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Publikationen

* shared corresponding author, + shared first author

Cramer J.,*+ Aliu B.,+ Jiang X., Sharpe T., Pang L., Hadorn A., Rabbani S., Ernst B.*, Poly-L-lysine Glycoconjugates Inhibit DC-SIGN-mediated Attachment of Pandemic Viruses, ChemMedChem. 2021, https://doi.org/10.1002/cmdc.202100348. Part of the „EuroMedChem Talents” article collection

Lal K., Bermeo R., Cramer J., Vasile F., Ernst B., Imberty A., Bernardi A., Varrot A., Belvisi L., Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia cenocepacia, Chem. Eur. J. 2021, doi.org/10.1002/chem.202100252.

Cramer J., Jiang X., Schönemann W., Silbermann M., Zihlmann P., Siegrist S., Fiege B., Jakob R. P., Rabbani S., Maier T., Ernst B., Enhancing the Enthalpic Contribution of Hydrogen Bonds by Solvent Shielding, RSC Chem. Biol. 2020, 1, 281. Highlighted in „Editor’s choice” article collection

Kroezen B., Conti G., Girardi B., Cramer J., Jiang X., Rabbani S., Müller J., Kokot M., Luisoni E., Ricklin D., Schwardt O., Ernst B. A Potent Mimetic of the Siglec‐8 Ligand 6’‐Sulfo‐Sialyl Lewisx, ChemMedChem 2020, 18, 1706-1719. Front Cover and highlight as “Very Important Paper”.

Cramer J.,* Sager C. P., Ernst B.* Hydroxyl Groups in Synthetic and Natural-Product-Derived Therapeutics: A Perspective on a Common Functional Group, J. Med. Chem., 2019, 62, 8915–8930.

Schönemann W., Cramer J., Mühlethaler T., Fiege B., Silbermann M., Rabbani S., Dätwyler P., Zihlmann P., Jakob R. P., Sager C. P., Smiesko M., Schwardt O., Maier T., Ernst B. Improvement of Aglycone π-Stacking Yields Nanomolar to Sub-nanomolar FimH Antagonists, ChemMedChem, 2019, 14, 749–757. Front Cover and highlight as “Very Important Paper”.

Krimmer S. G.,+ Cramer J.,+ Schiebel J., Heine A., Klebe G. How Nothing Boosts Affinity: Hydrophobic Ligand Binding to the Virtually Vacated S1' Pocket of Thermolysin, J. Am. Chem. Soc., 2017, 139, 10419–10431. Highlighted in science blog “In the Pipeline”

Cramer J., Krimmer S. G., Heine A., Klebe G. Paying the Price of Desolvation in Solvent-Exposed Protein Pockets: Impact of Distal Solubilizing Groups on Affinity and Binding Thermodynamics in a Series of Thermolysin Inhibitors, J. Med. Chem., 2017, 60, 5791–5799. Highlighted by F1000 prime

Cramer J., Schiebel J., Wulsdorf T., Grohe K., Najbauer E., Ehrmann F. R., Radeva N., Zitzer N., Linne U., Linser R., Heine A., Klebe G. A False-Positive Screening Hit in Fragment-Based Lead Discovery: Watch out for the Red Herring, Angew. Chem. Int. Ed., 2017, 7, 1908–1913. Highlighted in science blog “Practical Fragments”

Cramer J., Klebe G. An Allyl Protection and Improved Purification Strategy Enables the Synthesis of Functionalized Phosphonamidate Peptides, Synthesis, 2017, 49, 1857–1866.

Cramer J., Krimmer S. G., Fridh V., Wulsdorf T., Karlsson R., Heine A., Klebe G. Elucidating the Origin of Long Residence Time Binding for Inhibitors of the Metalloprotease Thermolysin, ACS Chem. Biol., 2017, 12, 225–233.

Krimmer S. G.,+ Cramer J.,+ Betz M., Fridh V., Karlsson R., Heine A., Klebe G. Rational Design of Thermodynamic and Kinetic Binding Profiles by Optimizing Surface Water Networks Coating Protein Bound Ligands, J. Med. Chem., 2016, 59, 10530–10548. Highlighted by F1000 prime

 

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