Focus Group "Advanced Analytics"

Leader:

Members:

  • Bastian Hahn
  • Martin Müller
  • Jhinuk Rahman
  • Annika Wilms

Recent topics:

  • Sensors and actuators for pharmaceutical use
  • Taste sensing systems (electronic tongues)
  • Process analytical technologies: MRS, NIR, Raman
  • Upper airways modelling

Publications: 

J. Peters, W. Taute, C. Döscher, M. Höft, R. Knöchel, J. Breitkreutz
Moisture monitoring in fluid-bed granulation by multi-resonance microwave sensor: Applicability on crystal-water containing Donepezil granules
AAPS Pharm Sci. Tech. 20(1): 6 (2019)

J. Peters, W. Taute, C. Döscher, R. Meier, M. Höft, R. Knöchel, J. Breitkreutz
From laboratory- to pilot-scale: moisture monitoring in fluidized bed granulation by a novel microwave sensor using multivariate calibration approaches
Drug Dev. Ind. Pharm. 44: 961-968 (2018)

J. Peters, A. Teske, W. Taute, C. Döscher, M. Höft, R. Knöchel, J. Breitkreutz
Real-time process monitoring in a semi-continuous fluid-bed dryer – microwave resonance technology versus near-infrared spectroscopy
Int. J. Pharm. 537: 193-201 (2018)

M. Münster, A.H.A. Mohamed-Ahmed, L.I. Immohr, C. Schoch, C. Schmidt, C. Tuleu, J. Breitkreutz
Comparative in vitro and in vivo taste assessment of liquid praziquantel formulations
Int. J. Pharm. 529: 310-318 (2017)

J. Peters, K. Bartscher, C. Döscher, W. Taute, M. Höft, R. Knöchel, J. Breitkreutz
In-line moisture monitoring in fluidized bed granulation using a novel multi-resonance microwave sensor
Talanta 170: 369-376 (2017)

J. Peters, W. Taute, K. Bartscher, C. Döscher, M. Höft, R. Knöchel, J. Breitkreutz
Design, development and method validation of a novel multi-resonance microwave sensor for moisture measurement
Anal. Chim. Acta 961: 119-127 (2017)

M. Khaydukova, D. Kirsanov, M. Pein-Hackelbusch, L.I. Immohr, V. Gilemkhanova, A. Legin
Critical view on drug dissolution in artificial saliva: a possible use of in-line tongue measurements
Eur. J. Pharm. Sci. 99: 266-271 (2017)

L.I. Immohr, C. Hedfeld, A. Lang, M. Pein
Suitability of e-tongue sensors to assess taste-masking of pediatric liquids by different beverages considering their physico-chemical properties
AAPS PharmSciTech 18: 330-340 (2017)

L.I. Immohr, R. Turner, M. Pein
Data for pre-performance test of self-developed electronic tongue sensors
Data in Brief 9: 1090-1093 (2016)

L.I. Immohr, R. Turner, M. Pein
Impact of sodium lauryl sulfate in oral liquids on e-tongue measurements
Int. J. Pharm. 515: 441-448 (2016)

M. Preis, L. Grother, P. Axe, J. Breitkreutz
In-vitro and in-vivo evaluation of taste-masked cetirizine hydrochloride formulated in oral lyophilisates
Int. J. Pharm. 491: 8-16 (2015)

M. Preis, D. Gronkowsky, D. Grytzan, J. Breitkreutz
Comparative study on novel test systems to determine disintegration time of orodispersible films
J. Pharm. Pharmacol. 66: 1102-1111 (2014)

M. Preis, O. Häusler, J. Breitkreutz
Electronic tongues in preformulation studies - Application of electronic tongues in preformulations studies to evaluate taste-masking capacities of maltodextrins
Pharm. Ind. 76: 957-962 (2014)

S. Lindert, A. Below, J. Breitkreutz
Performance of dry powder inhalers with single dosed capsules in preschool children and adults using improved upper airway models
Pharmaceutics 6: 36-51 (2014)

M. Preis, C. Eckert, O. Häusler, J. Breitkreutz
A comparative study on solubilizing and taste-masking capacities of hydroxypropyl-ß-cyclodextrin and maltodextrins with high amylose content
Sensors & Actuators B 193: 442-450 (2014)

R. Krampe, D. Sieber, M. Pein, J. Breitkreutz
A new biorelevant dissolution method for orodispersible films
Eur. J. Pharm. Biopharm. 98: 20-25 (2016)

M. Rohrschneider, S. Bhagwat, R. Krampe, V. Michler, J. Breitkreutz, G. Hochhaus
Evaluation of the Transwell® system for characterization of dissolution behavior of inhalation drugs: Effects of membrane and surfactant
Mol. Pharm. 12: 2618-24 (2015)

Pein, M., Kirsanov, D., Ciosek, P., del Valle, M., Yaroshenko, I., Wesoły, M., Zabadaj, M., Gonzalez-Calabuig, A., Wróblewski, W., Legin, A.;
Independent comparison study of six different electronic tongues applied for pharmaceutical analysis;
J. Pharm. Biomed. Anal., 2015, 114, 321-329.

Kiene, F.E., Pein, M., Thommes, M.;
Orientation to Determine Quality Attributes of Flavoring Excipients containing Volatile Molecules;
J. Pharm. Biomed. Anal., 2015, 110, 20-26.

Folttmann, F., Knop, K., Kleinebudde, P., Pein, M.;
In-line spatial filtering velocimetry for particle size and film thickness determination in fluidized-bed pellet coating processes;
Eur. J. Pharm. Biopharm., 2014, 88 (3), 931-938.

C. Eckert, M. Pein, J. Breitkreutz;
Lean production of taste improved lipidic sodium benzoate formulations
Eur. J. Pharm. Biopharm., 2014, 88 (2), 455-461.

Pein, M., Gondongwe, D. X., Habara, M., Winzenburg, G.
Interlaboratory testing of Insent e-tongues
Int. J. Pharm., 2014, 469 (2), 228-237 (http://dx.doi.org/10.1016/j.ijpharm.2014.02.036)

Pein, M., Preis, M., Eckert, C., Kiene, F. E.
Taste-masking assessment of solid oral dosage forms–A critical review
Int. J. Pharm., 2014; 465, 1-2, 239-254 (http://dx.doi.org/10.1016/j.ijpharm.2014.01.036)

Preis M., Knop K., Breitkreutz J.
Mechanical strength test for orodispersible and buccal films
Int. J. Pharm. 461 (2014) 22-29

Brock, D., Zeitler, J.A., Funke, A., Knop, K., Kleinebudde, P.
Evaluation of critical process parameters for intra-tablet coating uniformity using terahertz pulsed imaging
Eur. J. Pharm. Biopharm. 85 (2013) 1122-1129.

Brock, D., Zeitler, J.A., Funke, A., Knop, K., Kleinebudde, P.
Critical factors in the measurement of tablet film coatings using terahertz pulsed imaging
J. Pharm. Sci. 102 (2013) 1813-1824.

Wirges, M., Funke, A., Serno, P., Knop, K., Kleinebudde, P.
Development and in-line validation of a Process Analytical Technology to facilitate the scale up of coating processes
J. Pharm. Biomed. Analysis 78-79 (2013) 57-64.

Wirges, M., Funke, A., Serno, P., Knop, K., Kleinebudde, P.
Monitoring of an active coating process for two-layer tablets-model development strategies
J. Pharm. Sci. 102 (2013) 556-564.

Below A., Bickmann D., Breitkreutz J.
Assessing the performance of two dry powder inhalers in preschool children using an idealized upper airway model
Int. J. Pharm. 444 (2013) 169-174

Preis M., Woertz C., Kleinebudde P., Breitkreutz J.
Oromucosal film preparations: Classification and characterization methods
Expert Opinion on Drug Delivery 10 (2013)1303-1317

Woertz, C., Preis, M., Breitkreutz, J., Kleinebudde, P.
Assessment of test methods evaluating mucoadhesive polymers and dosage forms: An overview
Eur. J. Pharm. Biopharm. 85 (2013) 843-853.

Pein, M., Eckert, C., Preis, M., Breitkreutz, J.;
New protocol for αAstree electronic tongue enabling full performance qualification according to ICH Q2,
J. Pharm. Biomed. Anal., 2013, pp. 157-163

Eckert, C., Pein, M., Reimann, J., Breitkreutz, J.;
Taste evaluation of multicomponent mixtures using a human taste panel, electronic taste sensing systems and HPLC,
Sens. Actuat. B-Chem. 182, 2013, 294-299

Wirges, M., Pein M., Knop K., Kleinebudde P., Boeggering A., Funke A., Serno P.;
Raman vs. NIR - Echtzeit-Überwachung von Prozessen zum Wirkstoffüberzug auf Tabletten in der pharmazeutischen Industrie,
TechnoPharm 3, 2013, 98-107

J. Müller, D. Brock, K. Knop, J.A. Zeitler, P. Kleinebudde
Prediction of Dissolution Time and Coating Thickness of Sustained Release Formulations using Raman Spectroscopy and Terahertz Pulsed Imaging.
European Journal of Pharmaceutics and Biopharmaceutics 80 (2012) p.690-697; doi:10.1016/j.ejpb.2011.12.003
D. Brock, J.A. Zeitler, A. Funke, K. Knop, P. Kleinebudde
A Comparison of Quality Control Methods for Active Coating Processes.
International Journal of Pharmaceutics 439 (2012) p.289-295; doi: 10.1016/j.ijpharm.2012.09.021

I.S. Russe, D. Brock, K. Knop, P. Kleinebudde, J.A. Zeitler
Validation of Terahertz Coating Thickness Measurements using X-ray Microtomography.
Molecular Pharmaceutics 9 (2012) p.3551-3559; doi: 10.1021/mp300383y

N. Guffon, Y. Kibleur, W. Coppalu, C. Tissen, J. Breitkreutz
Studies of a new formulation of sodium phenylbutyrate.
Arch. Dis. Child. 97: 1081-1085 (2012)

M. Preis, M. Pein, J. Breitkreutz
Development of a taste-masked orodispersible film containing dimenhydrinate.
Pharmaceutics 4: 551-562 (2012)

M. Guhmann, M. Preis, F. Gerber, N. Pöllinger, J. Breitkreutz, W. Weitschies
Development of oral taste masked diclofenac formulations using a taste sensing system.
Int. J. Pharm. 438: 81-90 (2012)

J. Vaassen, K. Bartscher, J. Breitkreutz
Taste masked lipid pellets with enhanced release of hydrophobic active ingredient.
Int. J. Pharm. 429: 99-103 (2012)

Woertz K., Tissen C., Kleinebudde P., Breitkreutz J.
Development of a taste masked generic ibuprofen suspension - Top down approach guided by electronic tongue measurements.
J. Pharm. Sci. 100, 4460-4470 (2011)

Haaser M., Windbergs M., McGoverin C.M., Kleinebudde P., Rades T., Gordon K.C., Strachan C.J.
Analysis of matrix dosage forms during dissolution testing using Raman microscopy.
J. Pharm. Sci. 100, 4452-4459 (2011)

Woertz K., Tissen C., Kleinebudde P., Breitkreutz J.
Taste sensing systems (electronic tongues) for pharmaceutical applications.
Int. J. Pharm. 417, 256-271 (2011)

Eckert C., Lutz C., Breitkreutz J., Woertz K.
Quality control of oral herbal products by an electronic tongue - a case study on sage lozenges.
Sensors and Actuators B 156, 204-212 (2011)

Zhong S., Shen Y.-C., Ho L., May R., Zeitler J.A., Evans M., Taday P.T., Pepper M., Rades T., Gordon K.C., Müller R., Kleinebudde P.
Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography.
Opt. Laser Eng. 49, 361-365 (2011)

Woertz K., Tissen C., Kleinebudde P., Breitkreutz J.
A comparative study on two electronic tongues for pharmaceutical formulation development.
J. Pharm. Biomed. Anal. 55, 272-281 (2011)

Woertz K., Tissen C., Kleinebudde P., Breitkreutz J.
Rational development of taste masked oral liquids guided by an electronic tongue
Int. J. Pharm. 400, 114-123 (2010)

Windbergs M., Haaser M., McGoverin C., Gordon K., Kleinebudde P., Strachan C.J.
Investigating the relationship between drug distribution in solid lipid matrices and dissolution behaviour using raman spectroscopy and mapping.
J. Pharm. Sci. 99, 1464-1475 (2010)

Ho L., Müller R., Krüger C., Gordon K.C., Kleinebudde P., Pepper M., Rades T., Shen Y.C., Taday P.F., Zeitler J.A.
Investigating dissolution performance critical areas on coated tablets: A case study using terahertz pulsed imaging.J. Pharm. Sci. 99, 392-402 (2010)

Woertz K., Tissen C., Kleinebudde P., Breitkreutz J.
Performance qualification of an electronic tongue according to ICH guideline Q2.
J. Pharm. Biomed. Anal. 51, 497-506 (2010)

Conference contributions:

J. N. Jespensgaard, M. Pein
Interlab investigations on sensor performance using an electronic taste sensing system (poster)
AAPS Annual Meeting, Chicago 2012

D. Brock, J.A. Zeitler, A. Funke, K. Knop, P. Kleinebudde
The Use of Terahertz Pulsed Imaging to Assess Intra- and Inter-Tablet Coating Uniformity (poster)
AAPS Annual Meeting, Chicago 2012

C. Eckert, M. Pein
Improved taste evaluation of pharmaceutics using food sensors? (poster)
DPhG Jahrestagung, Greifswald 2012

E. Reitz, D. Brock, M. Thommes
Determination of Residence Time Distribution in Hot Melt Extrusion via Image Analysis (poster)
DPhG Jahrestagung, Greifswald 2012

E.J. Laukamp, M. Pein, M. Thommes, J. Breitkreutz
Carbamazepine modification in Mini-moulds: A question of analytical selectivity or formulation and production? (oral)
6th Annual PSSRC Symposium, Lissabon 2012

M. Pein, C. Eckert, M. Preis, J. Breitkreutz
Taste sensing system αAstree as analytical tool -Performance Qualification using caffeine citrate as model substance (oral)
APV Worldmeeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul 2012

D. Brock, J.A. Zeitler, A. Funke, K. Knop, P. Kleinebudde
Evaluating Critical Process Parameters in an Active Coating Process using Terahertz Pulsed Imaging and Design of Experiments (poster)
APV Worldmeeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul 2012

Brock D., Zeitler J.A., Funke A., Knop K., Kleinebudde P.
The use of Terahertz Pulsed Imaging to describe the evolution of an active coating process (poster)
6th Polish-German Symposium on Pharmaceutical Sciences, Düsseldorf 2011

Brock D., Zeitler J.A., Funke A., Knop K., Kleinebudde P.
Monitoring of an active coating process using Terahertz Pulsed Imaging (poster)
2nd European Conference on Process Analytics and Control Technology, Glasgow 2011

Below A., Bickmann D., Breitkreutz J.
In vitro performance of the Novolizer® (DPI) using mouth-throat models of 4-5-year-old children. (oral)
3rd EuPFI conference, Strasbourg (2011)

Preis M., Wörtz K., Breitkreutz J.
Taste assessment of orodispersible films containing dimenhydrinate by an electronic taste sensing system. (Poster)
3rd EuPFI meeting, F-Strasbourg (2011)

Below A., Bickmann D., Breitkreutz J.
Investigating the performance of a multidose dry powder inhaler using different upper airway models. (Poster)
ISAM 2011, NL-Rotterdam (2011)

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Verantwortlich für den Inhalt: E-Mail sendenDr. B. Fischer