C.
Preparation of sustained release matrix pellets by melt agglomeration in the fluidized bed: Influence of formulation variables and modelling of agglomerate growth
Eur. J. Pharm. Biopharm. 74, 503-512 (2010)

Conference contributions:

Hermes M, Breitkreutz J
Orodispersible minitablets as a child-appropriate dosage form with enalapril maleate: Avoiding the problems of extemporaneous formulations? (oral)
3rd EuPFI conference, F-Strasbourg (2011)

Stoltenberg I., Breitkreutz J.
ODMTs with taste-masked zinc sulphate as a child-appropriate dosage form for developing countries (Poster)
3rd EuPFI meeting, F-Strasbourg (2011)

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Verantwortlich für den Inhalt: E-Mail sendenDr. R. Wiedey