2019      2018      2017     2016     2015     2014     2013     
2012      2011      2010     2009     2008     2007     2006     2005     2004    
2003      2002      2001     2000     vor 2000   Patente/Marken   




  • I. Speer, M. Preis, J. Breitkreutz

    Dissolution testing of oral film preparations: experimental comparison of compendial and non-compendial methods

    Int. J. Pharm. 561: 124-134 (2019)

  • I. Speer, M. Preis, J. Breitkreutz

    Novel dissolution method for oral film preparations with modified release properties

    AAPS Pharm Sci. Tech. 20(1): 7 (2019)

  • J. Peters, W. Taute, C. Döscher, M. Höft, R. Knöchel, J. Breitkreutz

    Moisture monitoring in fluid-bed granulation by multi-resonance microwave sensor: Applicability on crystal-water containing Donepezil granules

    AAPS Pharm Sci. Tech. 20(1): 6 (2019)

  • J. Quodbach, I. El Aita, J. Breitkreutz

    On-demand manufacturing of immediate release levetiracetam tablets using pressure-assisted microsyringe printing

    Eur. J. Pharm. Biopharm. 134: 29-36 (2019)

  • I. Speer, V. Lenhart, M. Preis, J. Breitkreutz

    Prolonged drug release from orodispersible films by incorporation of diclofenac-loaded micropellets

    Int. J. Pharm. 554: 149-160 (2019)






  • Y. Thabet, V. Klingmann, J. Breitkreutz

    Drug formulations: Standards and novel strategies for drug administration in pediatrics

    J. Clin. Pharmacol. 58: S26-S35 (2018)

  • V. Klingmann, H. Linderskamp, T. Meissner, E. Mayatepek, A. Moeltner, J. Breitkreutz, H.M. Bosse

    Acceptability of multiple uncoated mini-tablets in infants and toddlers: a randomized controlled trial

    J. Pediatr. 201: 202-207 (2018)

  • I. Speer, D. Steiner, Y. Thabet, J. Breitkreutz, A. Kwade

    Comparative study on disintegration methods for oral film preparations

    Eur. J. Pharm. Biopharm. 132: 50-61 (2018)

  • Y. Thabet, R. Sibanc, J. Breitkreutz

    Printing pharmaceuticals by inkjet technology: Proof of concept for stand-alone and continuous in-line printing on orodispersible films

    J. Manuf. Process. 35: 205-2015 (2018)

  • F.P. Fernandes, A.C. Fortes, S.G. Fonseca, J. Breitkreutz, H.G. Ferraz

    Manufacture and characterization of mucoadhesive buccal films based on pectin and gellan gum containing triamcinolone acetonide

    Int. J. Polym. Sci., Article ID 2403802 (2018)

  • I. Speer, M. Preis, J. Breitkreutz

    Prolonged drug release properties for orodispersible films by combining hot-melt extrusion and solvent casting methods

    Eur. J. Pharm. Biopharm. 129: 66-73 (2018)

  • Y. Thabet, D. Lunter, J. Breitkreutz

    Continuous ink-jet printing of enalapril maleate onto orodispersible film formulations

    Int. J. Pharm. 546: 180-187 (2018)

  • Y. Thabet, D. Lunter, J. Breitkreutz

    Continuous manufacturing and analytical characterization of fixed-dose, multilayer orodispersible films

    Eur. J. Pharm. Sci. 117: 236–244 (2018)

  • J. Peters, W. Taute, C. Döscher, R. Meier, M. Höft, R. Knöchel, J. Breitkreutz

    From laboratory- to pilot-scale: moisture monitoring in fluidized bed granulation by a novel microwave sensor using multivariate calibration approaches

    Drug Dev. Ind. Pharm. 44: 961-968 (2018)

  • Y. Thabet, J. Walsh, J. Breitkreutz

    Flexible and precise dosing of enalapril maleate for all paediatric age groups utilizing orodispersible minitablets

    Int. J. Pharm. 541: 136-142 (2018)

  • Y. Thabet, M. Slavkova, J. Breitkreutz

    10 years EU regulation of paediatric medicines – Impact on cardiovascular drug formulations

    Exp. Opin. Drug Deliv. 15: 261-270 (2018)

  • G.F. Petrovick, J. Breitkreutz

    Spheronization of solid lipid extrudates: Elucidation of spheroid formation mechanism

    Eur. J. Pharm. Biopharm. 125: 148-158 (2018)

  • J. Peters, A. Teske, W. Taute, C. Döscher, M. Höft, R. Knöchel, J. Breitkreutz

    Real-time process monitoring in a semi-continuous fluid-bed dryer – microwave resonance technology versus near-infrared spectroscopy

    Int. J. Pharm. 537: 193-201 (2018)

  • G.F. Petrovick, P. Kleinebudde, J. Breitkreutz

    Orodispersible tablets containing taste-masked solid lipid pellets with metformin hydrochloride: Influence of process parameters on tablet properties

    Eur. J. Pharm. Biopharm. 122: 137-145 (2018)

  • Y. Thabet, J. Breitkreutz

    Orodispersible films: Product transfer from lab-scale to continuous manufacturing

    Int. J. Pharm. 535: 285-292 (2018)






  • M. Münster, C. Schoch, C. Schmidt, J. Breitkreutz

    Multiparticulate system combining taste masking and immediate release properties for the aversive compound praziquantel

    Eur. J. Pharm. Sci. 109: 446-454 (2017)

  • S. Lindert, J. Breitkreutz

    Oromucosal multilayer films for tailor-made, controlled drug delivery

    Expert Opin. Drug Deliv. 14: 1265-1279 (2017)

  • M. Münster, A.H.A. Mohamed-Ahmed, L.I. Immohr, C. Schoch, C. Schmidt, C. Tuleu, J. Breitkreutz

    Comparative in vitro and in vivo taste assessment of liquid praziquantel formulations

    Int. J. Pharm. 529: 310-318 (2017)


  • J. Peters, K. Bartscher, C. Döscher, W. Taute, M. Höft, R. Knöchel, J. Breitkreutz

    In-line moisture monitoring in fluidized bed granulation using a novel multi-resonance microwave sensor

    Talanta 170: 369-376 (2017)

  • J. Peters, W. Taute, K. Bartscher, C. Döscher, M. Höft, R. Knöchel, J. Breitkreutz

    Design, development and method validation of a novel multi-resonance microwave sensor for moisture measurement

    Anal. Chim. Acta 961: 119-127 (2017)

  • M. Preis, J. Breitkreutz

    Pediatric Drug Development and Dosage Form Design

    AAPS PharmSciTech 18: 239-240 (2017)













  • V. Klingmann, Y. Thabet, J. Breitkreutz

    Arzneiformen für Kinder

    Pharmakon 4: 134-140 (2016)

  • L.H.E. Leithold, N. Jiang, J. Post, N. Niemietz, E. Schartmann, T. Ziehm, J. Kutzsche, N. J. Shah; J. Breitkreutz; K.J. Langen, A. Willuweit, D. Willbold

    Pharmacokinetic properties of tandem D-peptides designed for treatment of Alzheimer's disease

    Eur. J. Pharm. Sci. 89: 31-38 (2016)

  • G.F. Petrovick, J. Breitkreutz, M. Pein

    Taste-masking properties of solid lipid based micropellets obtained by cold extrusion-spheronization

    Int. J. Pharm. 506: 361-370 (2016)


  • R. Krampe, J.C. Visser, H.W. Frijlink, J. Breitkreutz, H.J. Woerdenbag, M. Preis

    Oromucosal film preparations: points to consider for patient centricity and manufacturing processes

    Expert Opin. Drug Deliv. 13:493-506 (2016)

  • L.H.E. Leithold, N. Jiang, J. Post, T. Ziehm, E. Schartmann, J. Kutzsche, N.J. Shah, J. Breitkreutz, K.-J. Langen, A. Willuweit, D. Willbold

    Pharmacokinetic properties of a novel D-peptide developed to be therapeutically active against toxic ß-amyloid oligomers

    Pharm. Res. 33: 328-336 (2016)

  • A. de Beaumais Tiphaine, L.L. Hjalgrim, J. Nersting, J. Breitkreutz, B. Nelken, M. Schrappe, M. Stanulla, C. Thomas, Y. Bertrand, G. Leverger, A. Baruchel, K. Schmiegelow, E. Jacqz-Aigrain

    Evaluation of a pediatric liquid formulation to improve 6-mercaptopurine therapy

    in children

    Eur. J. Pharm. Sci. 83: 1-7 (2016)

  • E.J. Laukamp, K. Knop, M. Thommes, J. Breitkreutz

    Micropellet-loaded rods with dose-independent sustained release properties for individual dosing via the Solid Dosage Pen

    Int. J. Pharm., 499: 271-279 (2016)

  • R. Krampe, D. Sieber, M. Pein, J. Breitkreutz

    A new biorelevant dissolution method for orodispersible films

    Eur. J. Pharm. Biopharm. 98: 20-25 (2016)





  • V. Klingmann, A. Seitz, T. Meissner, J. Breitkreutz, A. Moeltner, H.M. Bosse

    Acceptability of uncoated minitablets in neonates – a randomized controlled trial

    J. Pediatr. 167: 893-896 (2015)


  • M. Preis, J. Breitkreutz, N. Sandler

    Perspective: Concepts of printing technologies for oral film formulations

    Int. J. Pharm. 494: 578-84 (2015)


  • N. Jiang, L.H.E. Leithold, J. Post, T. Ziehm, J. Mauler, K.-J. Langen, J. Breitkreutz, D. Willbold, A. Willuweit

    Preclinical pharmacokinetic studies of the tritium labelled D-enantiomeric peptide

    D3 developed for the treatment of Alzheimer´s disease

    PLoS One 10(6): e0128553 (2015)


  • M. Rohrschneider, S. Bhagwat, R. Krampe, V. Michler, J. Breitkreutz, G. Hochhaus

    Evaluation of the Transwell® system for characterization of dissolution behavior of inhalation drugs: Effects of membrane and surfactant

    Mol. Pharm. 12: 2618-24 (2015)


  • J. Walsh, M.C. Math, J. Breitkreutz, T. Zerback, H. Wachtel

    Devices for oral and respiratory paediatric medicines: What do healthcare

    professionals think?

    Int. J. Pharm. 492: 304-315 (2015)


  • M. Preis, L. Grother, P. Axe, J. Breitkreutz

    In-vitro and in-vivo evaluation of taste-masked cetirizine hydrochloride formulated

    in oral lyophilisates

    Int. J. Pharm. 491: 8-16 (2015)


  • M. Slavkova, J. Breitkreutz

    Orodispersible drug formulations for children and elderly

    Eur. J. Pharm. Sci. 75: 2-9 (2015)


  • M. Guhmann, M. Preis, F. Gerber. N. Pöllinger, J. Breitkreutz, W. Weitschies

    Design, development and in vitro evaluation of diclofenac taste-masked

    orodispersible tablet formulations

    Drug Dev. Ind. Pharm. 41: 540-551 (2015)


  • J.C. Visser, W.M.C. Dohmen, W.L.J. Hinrichs, J. Breitkreutz, H.W. Frijlink, H.J. Woerdenbag

    Quality by design approach for optimizing the formulation and physical properties

    of extemporaneously prepared orodispersible films?

    Int. J. Pharm. 485: 70-76 (2015)


  • G. Petrovick, M. Pein, M. Thommes, J. Breitkreutz

    Spheronization of solid small lipid extrudates: an innovative approach in

    process control

    Eur. J. Pharm. Biopharm. 92: 15-21 (2015)


  • B. Coulibaly, M. Pritsch, M. Bountogo, P.E. Meissner, E. Nebié, C. Klose, M. Kieser, N. Berens-Riha, A. Wieser, S.B. Sirima, J. Breitkreutz, R.H. Schirmer, A. Sié, F.P. Mockenhaupt, C. Drakeley, T. Bousema, O. Müller

    Efficacy and safety of triple combination therapy with artesunate-amodiaquine- methylene blue for falciparum malaria in children: a randomized controlled

    trial in Burkina Faso

    J. Infect. Dis. 211: 689-697 (2015)

  • E M. Laukamp, A.K. Vynckier, J. Voorspels, M. Thommes, J. Breitkreutz

    Development of sustained and dual drug release co-extrusion formulations for individual dosing

    Eur. J. Pharm. Biopharm. 89: 357-364 (2015)

  • C.M. Wagner, M. Pein, J. Breitkreutz

    Roll compaction of granulated mannitol grades and the unprocessed crystalline delta-polymorph

    Powder Technol. 270: 470-475 (2015)

  • J.C. Visser, H.J. Woerdenbag, S. Crediet, E. Gerrits, M.A. Lesschen, W.L.J. Hinrichs, J. Breitkreutz, H.W. Frijlink

    Orodispersible films in individualized pharmacotherapy: the development of a formulation for pharmacy preparations

    Int. J. Pharm. 478: 155-163 (2015)




  • C. Eckert, M. Pein, J. Breitkreutz

    Lean production of taste masked lipidic sodium benzoate formulations

    Eur. J. Pharm. Biopharm. 88: 455-461 (2014)

  • E M. Laukamp, M. Thommes, J. Breitkreutz

    Hot-Melt Extruded Drug-Loaded Rods: Evaluation of the Mechanical Properties for Individual Dosing via the Solid Dosage Pen

    Int. J. Pharm. 275: 344-350 (2014)

  • M. Preis, D. Gronkowsky, D. Grytzan, J. Breitkreutz

    Comparative study on novel test systems to determine disintegration time of orodispersible films

    J. Pharm. Pharmacol. 66: 1102-1111 (2014)

  • M. Preis, O. Häusler, J. Breitkreutz

    Electronic tongues in preformulation studies - Application of electronic tongues in preformulations studies to evaluate taste-masking capacities of maltodextrins

    Pharm. Ind. 76: 957-962 (2014)

  • J. Walsh, A. Cram, C. Tuleu, G. Winzenburg, R. Turner, K. Woertz, J. Breitkreutz

    Playing hide and seek with poorly tasting paediatric medicines: do not forget the excipients

    Adv. Drug Deliv. Rev. 73: 14-33 (2014)

  • M. Preis, C. Woertz, K. Schneider. J. Kukawka, J. Breitkreutz

    Bilayer oromucosal film preparations for local administration of lidocaine hydrochloride

    Eur. J. Pharm. Biopharm. 86: 552-561 (2014)

  • S. Lindert, A. Below, J. Breitkreutz

    Performance of dry powder inhalers with single dosed capsules in preschool children and adults using improved upper airway models

    Pharmaceutics 6: 36-51 (2014)

  • M. Preis, C. Eckert, O. Häusler, J. Breitkreutz

    A comparative study on solubilizing and taste-masking capacities of hydroxypropyl-ß-cyclodextrin and maltodextrins with high amylose content

    Sensors & Actuators B 193: 442-450 (2014)

  • M. Preis, K. Knop, J. Breitkreutz

    Mechanical strength test for orodispersible and buccal films

    Int. J. Pharm. 461: 22-29 (2014)






  • S. Just, F. Sievert, M. Thommes, J. Breitkreutz

    Improved group contribution parameter set for the application of solubility parameters to melt extrusion

    Eur. J. Pharm. Biopharm. 85: 1191-1199 (2013)

  • N. Genina, E.M. Janßen, A. Breitenbach, J. Breitkreutz, N. Sandler

    Evaluation of different substrates for inkjet-printing of rasagiline mesylate substrates

    Eur. J. Pharm. Biopharm. 85: 1075-1083 (2013)

  • C. Woertz, M. Preis, J. Breitkreutz, P. Kleinebudde

    Assessment of test methods evaluating mucoadhesive polymers and dosage forms:

    an overview

    Eur. J. Pharm. Biopharm. 85: 843-853 (2013)

  • V. Klingmann, N. Spomer, C. Lerch, I. Stoltenberg, C. Frömke, H.M. Bosse, J. Breitkreutz,

    T. Meissner

    Favourable acceptance of mini-tablets compared with syrup: a randomised

    controlled trial in infants and preschool children

    J. Pediatr. 163:1728-1732 (2013)

  • B. Kollar, J. Breitkreutz, W. Wiedey, K. Bartscher, C. Döscher

    Innovative Mikrowellenresonanz-Sensoren für die Messung in Wirbelschichtgeräten

    TechnoPharm 3: 317-321 (2013)

  • A. Zajicek, M.J. Fossler, J.S. Barrett, J.H. Worthington, R. Ternik, G. Charkoftaki, S. Lum,

    J. Breitkreutz, M. Baltezor, P. Macheras, M. Khan, S. Agharkar, D.D. MacLaren

    A report from the Pediatric Formulations Task Force: Perspectives on the state of child-friendly oral dosage forms

    AAPS J. 15: 1072-1081 (2013)

  • M. Haupt, M. Thommes, A. Heidenreich, J. Breitkreutz

    Lipid-based intravesical drug delivery systems with controlled release of trospium chloride for the urinary bladder

    J. Control. Rel. 170: 161-166 (2013)

  • M. Preis, C. Wörtz, P. Kleinebudde, J. Breitkreutz

    Characterization of oromucosal film preparations

    Exp. Opin. Drug Deliv. 10: 1303-1317 (2013)

  • C.M. Wagner, M. Pein, J. Breitkreutz

    Roll compaction of mannitol: Compactability study of crystalline and spray-dried grades

    Int. J. Pharm. 453: 416-422 (2013)

  • M. Pein, C. Eckert, M. Preis, J. Breitkreutz

    New protocol for Astree electronic tongue enabling full performance qualification according to ICH Q2 using caffeine citrate as model substance

    J. Pharm. Biomed. Anal. 83: 157-163 (2013)

  • M. Guhmann, M. Thommes, F. Gerber, N. Pöllinger, S. Klein, J. Breitkreutz, W. Weitschies

    Design of biorelevant test setups for the prediction of diclofenac in vivo features after oral administration

    Pharm. Res. 30: 1483-1501 (2013)

  • C. Eckert, M. Pein, J. Reimann, J. Breitkreutz

    Taste evaluation of multicomponent mixtures using a human taste panel, electronic taste sensing systems and HPLC

    Sensors and Actuators B 182: 294-299 (2013)

  • A. Below, D. Bickmann, J. Breitkreutz

    Assessing the performance of two dry powder inhalers in preschool children using an idealized upper airway model

    Int. J. Pharm. 444: 169-174 (2013)

  • E.M. Janßen, R. Schliephacke, A. Breitenbach, J. Breitkreutz

    Drug-printing by Flexography – a new manufacturing process for orodispersible films

    Int. J. Pharm. 441: 818-825 (2013)






  • N. Guffon, Y. Kibleur, W. Coppalu, C. Tissen, J. Breitkreutz
    Studies of a new formulation of sodium phenylbutyrate
    Arch. Dis. Child. 97: 1081-1085 (2012)

  • K. Wening, E.J. Laukamp, M. Thommes, J. Breitkreutz
    Individual oral therapy with immediate release and  effervescent formulations delivered by the Solid Dosage Pen
    J. Pers. Med. 2: 217-231 (2012)

  • M. Preis, M. Pein, J. Breitkreutz
    Development of a taste-masked orodispersible film containing dimenhydrinate
    Pharmaceutics 4: 551-562 (2012)

  • M. Guhmann, M. Preis, F. Gerber, N. Pöllinger, J. Breitkreutz, W. Weitschies
    Development of oral taste masked diclofenac formulations using a taste sensing system
    Int. J. Pharm. 438: 81-90 (2012)

  • C. Kindermann, K. Matthée, F. Sievert, J. Breitkreutz
    Electrolyte-stimulated biphasic dissolution profile and stability enhancement for tablets containing drug-polyelectrolyte complexes
    Pharm. Res. 29: 2710-2721 (2012)

  • T. Ernest, J. Craig, A. Nunn, S. Salunke, C. Tuleu, J. Breitkreutz, R. Alex, J. Hempenstall
    Preparation of medicines for children – a hierachy of classification
    Int. J. Pharm. 435: 124-130 (2012)

  • S. Stegemann, M. Gogol, J. Breitkreutz
    Swallowing dysfunction and dysphagia is an unrecognized challenge for oral drug therapy
    Int. J. Pharm. 430: 197-206 (2012)

  • J. Vaassen, K. Bartscher, J. Breitkreutz
    Taste masked lipid pellets with enhanced release of hydrophobic active ingredient
    Int. J. Pharm. 429: 99-103 (2012)

  • N. Spomer, V. Klingmann, I. Stoltenberg, C. Lerch, T. Meissner, J. Breitkreutz
    Acceptance of uncoated mini-tablets in young children – Results from a prospective exploratory cross-over study
    Arch. Dis. Child. 97: 283-286 (2012)



  • K. Woertz, C. Tissen, P. Kleinebudde, J. Breitkreutz
    Development of a taste masked generic ibuprofen suspension - Top down approach guided by electronic tongue measurements
    J. Pharm. Sci. 100: 4460-4470 (2011)

  • K. Woertz, C. Tissen, P. Kleinebudde, J. Breitkreutz
    Taste sensing systems (electronic tongues) for pharmaceutical applications
    Int. J. Pharm. 417: 256-271 (2011)

  • C. Tissen, K. Woertz, J. Breitkreutz, P. Kleinebudde
    Development of mini-tablets with 1 mm and 2 mm diameter
    Int. J. Pharm. 416: 164-170 (2011)

  • I. Stoltenberg, J. Breitkreutz
    Orally disintegrating mini-tablets (ODMTs) - A novel solid dosage form for paediatric use
    Eur. J. Pharm. Biopharm. 78: 462-469 (2011)

  • J. Walsh, D. Bickmann, J. Breitkreutz, M. Chariot-Goulet
    Delivery devices for the administration of paediatric formulations: Overview of current practice, challenges and recent developments
    Int. J. Pharm. 415: 221-231 (2011)

  • C. Eckert, C. Lutz, J. Breitkreutz, K. Woertz
    Quality control of oral herbal products by an electronic tongue - a case study on sage lozenges
    Sensors and Actuators B 156: 204-212 (2011)

  • J. Breitkreutz, J. Boos
    Drug delivery and formulations
    in: H.W. Seyberth, A. Rane, M. Schwab (eds.): Handbook of Experimental Pharmacology, Vol. 205: Paediatric Clinical Pharmacology, S. 91-107, Springer-Verlag, Berlin Heidelberg (2011)

  • K. Woertz, C. Tissen, P. Kleinebudde, J. Breitkreutz
    A comparative study on two electronic tongues for pharmaceutical formulation development
    J. Pharm. Biomed. Anal. 55: 272-281 (2011)

  • E.M. Hoffmann, A. Breitenbach, J. Breitkreutz
    Advances in orodispersible films for drug delivery
    Exp. Opin. Drug Deliv. 8: 299-316 (2011)

  • K. Wening, J. Breitkreutz
    Oral drug delivery in personalized medicine: Unmet needs and novel approaches
    Int. J. Pharm. 404: 1-9 (2011)


  • K. Woertz, C. Tissen, P. Kleinebudde, J. Breitkreutz
    "Qualification of an electronic tongue according to ICH guideline Q2"
    J. Pharm. Biomed. Anal. 51: 497-506 (2010)

  • K. Woertz, C. Tissen, P. Kleinebudde, J. Breitkreutz
    "Rational development of taste masked oral liquids guided by an electronic tongue"
    Int. J. Pharm. 400: 114-123 (2010)

  • S. Stegemann, F. Ecker, M. Maio, P. Kraahs, J. Breitkreutz, A. Zimmer, D. Bar-Shalom, P. Hettrich
    "Geriatric drug therapy: neglecting the inevitable majority"
    Ageing Res. Rev. 9: 384-398 (2010)

  • M. Hermes, L. Barnscheid, V. Garsuch, P. Schoettler, J. Breitkreutz
    "Arzneimittelversorgung von Kindern – Ergebnisse einer Studie zur praktischen Auswirkung der EU-Verordnung 1901/2006 „Better Medicines for Children“ seit dem Inkrafttreten im Januar 2007"
    Pharm. Ind. 72: 1334-1344 (2010)

  • I. Stoltenberg, G. Winzenburg, J. Breitkreutz
    "Solid oral dosage forms for children – formulations, excipients and acceptance issues"
    J. Appl. Ther. Res. 7: 141-146 (2010)

  • K. Wening, J. Breitkreutz
    "Novel delivery device for monolithical solid oral dosage forms for personalized medicine"
    Int. J. Pharm. 395: 174-181 (2010)

  • V. Garsuch, J. Breitkreutz
    "Comparative investigations on different polymers for the manufacturing of fast-dissolving oral films"
    J. Pharm. Pharmacol. 62: 539-545 (2010)

  • K. Woertz, C. Tissen, P. Kleinebudde, J. Breitkreutz
    "Performance qualification of an electronic tongue according to ICH guideline Q2"
    J. Pharm. Biomed. Anal. 51: 497-506 (2010)

  • S. Ramusovic, S. Läer, J. Breitkreutz
    "Bosentan in der Pädiatrie"
    Pharm. Unserer Zeit 39: 454-458 (2010)

  • I. Stoltenberg, G. Winzenburg, J. Breitkreutz
    "Solid oral dosage forms for children – formulations, excipients and acceptance issues"
    Ind. Pharm. 27: 15-18 (2010)

  • J. Breitkreutz, W. Friess
    "Kindgerechte Arznieimittel mit gentechnisch hergestellten Wirkstoffen"
    Annual Biotech-Report VfA, 46 (2010)

  • I. Stoltenberg, J. Breitkreutz
    "Ludiflash®- preparation and characterization of orally disintegrating mini-tablets for pediatric use"
    ExAct 24: 7-10 (2010)

  • J. Breitkreutz, W. Frieß
    "Kindgerechte Arzneimittel mit gentechnisch hergestellten Wirkstoffen"
    In: D. Michl, A. Heinemann (eds.): Medizinische Biotechnologie in Deutschland 2010 BCG GmbH, München (2010)

  • J. Breitkreutz
    "Schnell zerfallende orale Arzneiformen"
    in K. Mäder, U. Weidenauer (eds.): Innovative Arzneiformen, Wissenschaftliche Verlagsgesellschaft, Stuttgart, ISBN-13: 978-3-8047-2455-6 (2010)

  • P. Rohdewald, G. Rücker, K.W. Glombitza, bearbeitet von J. Breitkreutz, K.W. Glombitza, G. Rücker, M.A. Hubert
    "Apothekengerechte Prüfvorschriften"
    Deutscher Apotheker Verlag, Stuttgart 13. Erg.-Lieferung (2010): ISBN 978-3-7692-5192-0



  • C. Buschmüller, W. Wiedey, C. Döscher, M. Plitzko, J. Breitkreutz
    "In-line monitoring of granule moisture and temperature throughout the entire fluidized-bed granulation process using microwave resonance technology"
    Part I: Pharm. Ind. 71: 1403-1408 (2009)
    Part II: Pharm. Ind. 71: 1614-1620 (2009)

  • V. Garsuch, J. Breitkreutz
    "Novel analytical methods for the characterization of oral wafers"
    Eur. J. Pharm. Biopharm. 73:195-201 (2009)

  • J. Krause, M. Thommes, J. Breitkreutz
    "Immediate release pellets with lipid binders obtained by solvent-free cold extrusion"
    Eur. J. Pharm. Biopharm. 71: 138-144 (2009)

  • A. Cram, J. Breitkreutz, S. Desset-Brèthes, T. Nunn, C. Tuleu
    "Challenges of developing palatable oral paediatric formulations"
    Int. J. Pharm. 365: 1-3 (2009)

  • J. Breitkreutz
    "Excipients for paediatric use"
    Bulletin Technique Gattefossé 102: 71-75 (2009)

  • J. Breitkreutz
    "Pharmazeutisch-technologische und biopharmazeutische Aspekte der Thrombozytenaggregationshemmer"
    Pharm. Unserer Zeit 38: 330-337 (2009)

  • J. Breitkreutz
    "Arzneiformen für Kinder"
    Pharm. Unserer Zeit 38: 30-37 (2009)

  • P. Rohdewald, G. Rücker, K.W. Glombitza, bearbeitet von J. Breitkreutz, K.W. Glombitza, G. Rücker, M.A. Hubert
    "Apothekengerechte Prüfvorschriften"
    Deutscher Apotheker Verlag, Stuttgart 12. Erg.-Lieferung (2009): ISBN 978-3-7692-4192-1

  • J. Breitkreutz
    "Schnell zerfallende orale Arzneiformen"
    in C. Mäder, U. Weidenauer (eds.): Innovative Arzneiformen, 3. Aufl., Wissenschaftliche Verlagsgesellschaft, Stuttgart, ISBN-13: 978-3-8047-2455-6 (2009)



  • J. Breitkreutz
    "European perspectives on pediatric formulations"
    Clin. Ther. 30: 2146-2154 (2008)
  • C. Buschmüller, W. Wiedey, C. Döscher, J. Dressler, J. Breitkreutz
    "In-line monitoring of granule moisture in fluidized bed dryers using Microwave Resonance Technology"
    Eur. J. Pharm. Biopharm. 69: 380-387 (2008)
  • J. Krause, J. Breitkreutz
    "Improving drug delivery in pediatric medicine"
    Pharm. Med. 22: 41-50 (2008)
  • J. Breitkreutz
    "Die elektronische Zunge. Geschmacksvorhersage mittels Chemosensorenarray-System"
    GIT Labor-Fachzeitschrift 3/2008, 257
  • J. Breitkreutz
    "Geschmacksmaskierung – Bittere Arzneistoffe gut kaschiert"
    Pharm. Ztg., 153: 376-383 (2008)
  • J. Breitkreutz
    "Geschmacksmaskierung und andere galenische Tricks zur Verbesserung der Compliance"
    Pharm. Ztg. 153 Suppl. 1: 6-9 (2008)
  • J. Breitkreutz, R. Eifler-Bollen, A. Kiefer
    "Fit für die Rezeptur – Ein Trainingsbuch für das Apothekenteam"
    Govi-Verlag, Eschborn; 1. Auflage (2008): ISBN-13:978-3-7741-1074-8 



  • J. Breitkreutz, J. Boos
    "Paediatric and geriatric drug delivery"
    Exp. Opin. Drug Deliv. 4: 37-45 (2007)
  • J. Breitkreutz, T. G. Gan, B. Schneider, P. Kalisch
    "Enteric-coated solid dosage forms containing sodium bicarbonate as a drug substance: an exception from the rule? "
    J. Pharm. Pharmacol. 59: 59-65 (2007)
  • J. Breitkreutz, C. Tuleu, D. Solomonidou
    "Paediatric formulations"
    In: K. Rose, J. N. van den Anker (Hrsg.): Guide to paediatric clinical research, 65-77, S. Karger AG, CH-Basel, (2007) ISBN-13: 978-3-8055-8201-8 
  • K. Grießmann, J. Breitkreutz, M. Schubert-Zsilavecz, M. Abdel Tawab
    "Dosing accuracy of measuring devices provided with antibiotic oral suspensions"
    Paed. Perinat. Drug Ther. 8: 61-70 (2007)
  • J. Breitkreutz, J. Buckham, M. Fischer, R. Pöstges, J. Boos
    "Comparative in vitro-studies on different 6-mercaptopurine formulations for the use in children"
    Paed. Perinat. Drug Ther. 8: 31-39 (2007)
  • J. Breitkreutz, U. Holzgrabe, P. Kleinebudde, K. Michel, A. Ritter, F. Stieneker"
    Wann Tabletten geteilt werden dürfen"
    Dtsch. Apoth. Ztg. 147: 2854-2855 (2007)



  • J. Breitkreutz
    "Arzneizubereitungen für Kinder"
    Pharm. Ztg. 151 Suppl.: 21-24 (2006)
  • L. Barnscheid, J. Kakkanattuparambil, H. Yildirim, J. Breitkreutz
    "Hydrochlorothiazid – Kapsel-Herstellung auf dem Prüfstand"
    Pharm. Ztg. 151: 4812-4816 (2006)
  • J. Breitkreutz
    "Rezepturarzneimittel im Krankenhaus – Erste systematische Auswertung von Verordnungsdaten"
    Management & Krankenhaus (11): 29 (2006)
  • S. Läer, K. G. Schmidt, J. Breitkreutz
    "Europäische Union zeigt Herz für Kinder"
    Cardio News 9 (7-8): 33 (2006)
  • K. Grießmann, J. Breitkreutz, P. Schoettler, M. Schubert-Zsilavecz, M. Tawab
    "Dosiergenauigkeit und sichere Anwendung von Amoxicillintrockensäften"
    päd Praktische Pädiatrie 8: 266-271 (2006)
  • M. Bonati, J. Breitkreutz, I. Choonara, K. Hoppu, E. Jacqz-Aigrain, J.-P. Langhendries, G. Pons, A. Rane, H. Seyberth, J. van den Anker
    "Paediatric clinical pharmacology in Europe"
    Paed. Perinat. Drug Ther. 7: 134-137 (2006)
  • P. Rohdewald, G. Rücker, P. Glombitza, unter Mitarbeit von J. Breitkreutz
    "Apothekengerechte Prüfvorschriften"
    11. Erg.-Lieferung Deutscher Apotheker Verlag, Stuttgart (2006; ISBN 3-7692-4191-6
  • J. Breitkreutz
    "Colestyramin Ph. Eur. 5.0"
    Kommentar zum Europäischen Arzneibuch, Wiss. Verlagsges. Stuttgart (2006);
    ISBN 3-8047-2268-7 (Akt.-lieferung), ISBN 3-8047-2269-5 (Grundwerk)
  • J. Breitkreutz
    "Kindgerechte Arzneizubereitungen"
    In: A. Labisch (Hrsg.): Jahrbuch der Heinrich-Heine-Universität Düsseldorf 2005/2006, S. 161-172
    Heinrich-Heine-Universität, Düsseldorf (2006); ISBN 3-9808514-4-3
  • J. Breitkreutz
    "Novel approaches to the route of administration"
    In E. Jacqz-Aigrain, I. Choonara (Hrsg.): Paediatric Clinical Pharmacology. 235-243,
    1. Aufl., FontisMedia S.A., CH-Lausanne and  Taylor & Francis, US-New York (2006), ISBN 0-8247-2189-6



  • K. Grießmann, J. Breitkreutz, P. Schoettler, M. Schubert-Zsilavecz, M. Abdel Tawab
    "Amoxicillintrockensäfte - Dosierungsgenauigkeit und sichere Handhabung"
    Monatsschr. Kinderheilkd. 153: 735-740 (2005) 
  • J. Breitkreutz
    "Kindgerechte Arzneiformen - Neue Produkte und Entwicklungsprojekte"
    Monatsschr. Kinderheilkd. 153: 726-734 (2005)
  • J. Breitkreutz
    "Was zeichnet kindgerechte Arzneimittel aus?"
    Der Allgemeinarzt 42-44 (2005)
  • J. Breitkreutz
    "Pharmazeutisch-technologische und biopharmazeutische Aspekte der Arzneizubereitungen mit Protonenpumpenhemmern"
    Pharm. Unserer Zeit 34: 216-223 (2005) 



  • J. Breitkreutz
    "Kindgerechte Arzneizubereitungen zur peroralen Anwendung"
    Habilitationsschrift, Universität Münster (2004)
  • R.S. Müller, J. Breitkreutz, R. Gröning
    "Interactions between aqueous Hypericum perforatum extracts and drugs: in vitro studies"
    Phytother. Res. 18: 1019-1023 (2004)
  • H. Neye, J. Breitkreutz
    "Spezielle Aspekte der Arzneimitteltherapie in Kindheit und Alter"
    Med. Monatsschr. Pharm. 27: 161-167 (2004)



  • J. Breitkreutz, F. El-Saleh, C. Kiera, P. Kleinebudde, W. Wiedey
    "Pediatric drug formulations of sodium benzoate: II. Coated granules with a lipophilic binder"
    Eur. J. Pharm. Biopharm. 56: 255-260 (2003)
  • C. Reinke, J. Breitkreutz, H. Leuenberger
    "Aluminium in drugs - risks outweigh benefits ?"
    Drug Safety (2003)
  • J. Breitkreutz, M. Bornhöft, F. Wöll, P. Kleinebudde
    "Pediatric drug formulations of sodium benzoate: I. Coated granules with a hydrophilic binder"
    Eur. J. Pharm. Biopharm. 56: 247-253 (2003)
  • R. Gröning, J. Breitkreutz, R.S. Müller
    "Physico-chemical interactions between extracts of Hypericum perforatum L. and drugs"
    Eur. J. Pharm. Biopharm. 56: 231-236 (2003)
  • B. Chankvetadze, K. Lomsadze, N. Burjanadze, J. Breitkreutz, G. Pintore, M. Chessa, K. Bergander, G. Blaschke
    "Comparative enantioseparations with native b-cyclodextrin, randomly acetylated b-cyclodextrin and heptakis-(2,3-di-O-acetyl)-b-cyclodextrin in capillary electrophoresis"
    Electrophoresis 24: 1083-1091 (2003)
  • J. Breitkreutz, T. Wessel, J. Boos
    "13. Dosage forms for oral drug administration"
    In I. Choonara, T. Nunn, G. Kearns (Hrsg.): Introduction to paediatric and perinatal drug therapy, 189-205
    1.Aufl., Nottingham University Press (2003), ISBN 1-897676-37-9



  • B. Chankvetadze, N. Burjanadze, J. Breitkreutz, K. Bergander, D. Bergenthal, O. Kataeva, R. Fröhlich, H. Luftmann, G. Blaschke
    "Mechanistic study on the opposite migration order of the enantiomers of ketamine with alpha- and beta-cyclodextrins in capillary electrophoresis"
    J. Sep. Sci. 25: 1155-1166 (2002)
  • J. Breitkreutz, J. Boos, P. Kleinebudde
    "Kindgerechte Darreichungsformen - Arzneimitteltherapie für alle"
    Pharm. Ztg. 147: 16-24 (2002)
  • R. Gröning, J. Breitkreutz, V. Baroth, R.S. Müller
    "Nanoparticles in plant extracts - influence of drugs on the formation of nanoparticles and precipitates in black tea infusions"
    Eur. J. Pharm. Sci. 15: 149-155 (2002)
  • J. Breitkreutz
    "Kindgerechte Darreichungsformen"
    In Health Care NRW e.V. (Ed.): Arzneimittel für Kinder und Jugendliche - aktueller Stand und Entwicklungsmöglichkeiten 12-13 (2002)



  • R. Gröning, J. Breitkreutz, V. Baroth, R.S. Müller
    "Nanoparticles in plant extracts - factors which influence the formation of nanoparticles in black tea infusions"
    Pharmazie 56: 790-792 (2001)
  • W. Weitschies, R. Grützmann, V. Hartmann, J. Breitkreutz
    "Determination of the disintegration behaviour of magnetically marked tablets"
    Eur. J. Pharm. Biopharm. 52: 221-226 (2001)
  • B. Chankvetadze, I. Kartozia, J. Breitkreutz, Y. Okamoto, G. Blaschke
    "Effect of organic solvent, electrolyte salt and a loading of cellulose tris(3,5-dichlorophenylcarbamate) on silica gel on enantioseparation characteristics in capillary electrochromatography"
    Electrophoresis 22: 3327-3334 (2001)
  • B. Chankvetadze, K. Lomsadze, D. Bergenthal, J. Breitkreutz, K. Bergander, G. Blaschke
    "Mechanistic study on the opposite migration order of clenbuterol enantiomers in capillary electrophoresis with beta-CD and single isomer heptakis-(2,3-diacetyl-6-sulfo)-beta-cyclodextrin"
    Electrophoresis 22: 3178-3184 (2001)
  • T. Wessel, J. Breitkreutz, E. Ahlke, G. Hempel, J. Boos
    "Probleme in der Dauertherapie mit Mercaptopurin-Tabletten"
    Krankenhauspharmazie 22: 325-329 (2001)
  • W. Weitschies, M. Karaus, D. Cordini, L. Trahms, J. Breitkreutz, W. Semmler
    "Magnetic marker monitoring of disintegrating capsules"
    Eur. J. Pharm. Sci. 13: 411-416 (2001)
  • B. Chankvetadze, I. Kartozia, J. Breitkreutz, M. Girod, M. Knobloch, Y. Okamoto, G. Blaschke
    "Comparative capillary chromatographic and capillary electrochromatographic enantioseparations using cellulose tris(3,5-dichlorophenylcarbamate) as a chiral stationary phase"
    J. Sep. Sci. 24: 251-257 (2001)
  • J. Breitkreutz, G. Heun
    "Grundlagen der Physikalischen Chemie für Pharmazeuten"
    1st edition, IPT-Verlag Münster (2001), ISBN 3-9803753-5-8



  • G. Yener, Y. Topaloglu, J. Breitkreutz
    "Enhancement of dissolution of tiaprofenic acid via inclusion with skimmed milk"
    S.T.P. Pharma Sci. 10: 401-404 (2000)
  • J. Breitkreutz
    "Leakage of Enteric (Eudragit L)-Coated Dosage Forms in Simulated Gastric Juice in the Presence of Poly(ethylene glycol)"
    J. Control. Release 67: 79-88 (2000)
  • B. Chankvetadze, G. Pintore, N. Burjanadze, D. Bergenthal, K. Bergander, J. Breitkreutz, C. Mühlenbrock, G. Blaschke
    "Mechanistic study of opposite migration order of dimethindene enantiomers in capillary electrophoresis in the presence of native beta-CD and  heptakis-(2,3,6-tri-O-methyl)-beta-CD"
    J. Chromatogr. A 875: 455-469 (2000)
  • B. Chankvetadze, N. Burjanadze, G. Pintore, D. Bergenthal, K. Bergander, C. Mühlenbrock, J. Breitkreutz, G. Blaschke
    "Separation of brompheniramine enantiomers in capillary electrophoresis and study of chiral recognition mechanisms of cyclodextrins using NMR-spectroscopy, UV spectrometry, ESI-MS and x-ray crystallography"
    J. Chromatogr. A 875: 471-484 (2000)


 vor 2000

  • J. Breitkreutz, T. Wessel, J. Boos
    "Dosage Forms for Peroral Drug Administration to Children"
    Paediatr. Perinatal Drug Therap. 3: 25-33 (1999)
  • H. Bensmann, B. Borchard, J. Breitkreutz, C. Cloer, C. Drengenberg, G. Heun, E. Kuhlmann, U. Kuhland, R. Möwes, S. Remmerbach, C. Walz
    "Zukunftsorientierte Arzneimittelentwicklung - Beispiele für biomedizinisch orientierte Forschung in der Pharmazeutischen Technologie"
    Forschungsjournal der WWU Münster 7: 16-20 (1998)
  • J. Breitkreutz
    "Prediction of Intestinal Drug Absorption Properties by Three-Dimensional Solubility Parameters"
    Pharm. Res. 15: 1370-1375 (1998)
  • Y. Topaloglu, G. Yener, J. Breitkreutz
    "Preparation of sulindac with skimmed milk via freeze-drying"
    Pharmazie 53: 327-329 (1998)
  • G. Heun, J. Breitkreutz
    "Experimental and molecular modelling studies on the incompatibility of phenolic preservatives with polyethylene glycols"
    Pharm. Pharmacol. Lett. 6: 60-63 (1996)
  • J. Breitkreutz
    "Molecular Modeling-Studien und experimentelle Untersuchungen zur molekularen Struktur von Polyethylenglykolen und zu deren Wechselwirkungen mit Wasser und Phenol"
    Dissertation, Universität Münster (1996), erschienen im Shaker Verlag Aachen, ISBN 3-8265-1599-4R.
  • Gröning, V. Baroth, J. Breitkreutz
    "Nanoparticles in plant extracts - investigations into the colloidal structure of aqueous infusions of black tea"
    Pharm. Pharmacol. Lett. 2: 77-79 (1995)
  • G. Heun, J. Breitkreutz
    "Structures and molecular attributes of polyethylene glycols"
    Pharmazie 49: 562-566 (1994)
  • J. Breitkreutz
    "Entwicklung eines Computerprogramms zur rechnerunterstützten Herstellung von Augentropfen"
    Diplomarbeit, E. M. Arndt-Universität Greifswald (1992)


 Patente / Marken Prof. Dr. J. Breitkreutz

  • J. Krause, J. Breitkreutz
    "Lipid pellets with enhanced taste-masking"
    Heinrich-Heine-Universität Düsseldorf, Provendis GmbH, Mülheim; WO 2009/007047, EP 08 017 286.9, US 61/101,717

  • J. Breitkreutz, P. Kleinebudde, J. Van Hove
    "Mittel zur peroralen Verabreichung von Natriumbenzoat, seine Herstellung und Verwendung"
    German Patent Office, DE OS 101 49 652 A1 (24.04.2003)

  • J. Breitkreutz
    "Ethicare" Brandmark
    German Patent Office, Registration No. 301 60 671 (28.11.2001)

Verantwortlich für den Inhalt: E-Mail sendenProf. Breitkreutz