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Publikationen des Arbeitskreises Breitkreutz

  • M. Kokott, J. Breitkreutz, R. Wiedey
    The interplay of poorly soluble drug substances released from amorphous solid dispersions.
    Int. J. Pharm. X  7: 100243 (2024)

  • R. Chamberlain, J. Breitkreutz, B. Fischer
    Drug content determination of low-dosed hot-melt extruded filaments using Raman spectroscopy.
    Pharm. Dev. Technol. 29: 258-264 (2024)

  • V. Lura, S. Klinken, J. Breitkreutz
    A systematic investigation of external lubrication of mini-tablets on a rotary tablet press with focus on tensile strength.
    Eur. J. Pharm. Biopharm. 198: 114236 (2024)

  • J. Kutzsche, G. Guzman, A. Willuweit, O. Kletke, E. Wollert, I. Gering, D. Jürgens, J. Breitkreutz, H. Stark, A. Beck-Sickinger, N. Klöcker, P. Hidalgo, D. Willbold
    An orally available N-type calcium channel inhibitor for the treatment of neuropathic pain.
    Br. J. Pharmacol. 1-23 (2024)

  • J. Thissen, M.D. Klaßen, P. Constantinidis, M.C. Hacker, J. Breitkreutz, T. Teutenberg, B. Fischer
    Online coupling of size exclusion chromatography to capillary enhanced Raman spectroscopy for the analysis of proteins and biopharmaceutical drug products.
    Anal. Chem. 95: 17868–17877 (2023)
  • V. Lura, S. Klinken, J. Breitkreutz
    Challenges in the transfer and scale-up of mini-tableting: Case study with losartan potassium.
    Eur. J. Pharm. Biopharm. 192: 161-173 (2023)
  • V. Klingmann, M. Hinder, T.H. Langenickel, F. Chen, Y. Khder, J. Breitkreutz, H.M. Bosse
    Acceptability of multiple coated mini-tablets in comparison to syrup in infants and toddlers: a randomised controlled study.
    Arch. Dis. Child. 108: 730-735 (2023)
  • L.C. Lammerding, J. Breitkreutz
    Technical evaluation of precisely manufacturing customized microneedle array patches via inkjet drug printing.
    Int. J. Pharm. 642: 123173 (2023)
  • S. Stegemann, V. Klingmann; S. Reidemeister, J. Breitkreutz
    Patient-centric drug product development acceptability across patient populations - Science and evidence.
    Eur. J. Pharm. Biopharm. 188: 1-5 (2023)
  • L. Hoffmann, J. Breitkreutz, J. Quodbach
    Investigation of the degradation and in-situ amorphization of the chiral drug escitalopram oxalate during Fused Deposition Modeling (FDM) 3D printing.
    Eur. J. Pharm. Sci. 185: 106423 (2023)
  • J. Niessen, A. López Mármol, R. Ismail, J.T. Schiele, K. Rau, A. Wahl, K. Sauer, O. Heinzerling, J. Breitkreutz, M. Koziolek
    Application of biorelevant in vitro assays for the assessment and optimization of ASD-based formulations for pediatric patients
    Eur. J. Pharm. Biopharm. 185: 13-27 (2023)
  • M. Kokott, S. Klinken, J. Breitkreutz, R. Wiedey
    Downstream processing of amorphous solid dispersions into orodispersible tablets
    Int. J. Pharm. 631: 122493 (2023)
  • M. Fligge, I. Letofsky-Papst, M. Bäumers, A. Zimmer, J. Breitkreutz
    Personalized dermal patches – inkjet printing of nanosuspensions for individualized treatment of skin diseases
    Int. J. Pharm. 630: 122382 (2023)
  • L. Hoffmann, J. Breitkreutz, J. Quodbach
    Fused Deposition Modeling (FDM) 3D printing of the thermos-sensitive peptidomimetic drug enalapril maleate
    Pharmaceutics 14: 2411 (2022)
  • J. Kuck, J. Breitkreutz
    Impact of lubrication on key properties of orodispersible minitablets in comparison to conventionally sized orodispersible tablets
    Eur. J. Pharm. Biopharm. 180: 71-80 (2022)
  • M. Hermeling, C. Nüboldt, R. Heumann, W. Hoheisel, J. Breitkreutz
    Nano-Dry-Melting: A novel technology for manufacturing of pharmaceutical amorphous solid dispersions
    Pharmaceutics 14: 2145 (2022)
  • L. Hoffmann, J. Breitkreutz, J. Quodbach
    Hot-melt extrusion of the thermo-sensitive peptidomimetic drug enalapril maleate
    Pharmaceutics 14: 2091 (2022)
  • B. Sarker, M. Fligge, T. Knaab, J. Breitkreutz
    Implementation of a new electronic liquid dispensing system for individualized compounding of hard capsules
    Pharmaceutics, 14: 1580 (2022)
  • J. Rahman-Yildir, R. Wiedey, J. Breitkreutz
    Comparative dissolution studies of 3D-printed inserts in a novel biopharmaceutical bladder model
    Int. J. Pharm. 624: 121984 (2022)
  • J. Rahman-Yildir, B. Fischer, J. Breitkreutz
    Development and optimization of sustained-release drug-loaded intravesical inserts via semi-solid micro-extrusion 3D printing for bladder targeting
    Int. J. Pharm. 622: 121849 (2022)
  • S. Läer, W. Cawello, B.B. Burckhardt, L. Ablonczy, M. Bajcetic, J.M.P.J. Breur,
    M. Dalinghaus, C. Male, S.N. de Wildt, J. Breitkreutz, M. Faisal, A. Keatley-Clarke,
    I. Klingmann, F.B. Lagler
    Enalapril and enalaprilat pharmacokinetics in children with heart failure due to dilated cardiomyopathy and congestive heart failure after administration of an orodispersible enalapril minitablet (LENA-studies)
    Pharmaceutics 14: 1163 (2022)
  • A. Lura, J. Breitkreutz
    Development and production of mini-tablets: Impact of the tableting tooling systems
    J. Drug Deliv. Sci. Technol. 72: 103357 (2022)
  • H. Windolf, R. Chamberlain, J. Breitkreutz, J. Quodbach
    3D printed mini-floating-polypill for Parkinson’s disease: Combination of levodopa, benserazide, and pramipexole in various dosing for personalized therapy
    Pharmaceutics 14: 931 (2022)
  • J. Quodbach, M. Bogdahn, J. Breitkreutz, R. Chamberlain, K. Eggenreich, A.G. Elia,
    N. Gottschalk, G. Gunkel-Grabole, L. Hoffmann, D. Kapote, T. Kipping, S. Klinken,
    F. Loose, T. Marquetant, H. Windolf, S. Geißler, T. Spitz
    Quality of FDM 3D printed medicines for pediatrics – Considerations for formulation development, filament extrusion, printing process and printer design
    Therapeutic Innovation & Regulatory Science 56: 910-928 (2022)
  • R. Chamberlain, H. Windolf, B.B. Burckhardt, J. Breitkreutz, B. Fischer
    Embedding a sensitive liquid-core waiveguide UV detector coupled to HPLC for analysis of low-dosed pramipexole during drug dissolution
    Pharmaceutics 14: 639 (2022)
  • V. Elezaj, A. Lura, L. Canha, J. Breitkreutz
    Pharmaceutical development of film-coated mini-tablets with Losartan Potassium for Epidermolysis Bullosa
    Pharmaceutics 14: 570 (2022)
  • A. Göbel, J. Breitkreutz
    Concept of orodispersible or mucoadhesive “Tandem films” and their pharmaceutical realization
    Pharmaceutics 14: 264 (2022)
  • R. Chamberlain, H. Windolf, J. Quodbach, S. Geissler, J. Breitkreutz
    Precise micro-dosing of pramiprexole filaments produced via hot-melt extrusion applying various feeding methods
    Pharmaceutics 14: 216 (2022)
  • M. Kern, T. Riedel, J. Breitkreutz
    Investigating key properties of model excipients and binary powder blends using ultrasonic in-die measurements on a compaction simulator
    Int. J. Pharm. 613: 121381 (2022)
  • R. Chamberlain, H. Windolf, J. Breitkreutz
    Innovative und etablierte Arzneizubereitungen für die Therapie des idiopathischen Parkinson-Syndroms
    Pharmakon 10: 216-226 (2022)
  • R. Wiedey, M. Kokott, J. Breitkreutz
    Orodispersible tablets for pediatric drug delivery: current challenges and
    recent advances
    Exp. Opin. Drug Deliv. 18: 1873-1890 (2021)

  • M. Müller, F. Platten, M. Dulle, B. Fischer, W. Hoheisel, P. Serno, S. Egelhaaf, J. Breitkreutz
    Precipitation from amorphous solid dispersions within biorelevant dissolution testing: The polymorphism of regorafenib
    Int. J. Pharm. 603: 120716 (2021)

  • A. Lura, V. Elezaj, M. Kokott, B. Fischer, J. Breitkreutz
    Transfer and scale-up of the manufacturing of orodispersible mini-tablets from a compaction simulator to an industrial rotary tablet press
    Int. J. Pharm. 602: 120636 (2021)

  • J.F. Alopaeus, A. Göbel, J. Breitkreutz, S.-A. Sande, I. Tho
    Investigation of hydroxypropyl-β-cyclodextrin inclusion complexation of two poorly soluble model drugs and taste-sensation - Effect of electrolytes, freeze-drying and incorporation into oral film formulations
    J. Drug Deliv. Sci. Techn. 61: 102245 (2021)

  • O. Kiefer, B. Fischer, J. Breitkreutz
    Fundamental investigations into metoprolol tartrate deposition on orodispersible films by inkjet printing for individualized drug dosing
    Pharmaceutics 13: 247 (2021)

  • M. Inoue, O. Kiefer, B. Fischer, J. Breitkreutz
    Raman monitoring of semi-continuously manufactured orodispersible films for individualized dosing
    J. Drug Deliv. Sci. Techn. 61: 102224 (2021)

  • D. Kottke, B.B. Burckhardt, J. Breitkreutz, B. Fischer
    Enhanced sensitivity by a validated HPLC-coupled liquid-core waveguide fluorescence detector - A promising alternative between conventional fluorescence and mass spectrometric detection
    Talanta 226: 122145 (2021)


  • A. Lura, G. Tardy, P. Kleinebudde, J. Breitkreutz
    Tabletting of mini-tablets in comparison with conventionally sized tablets: Tabletting properties and tablet shapes
    Int. J. Pharm. X 2:100061 (2020)
  • I. El Aita, J. Rahman, J. Breitkreutz, J. Quodbach
    3D-Printing with precise layer-wise dose adjustments for paediatric use via pressure-assisted microsyringe printing
    Eur. J. Pharm. Biopharm. 157: 59-65 (2020)
  • D. Kottke, A. Lura, D.J. Lunter, J. Breitkreutz
    Manufacturing and characterisation of a novel composite dosage form for buccal drug administration
    Int. J. Pharm. 589: 119839 (2020)
  • O. Kiefer, J. Breitkreutz
    Comparative investigations on key factors and print head designs for pharmaceutical inkjet printing
    Int. J. Pharm. 586: 119561 (2020)
  • V. Klingmann, C.E. Pohly, T. Meissner, E. Mayatepek, A. Möltner, K. Flunkert, J. Breitkreutz, H.M. Bosse
    Acceptability of an orodispersible film compared to syrup in neonates and infants:  A randomized clinical trial
    Eur. J. Pharm. Biopharm. 151: 239-245 (2020)
  • D. Kottke, H. Majid, J. Breitkreutz, B.B. Burckhardt
    Development and evaluation of mucoadhesive buccal dosage forms of  lidocaine hydrochloride by ex-vivo permeation studies
    Int. J. Pharm. 581: 119293 (2020)
  • M. Ali, J. Tins, B.B. Burckhardt on behalf of LENA consortium
    Correction to: Fit-for-purpose quality control system in continuous bioanalysis during long-term pediatric studies
    AAPS J. 22: 37 (2020)
  • I. El Aita, J. Breitkreutz, J. Quodbach
    Investigation of semi-solid formulations for 3D printing of drugs after prolonged storage to mimic real-life applications
    Eur. J. Pharm. Sci. 146: 105266 (2020)
  • J.C. Visser, L. Wibier, O. Kiefer, M. Orlu, J. Breitkreutz, H.J. Woerdenbag, K. Taxis
    A paediatrics utilization study in the Netherlands to identify active pharmaceuticals ingredients suitable for inkjet printing on orodispersible films
    Pharmaceutics 12: 164 (2020)
  • Van Hecken, B.B. Burckhardt, F. Khalil, J. de Hoon, I. Klingmann, M. Herbots, S. Laeer,  F.B. Lagler, J. Breitkreutz
    Relative bioavailability of enalapril administered as orodispersible minitablets in healthy adults
    Clin. Pharmacol. Drug Devel. 9: 203-213 (2020)


  • Lura, O. Luhn, J. Suarez Gonzales, J. Breitkreutz
    New orodispersible mini-tablets for paediatric use – A comparison of isomalt with a mannitol based co-processed excipient
    Int. J. Pharm. 572: 118804 (2019)
  • Y. Tian, M. Orlu, H.J. Woerdenbag, M. Scarpa, O. Kiefer, D. Kottke, E. Sjöholm, H. Öblom, N. Sandler, W.L.J. Hinrichs, H.W. Frijlink, J. Breitkreutz, J.C. Visser
    Oromucosal films: from patient centricity to production by printing techniques
    Exp. Opin. Drug Deliv. 16: 981-993 (2019)
  • M. Faisal, W. Cawello, B.B. Burckhardt, J. de Hoon, S. Laer, A. van Hecken, M. Herbort, J. Breitkreutz, W. Wiedey, I. Klingmann, L. Spatenkova, F. Lagler, A. Moder, F. Khalil
    Simultaneous semi-mechanistic population pharmacokinetic modeling analysis of enalapril and enalaprilat serum and urine concentrations from child appropriate orodispersible minitablets
    Frontiers in Paediatrics 7: 281 (2019)
  • M. Faisal, W. Cawello, B.B. Burckhardt, S. Laer, J. de Hoon, A. van Hecken, M. Herbort, J. Breitkreutz, W. Wiedey, I. Klingmann, L. Spatenkova, F. Lagler, A. Moder, F. Khalil
    Model-dependent pharmacokinetic analysis of enalapril administered to healthy adult volunteers using orodispersible minitablets for use in pediatrics
    Drug Design, Development and Therapy 13: 481-490 (2019)
  • M. Bajcetic, S.N. de Wildt, M. Dalinghaus, J. Breitkreutz, I. Klingmann, F.B. Lagler, A. Keatley-Clarke, J.M.P.J. Breur, C. Male, I. Jovanovic, A. Szatmári, L. Ablonczy, B.B. Burckhardt, W. Cawello, K. Kleine, E. Obercanin, L. Spatenkova, V. Swoboda, M. van der Meulen, P. Wagner, J. Walsh, S. Läer
    Orodispersible minitablets of enalapril for use in children with heart failure (LENA): Rationale and protocol for a multicentre pharmacokinetic bridging study and follow-up safety study,
    Contemporary Clinical Trials Communication 15: 100393 (2019)
  • S. Niese, J. Breitkreutz, J. Quodbach                                                                     
    Development of a dosing device for individualized dosing of orodispersible warfarin films
    Int. J. Pharm. 561: 314-323 (2019)
  • I. Speer, M. Preis, J. Breitkreutz
    Dissolution testing of oral film preparations: experimental comparison of compendial and non-compendial methods
    Int. J. Pharm. 561: 124-134 (2019)
  • I. Speer, M. Preis, J. Breitkreutz
    Novel dissolution method for oral film preparations with modified release properties
    AAPS Pharm Sci. Tech. 20(1): 7 (2019)
  • J. Peters, W. Taute, C. Döscher, M. Höft, R. Knöchel, J. Breitkreutz
    Moisture monitoring in fluid-bed granulation by multi-resonance microwave sensor: Applicability on crystal-water containing Donepezil granules
    AAPS Pharm Sci. Tech. 20(1): 6 (2019)
  • I. ElAita, J. Quodbach, J. Breitkreutz
    On-demand manufacturing of immediate release levetiracetam tablets using pressure-assisted microsyringe printing
    Eur. J. Pharm. Biopharm. 134: 29-36 (2019)
  • I. Speer, V. Lenhart, M. Preis, J. Breitkreutz
    Prolonged drug release from orodispersible films by incorporation of diclofenac-loaded micropellets Int. J. Pharm. 554: 149-160 (2019)


  • Y. Thabet, V. Klingmann, J. Breitkreutz
    Drug formulations: Standards and novel strategies for drug administration in pediatrics
    J. Clin. Pharmacol. 58: S26-S35 (2018)
  • V. Klingmann, H. Linderskamp, T. Meissner, E. Mayatepek, A. Moeltner, J. Breitkreutz, H.M. Bosse
    Acceptability of multiple uncoated mini-tablets in infants and toddlers: a randomized controlled trial
    J. Pediatr. 201: 202-207 (2018)
  • I. Speer, D. Steiner, Y. Thabet, J. Breitkreutz, A. Kwade
    Comparative study on disintegration methods for oral film preparations
    Eur. J. Pharm. Biopharm. 132: 50-61 (2018)
  • Y. Thabet, R. Sibanc, J. Breitkreutz
    Printing pharmaceuticals by inkjet technology: Proof of concept for stand-alone and continuous in-line printing on orodispersible films
    J. Manuf. Process. 35: 205-2015 (2018)
  • F.P. Fernandes, A.C. Fortes, S.G. Fonseca, J. Breitkreutz, H.G. Ferraz
    Manufacture and characterization of mucoadhesive buccal films based on pectin and gellan gum containing triamcinolone acetonide
    Int. J. Polym. Sci., Article ID 2403802 (2018)
  • I. Speer, M. Preis, J. Breitkreutz
    Prolonged drug release properties for orodispersible films by combining hot-melt extrusion and solvent casting methods
    Eur. J. Pharm. Biopharm. 129: 66-73 (2018)
  • Y. Thabet, D. Lunter, J. Breitkreutz
    Continuous ink-jet printing of enalapril maleate onto orodispersible film formulations
    Int. J. Pharm. 546: 180-187 (2018)
  • Y. Thabet, D. Lunter, J. Breitkreutz
    Continuous manufacturing and analytical characterization of fixed-dose, multilayer orodispersible films
    Eur. J. Pharm. Sci. 117: 236–244 (2018)
  • J. Peters, W. Taute, C. Döscher, R. Meier, M. Höft, R. Knöchel, J. Breitkreutz
    From laboratory- to pilot-scale: moisture monitoring in fluidized bed granulation by a novel microwave sensor using multivariate calibration approaches
    Drug Dev. Ind. Pharm. 44: 961-968 (2018)
  • Y. Thabet, J. Walsh, J. Breitkreutz
    Flexible and precise dosing of enalapril maleate for all paediatric age groups utilizing orodispersible minitablets
    Int. J. Pharm. 541: 136-142 (2018)
  • Y. Thabet, M. Slavkova, J. Breitkreutz
    10 years EU regulation of paediatric medicines – Impact on cardiovascular drug formulations
    Exp. Opin. Drug Deliv. 15: 261-270 (2018)
  • G.F. Petrovick, J. Breitkreutz
    Spheronization of solid lipid extrudates: Elucidation of spheroid formation mechanism
    Eur. J. Pharm. Biopharm. 125: 148-158 (2018)
  • J. Peters, A. Teske, W. Taute, C. Döscher, M. Höft, R. Knöchel, J. Breitkreutz
    Real-time process monitoring in a semi-continuous fluid-bed dryer – microwave resonance technology versus near-infrared spectroscopy
    Int. J. Pharm. 537: 193-201 (2018)
  • G.F. Petrovick, P. Kleinebudde, J. Breitkreutz
    Orodispersible tablets containing taste-masked solid lipid pellets with metformin hydrochloride: Influence of process parameters on tablet properties
    Eur. J. Pharm. Biopharm. 122: 137-145 (2018)
  • Y. Thabet, J. Breitkreutz
    Orodispersible films: Product transfer from lab-scale to continuous manufacturing
    Int. J. Pharm. 535: 285-292 (2018)



  • M. Münster, C. Schoch, C. Schmidt, J. Breitkreutz
    Multiparticulate system combining taste masking and immediate release properties for the aversive compound praziquantel
    Eur. J. Pharm. Sci. 109: 446-454 (2017)
  • S. Lindert, J. Breitkreutz
    Oromucosal multilayer films for tailor-made, controlled drug delivery
    Expert Opin. Drug Deliv. 14: 1265-1279 (2017)
  • M. Münster, A.H.A. Mohamed-Ahmed, L.I. Immohr, C. Schoch, C. Schmidt, C. Tuleu, J. Breitkreutz
    Comparative in vitro and in vivo taste assessment of liquid praziquantel formulations
    Int. J. Pharm. 529: 310-318 (2017)
  • J. Peters, K. Bartscher, C. Döscher, W. Taute, M. Höft, R. Knöchel, J. Breitkreutz
    In-line moisture monitoring in fluidized bed granulation using a novel multi-resonance microwave sensor
    Talanta 170: 369-376 (2017)
  • J. Peters, W. Taute, K. Bartscher, C. Döscher, M. Höft, R. Knöchel, J. Breitkreutz
    Design, development and method validation of a novel multi-resonance microwave sensor for moisture measurement
    Anal. Chim. Acta 961: 119-127 (2017)
  • M. Preis, J. Breitkreutz
    Pediatric Drug Development and Dosage Form Design
    AAPS PharmSciTech 18: 239-240 (2017)



  • V. Klingmann, Y. Thabet, J. Breitkreutz
    Arzneiformen für Kinder
    Pharmakon 4: 134-140 (2016)
  • L.H.E. Leithold, N. Jiang, J. Post, N. Niemietz, E. Schartmann, T. Ziehm, J. Kutzsche, N. J. Shah; J. Breitkreutz; K.J. Langen, A. Willuweit, D. Willbold
    Pharmacokinetic properties of tandem D-peptides designed for treatment of Alzheimer's disease
    Eur. J. Pharm. Sci. 89: 31-38 (2016)
  • G.F. Petrovick, J. Breitkreutz, M. Pein
    Taste-masking properties of solid lipid based micropellets obtained by cold extrusion-spheronization
    Int. J. Pharm. 506: 361-370 (2016)
  • R. Krampe, J.C. Visser, H.W. Frijlink, J. Breitkreutz, H.J. Woerdenbag, M. Preis
    Oromucosal film preparations: points to consider for patient centricity and manufacturing processes
    Expert Opin. Drug Deliv. 13:493-506 (2016)
  • L.H.E. Leithold, N. Jiang, J. Post, T. Ziehm, E. Schartmann, J. Kutzsche, N.J. Shah, J. Breitkreutz, K.-J. Langen, A. Willuweit, D. Willbold
    Pharmacokinetic properties of a novel D-peptide developed to be therapeutically active against toxic ß-amyloid oligomers
    Pharm. Res. 33: 328-336 (2016)
  • A. de Beaumais Tiphaine, L.L. Hjalgrim, J. Nersting, J. Breitkreutz, B. Nelken, M. Schrappe, M. Stanulla, C. Thomas, Y. Bertrand, G. Leverger, A. Baruchel, K. Schmiegelow, E. Jacqz-Aigrain
    Evaluation of a pediatric liquid formulation to improve 6-mercaptopurine therapy in children
    Eur. J. Pharm. Sci. 83: 1-7 (2016)
  • E.J. Laukamp, K. Knop, M. Thommes, J. Breitkreutz
    Micropellet-loaded rods with dose-independent sustained release properties for individual dosing via the Solid Dosage Pen
    Int. J. Pharm., 499: 271-279 (2016)
  • R. Krampe, D. Sieber, M. Pein, J. Breitkreutz
    A new biorelevant dissolution method for orodispersible films
    Eur. J. Pharm. Biopharm. 98: 20-25 (2016)


  • V. Klingmann, A. Seitz, T. Meissner, J. Breitkreutz, A. Moeltner, H.M. Bosse
    Acceptability of uncoated minitablets in neonates – a randomized controlled trial
    J. Pediatr. 167: 893-896 (2015)
  • M. Preis, J. Breitkreutz, N. Sandler
    Perspective: Concepts of printing technologies for oral film formulations
    Int. J. Pharm. 494: 578-84 (2015)
  • N. Jiang, L.H.E. Leithold, J. Post, T. Ziehm, J. Mauler, K.-J. Langen, J. Breitkreutz, D. Willbold, A. Willuweit
    Preclinical pharmacokinetic studies of the tritium labelled D-enantiomeric peptide D3 developed for the treatment of Alzheimer´s disease
    PLoS One 10(6): e0128553 (2015)
  • M. Rohrschneider, S. Bhagwat, R. Krampe, V. Michler, J. Breitkreutz, G. Hochhaus
    Evaluation of the Transwell® system for characterization of dissolution behavior of inhalation drugs: Effects of membrane and surfactant
    Mol. Pharm. 12: 2618-24 (2015)
  • J. Walsh, M.C. Math, J. Breitkreutz, T. Zerback, H. Wachtel
    Devices for oral and respiratory paediatric medicines: What do healthcare professionals think?
    Int. J. Pharm. 492: 304-315 (2015)
  • M. Preis, L. Grother, P. Axe, J. Breitkreutz
    In-vitro and in-vivo evaluation of taste-masked cetirizine hydrochloride formulated in oral lyophilisates
    Int. J. Pharm. 491: 8-16 (2015)
  • M. Slavkova, J. Breitkreutz
    Orodispersible drug formulations for children and elderly
    Eur. J. Pharm. Sci. 75: 2-9 (2015)
  • M. Guhmann, M. Preis, F. Gerber. N. Pöllinger, J. Breitkreutz, W. Weitschies
    Design, development and in vitro evaluation of diclofenac taste-masked orodispersible tablet formulations
    Drug Dev. Ind. Pharm. 41: 540-551 (2015)
  • J.C. Visser, W.M.C. Dohmen, W.L.J. Hinrichs, J. Breitkreutz, H.W. Frijlink, H.J. Woerdenbag
    Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films?
    Int. J. Pharm. 485: 70-76 (2015)
  • G. Petrovick, M. Pein, M. Thommes, J. Breitkreutz
    Spheronization of solid small lipid extrudates: an innovative approach in process control
    Eur. J. Pharm. Biopharm. 92: 15-21 (2015)
  • B. Coulibaly, M. Pritsch, M. Bountogo, P.E. Meissner, E. Nebié, C. Klose, M. Kieser, N. Berens-Riha, A. Wieser, S.B. Sirima, J. Breitkreutz, R.H. Schirmer, A. Sié, F.P. Mockenhaupt, C. Drakeley, T. Bousema, O. Müller
    Efficacy and safety of triple combination therapy with artesunate-amodiaquine- methylene blue for falciparum malaria in children: a randomized controlled trial in Burkina Faso
    J. Infect. Dis. 211: 689-697 (2015)
  • E M. Laukamp, A.K. Vynckier, J. Voorspels, M. Thommes, J. Breitkreutz
    Development of sustained and dual drug release co-extrusion formulations for individual dosing
    Eur. J. Pharm. Biopharm. 89: 357-364 (2015)
  • C.M. Wagner, M. Pein, J. Breitkreutz
    Roll compaction of granulated mannitol grades and the unprocessed crystalline delta-polymorph
    Powder Technol. 270: 470-475 (2015)
  • J.C. Visser, H.J. Woerdenbag, S. Crediet, E. Gerrits, M.A. Lesschen, W.L.J. Hinrichs, J. Breitkreutz, H.W. Frijlink
    Orodispersible films in individualized pharmacotherapy: the development of a formulation for pharmacy preparations
    Int. J. Pharm. 478: 155-163 (2015)


  • C. Eckert, M. Pein, J. Breitkreutz
    Lean production of taste masked lipidic sodium benzoate formulations
    Eur. J. Pharm. Biopharm. 88: 455-461 (2014)
  • E M. Laukamp, M. Thommes, J. Breitkreutz
    Hot-Melt Extruded Drug-Loaded Rods: Evaluation of the Mechanical Properties for Individual Dosing via the Solid Dosage Pen
    Int. J. Pharm. 275: 344-350 (2014)
  • M. Preis, D. Gronkowsky, D. Grytzan, J. Breitkreutz
    Comparative study on novel test systems to determine disintegration time of orodispersible films
    J. Pharm. Pharmacol. 66: 1102-1111 (2014)
  • M. Preis, O. Häusler, J. Breitkreutz
    Electronic tongues in preformulation studies - Application of electronic tongues in preformulations studies to evaluate taste-masking capacities of maltodextrins
    Pharm. Ind. 76: 957-962 (2014)
  • J. Walsh, A. Cram, C. Tuleu, G. Winzenburg, R. Turner, K. Woertz, J. Breitkreutz
    Playing hide and seek with poorly tasting paediatric medicines: do not forget the excipients
    Adv. Drug Deliv. Rev. 73: 14-33 (2014)
  • M. Preis, C. Woertz, K. Schneider. J. Kukawka, J. Breitkreutz
    Bilayer oromucosal film preparations for local administration of lidocaine hydrochloride
    Eur. J. Pharm. Biopharm. 86: 552-561 (2014)
  • S. Lindert, A. Below, J. Breitkreutz
    Performance of dry powder inhalers with single dosed capsules in preschool children and adults using improved upper airway models
    Pharmaceutics 6: 36-51 (2014)
  • M. Preis, C. Eckert, O. Häusler, J. Breitkreutz
    A comparative study on solubilizing and taste-masking capacities of hydroxypropyl-ß-cyclodextrin and maltodextrins with high amylose content
    Sensors & Actuators B 193: 442-450 (2014)
  • M. Preis, K. Knop, J. Breitkreutz
    Mechanical strength test for orodispersible and buccal films
    Int. J. Pharm. 461: 22-29 (2014)




  • S. Just, F. Sievert, M. Thommes, J. Breitkreutz
    Improved group contribution parameter set for the application of solubility parameters to melt extrusion
    Eur. J. Pharm. Biopharm. 85: 1191-1199 (2013)
  • N. Genina, E.M. Janßen, A. Breitenbach, J. Breitkreutz, N. Sandler
    Evaluation of different substrates for inkjet-printing of rasagiline mesylate substrates
    Eur. J. Pharm. Biopharm. 85: 1075-1083 (2013)
  • C. Woertz, M. Preis, J. Breitkreutz, P. Kleinebudde
    Assessment of test methods evaluating mucoadhesive polymers and dosage forms: an overview
    Eur. J. Pharm. Biopharm. 85: 843-853 (2013)
  • V. Klingmann, N. Spomer, C. Lerch, I. Stoltenberg, C. Frömke, H.M. Bosse, J. Breitkreutz, T. Meissner
    Favourable acceptance of mini-tablets compared with syrup: a randomised controlled trial in infants and preschool children
    J. Pediatr. 163:1728-1732 (2013)
  • B. Kollar, J. Breitkreutz, W. Wiedey, K. Bartscher, C. Döscher
    Innovative Mikrowellenresonanz-Sensoren für die Messung in Wirbelschichtgeräten
    TechnoPharm 3: 317-321 (2013)
  • A. Zajicek, M.J. Fossler, J.S. Barrett, J.H. Worthington, R. Ternik, G. Charkoftaki, S. Lum, J. Breitkreutz, M. Baltezor, P. Macheras, M. Khan, S. Agharkar, D.D. MacLaren
    A report from the Pediatric Formulations Task Force: Perspectives on the state of child-friendly oral dosage forms
    AAPS J. 15: 1072-1081 (2013)
  • M. Haupt, M. Thommes, A. Heidenreich, J. Breitkreutz
    Lipid-based intravesical drug delivery systems with controlled release of trospium chloride for the urinary bladder
    J. Control. Rel. 170: 161-166 (2013)
  • M. Preis, C. Wörtz, P. Kleinebudde, J. Breitkreutz
    Characterization of oromucosal film preparations
    Exp. Opin. Drug Deliv. 10: 1303-1317 (2013)
  • C.M. Wagner, M. Pein, J. Breitkreutz
    Roll compaction of mannitol: Compactability study of crystalline and spray-dried grades
    Int. J. Pharm. 453: 416-422 (2013)
  • M. Pein, C. Eckert, M. Preis, J. Breitkreutz
    New protocol for Astree electronic tongue enabling full performance qualification according to ICH Q2 using caffeine citrate as model substance
    J. Pharm. Biomed. Anal. 83: 157-163 (2013)
  • M. Guhmann, M. Thommes, F. Gerber, N. Pöllinger, S. Klein, J. Breitkreutz, W. Weitschies
    Design of biorelevant test setups for the prediction of diclofenac in vivo features after oral administration
    Pharm. Res. 30: 1483-1501 (2013)
  • C. Eckert, M. Pein, J. Reimann, J. Breitkreutz
    Taste evaluation of multicomponent mixtures using a human taste panel, electronic taste sensing systems and HPLC
    Sensors and Actuators B 182: 294-299 (2013)
  • A. Below, D. Bickmann, J. Breitkreutz
    Assessing the performance of two dry powder inhalers in preschool children using an idealized upper airway model
    Int. J. Pharm. 444: 169-174 (2013)
  • E.M. Janßen, R. Schliephacke, A. Breitenbach, J. Breitkreutz
    Drug-printing by Flexography – a new manufacturing process for orodispersible films
    Int. J. Pharm. 441: 818-825 (2013)




  • N. Guffon, Y. Kibleur, W. Coppalu, C. Tissen, J. Breitkreutz
    Studies of a new formulation of sodium phenylbutyrate
    Arch. Dis. Child. 97: 1081-1085 (2012)
  • K. Wening, E.J. Laukamp, M. Thommes, J. Breitkreutz
    Individual oral therapy with immediate release and  effervescent formulations delivered by the Solid Dosage Pen
    J. Pers. Med. 2: 217-231 (2012)
  • M. Preis, M. Pein, J. Breitkreutz
    Development of a taste-masked orodispersible film containing dimenhydrinate
    Pharmaceutics 4: 551-562 (2012)
  • M. Guhmann, M. Preis, F. Gerber, N. Pöllinger, J. Breitkreutz, W. Weitschies
    Development of oral taste masked diclofenac formulations using a taste sensing system
    Int. J. Pharm. 438: 81-90 (2012)
  • C. Kindermann, K. Matthée, F. Sievert, J. Breitkreutz
    Electrolyte-stimulated biphasic dissolution profile and stability enhancement for tablets containing drug-polyelectrolyte complexes
    Pharm. Res. 29: 2710-2721 (2012)
  • T. Ernest, J. Craig, A. Nunn, S. Salunke, C. Tuleu, J. Breitkreutz, R. Alex, J. Hempenstall
    Preparation of medicines for children – a hierachy of classification
    Int. J. Pharm. 435: 124-130 (2012)
  • S. Stegemann, M. Gogol, J. Breitkreutz
    Swallowing dysfunction and dysphagia is an unrecognized challenge for oral drug therapy
    Int. J. Pharm. 430: 197-206 (2012)
  • J. Vaassen, K. Bartscher, J. Breitkreutz
    Taste masked lipid pellets with enhanced release of hydrophobic active ingredient
    Int. J. Pharm. 429: 99-103 (2012)
  • N. Spomer, V. Klingmann, I. Stoltenberg, C. Lerch, T. Meissner, J. Breitkreutz
    Acceptance of uncoated mini-tablets in young children – Results from a prospective exploratory cross-over study
    Arch. Dis. Child. 97: 283-286 (2012)



  • K. Woertz, C. Tissen, P. Kleinebudde, J. Breitkreutz
    Development of a taste masked generic ibuprofen suspension - Top down approach guided by electronic tongue measurements
    J. Pharm. Sci. 100: 4460-4470 (2011)
  • K. Woertz, C. Tissen, P. Kleinebudde, J. Breitkreutz
    Taste sensing systems (electronic tongues) for pharmaceutical applications
    Int. J. Pharm. 417: 256-271 (2011)
  • C. Tissen, K. Woertz, J. Breitkreutz, P. Kleinebudde
    Development of mini-tablets with 1 mm and 2 mm diameter
    Int. J. Pharm. 416: 164-170 (2011)
  • I. Stoltenberg, J. Breitkreutz
    Orally disintegrating mini-tablets (ODMTs) - A novel solid dosage form for paediatric use
    Eur. J. Pharm. Biopharm. 78: 462-469 (2011)
  • J. Walsh, D. Bickmann, J. Breitkreutz, M. Chariot-Goulet
    Delivery devices for the administration of paediatric formulations: Overview of current practice, challenges and recent developments
    Int. J. Pharm. 415: 221-231 (2011)
  • C. Eckert, C. Lutz, J. Breitkreutz, K. Woertz
    Quality control of oral herbal products by an electronic tongue - a case study on sage lozenges
    Sensors and Actuators B 156: 204-212 (2011)
  • J. Breitkreutz, J. Boos
    Drug delivery and formulations
    in: H.W. Seyberth, A. Rane, M. Schwab (eds.): Handbook of Experimental Pharmacology, Vol. 205: Paediatric Clinical Pharmacology, S. 91-107, Springer-Verlag, Berlin Heidelberg (2011)
  • K. Woertz, C. Tissen, P. Kleinebudde, J. Breitkreutz
    A comparative study on two electronic tongues for pharmaceutical formulation development
    J. Pharm. Biomed. Anal. 55: 272-281 (2011)
  • E.M. Hoffmann, A. Breitenbach, J. Breitkreutz
    Advances in orodispersible films for drug delivery
    Exp. Opin. Drug Deliv. 8: 299-316 (2011)
  • K. Wening, J. Breitkreutz
    Oral drug delivery in personalized medicine: Unmet needs and novel approaches
    Int. J. Pharm. 404: 1-9 (2011)


  • K. Woertz, C. Tissen, P. Kleinebudde, J. Breitkreutz
    "Qualification of an electronic tongue according to ICH guideline Q2"
    J. Pharm. Biomed. Anal. 51: 497-506 (2010)
  • K. Woertz, C. Tissen, P. Kleinebudde, J. Breitkreutz
    "Rational development of taste masked oral liquids guided by an electronic tongue"
    Int. J. Pharm. 400: 114-123 (2010)
  • S. Stegemann, F. Ecker, M. Maio, P. Kraahs, J. Breitkreutz, A. Zimmer, D. Bar-Shalom, P. Hettrich
    "Geriatric drug therapy: neglecting the inevitable majority"
    Ageing Res. Rev. 9: 384-398 (2010)
  • M. Hermes, L. Barnscheid, V. Garsuch, P. Schoettler, J. Breitkreutz
    "Arzneimittelversorgung von Kindern – Ergebnisse einer Studie zur praktischen Auswirkung der EU-Verordnung 1901/2006 „Better Medicines for Children“ seit dem Inkrafttreten im Januar 2007"
    Pharm. Ind. 72: 1334-1344 (2010)
  • I. Stoltenberg, G. Winzenburg, J. Breitkreutz
    "Solid oral dosage forms for children – formulations, excipients and acceptance issues"
    J. Appl. Ther. Res. 7: 141-146 (2010)
  • K. Wening, J. Breitkreutz
    "Novel delivery device for monolithical solid oral dosage forms for personalized medicine"
    Int. J. Pharm. 395: 174-181 (2010)
  • V. Garsuch, J. Breitkreutz
    "Comparative investigations on different polymers for the manufacturing of fast-dissolving oral films"
    J. Pharm. Pharmacol. 62: 539-545 (2010)
  • K. Woertz, C. Tissen, P. Kleinebudde, J. Breitkreutz
    "Performance qualification of an electronic tongue according to ICH guideline Q2"
    J. Pharm. Biomed. Anal. 51: 497-506 (2010)
  • S. Ramusovic, S. Läer, J. Breitkreutz
    "Bosentan in der Pädiatrie"
    Pharm. Unserer Zeit 39: 454-458 (2010)
  • I. Stoltenberg, G. Winzenburg, J. Breitkreutz
    "Solid oral dosage forms for children – formulations, excipients and acceptance issues"
    Ind. Pharm. 27: 15-18 (2010)
  • J. Breitkreutz, W. Friess
    "Kindgerechte Arznieimittel mit gentechnisch hergestellten Wirkstoffen"
    Annual Biotech-Report VfA, 46 (2010)
  • I. Stoltenberg, J. Breitkreutz
    "Ludiflash®- preparation and characterization of orally disintegrating mini-tablets for pediatric use"
    ExAct 24: 7-10 (2010)
  • J. Breitkreutz, W. Frieß
    "Kindgerechte Arzneimittel mit gentechnisch hergestellten Wirkstoffen"
    In: D. Michl, A. Heinemann (eds.): Medizinische Biotechnologie in Deutschland 2010 BCG GmbH, München (2010)
  • J. Breitkreutz
    "Schnell zerfallende orale Arzneiformen"
    in K. Mäder, U. Weidenauer (eds.): Innovative Arzneiformen, Wissenschaftliche Verlagsgesellschaft, Stuttgart, ISBN-13: 978-3-8047-2455-6 (2010)
  • P. Rohdewald, G. Rücker, K.W. Glombitza, bearbeitet von J. Breitkreutz, K.W. Glombitza, G. Rücker, M.A. Hubert
    "Apothekengerechte Prüfvorschriften"
    Deutscher Apotheker Verlag, Stuttgart 13. Erg.-Lieferung (2010): ISBN 978-3-7692-5192-0



  • C. Buschmüller, W. Wiedey, C. Döscher, M. Plitzko, J. Breitkreutz
    "In-line monitoring of granule moisture and temperature throughout the entire fluidized-bed granulation process using microwave resonance technology"
    Part I: Pharm. Ind. 71: 1403-1408 (2009)
    Part II: Pharm. Ind. 71: 1614-1620 (2009)
  • V. Garsuch, J. Breitkreutz
    "Novel analytical methods for the characterization of oral wafers"
    Eur. J. Pharm. Biopharm. 73:195-201 (2009)
  • J. Krause, M. Thommes, J. Breitkreutz
    "Immediate release pellets with lipid binders obtained by solvent-free cold extrusion"
    Eur. J. Pharm. Biopharm. 71: 138-144 (2009)
  • A. Cram, J. Breitkreutz, S. Desset-Brèthes, T. Nunn, C. Tuleu
    "Challenges of developing palatable oral paediatric formulations"
    Int. J. Pharm. 365: 1-3 (2009)
  • J. Breitkreutz
    "Excipients for paediatric use"
    Bulletin Technique Gattefossé 102: 71-75 (2009)
  • J. Breitkreutz
    "Pharmazeutisch-technologische und biopharmazeutische Aspekte der Thrombozytenaggregationshemmer"
    Pharm. Unserer Zeit 38: 330-337 (2009)
  • J. Breitkreutz
    "Arzneiformen für Kinder"
    Pharm. Unserer Zeit 38: 30-37 (2009)
  • P. Rohdewald, G. Rücker, K.W. Glombitza, bearbeitet von J. Breitkreutz, K.W. Glombitza, G. Rücker, M.A. Hubert
    "Apothekengerechte Prüfvorschriften"
    Deutscher Apotheker Verlag, Stuttgart 12. Erg.-Lieferung (2009): ISBN 978-3-7692-4192-1
  • J. Breitkreutz
    "Schnell zerfallende orale Arzneiformen"
    in C. Mäder, U. Weidenauer (eds.): Innovative Arzneiformen, 3. Aufl., Wissenschaftliche Verlagsgesellschaft, Stuttgart, ISBN-13: 978-3-8047-2455-6 (2009)



  • J. Breitkreutz
    "European perspectives on pediatric formulations"
    Clin. Ther. 30: 2146-2154 (2008)
  • C. Buschmüller, W. Wiedey, C. Döscher, J. Dressler, J. Breitkreutz
    "In-line monitoring of granule moisture in fluidized bed dryers using Microwave Resonance Technology"
    Eur. J. Pharm. Biopharm. 69: 380-387 (2008)
  • J. Krause, J. Breitkreutz
    "Improving drug delivery in pediatric medicine"
    Pharm. Med. 22: 41-50 (2008)
  • J. Breitkreutz
    "Die elektronische Zunge. Geschmacksvorhersage mittels Chemosensorenarray-System"
    GIT Labor-Fachzeitschrift 3/2008, 257
  • J. Breitkreutz
    "Geschmacksmaskierung – Bittere Arzneistoffe gut kaschiert"
    Pharm. Ztg., 153: 376-383 (2008)
  • J. Breitkreutz
    "Geschmacksmaskierung und andere galenische Tricks zur Verbesserung der Compliance"
    Pharm. Ztg. 153 Suppl. 1: 6-9 (2008)
  • J. Breitkreutz, R. Eifler-Bollen, A. Kiefer
    "Fit für die Rezeptur – Ein Trainingsbuch für das Apothekenteam"
    Govi-Verlag, Eschborn; 1. Auflage (2008): ISBN-13:978-3-7741-1074-8 



  • J. Breitkreutz, J. Boos
    "Paediatric and geriatric drug delivery"
    Exp. Opin. Drug Deliv. 4: 37-45 (2007)
  • J. Breitkreutz, T. G. Gan, B. Schneider, P. Kalisch
    "Enteric-coated solid dosage forms containing sodium bicarbonate as a drug substance: an exception from the rule? "
    J. Pharm. Pharmacol. 59: 59-65 (2007)
  • J. Breitkreutz, C. Tuleu, D. Solomonidou
    "Paediatric formulations"
    In: K. Rose, J. N. van den Anker (Hrsg.): Guide to paediatric clinical research, 65-77, S. Karger AG, CH-Basel, (2007) ISBN-13: 978-3-8055-8201-8 
  • K. Grießmann, J. Breitkreutz, M. Schubert-Zsilavecz, M. Abdel Tawab
    "Dosing accuracy of measuring devices provided with antibiotic oral suspensions"
    Paed. Perinat. Drug Ther. 8: 61-70 (2007)
  • J. Breitkreutz, J. Buckham, M. Fischer, R. Pöstges, J. Boos
    "Comparative in vitro-studies on different 6-mercaptopurine formulations for the use in children"
    Paed. Perinat. Drug Ther. 8: 31-39 (2007)
  • J. Breitkreutz, U. Holzgrabe, P. Kleinebudde, K. Michel, A. Ritter, F. Stieneker"
    Wann Tabletten geteilt werden dürfen"
    Dtsch. Apoth. Ztg. 147: 2854-2855 (2007)



  • J. Breitkreutz
    "Arzneizubereitungen für Kinder"
    Pharm. Ztg. 151 Suppl.: 21-24 (2006)
  • L. Barnscheid, J. Kakkanattuparambil, H. Yildirim, J. Breitkreutz
    "Hydrochlorothiazid – Kapsel-Herstellung auf dem Prüfstand"
    Pharm. Ztg. 151: 4812-4816 (2006)
  • J. Breitkreutz
    "Rezepturarzneimittel im Krankenhaus – Erste systematische Auswertung von Verordnungsdaten"
    Management & Krankenhaus (11): 29 (2006)
  • S. Läer, K. G. Schmidt, J. Breitkreutz
    "Europäische Union zeigt Herz für Kinder"
    Cardio News 9 (7-8): 33 (2006)
  • K. Grießmann, J. Breitkreutz, P. Schoettler, M. Schubert-Zsilavecz, M. Tawab
    "Dosiergenauigkeit und sichere Anwendung von Amoxicillintrockensäften"
    päd Praktische Pädiatrie 8: 266-271 (2006)
  • M. Bonati, J. Breitkreutz, I. Choonara, K. Hoppu, E. Jacqz-Aigrain, J.-P. Langhendries, G. Pons, A. Rane, H. Seyberth, J. van den Anker
    "Paediatric clinical pharmacology in Europe"
    Paed. Perinat. Drug Ther. 7: 134-137 (2006)
  • P. Rohdewald, G. Rücker, P. Glombitza, unter Mitarbeit von J. Breitkreutz
    "Apothekengerechte Prüfvorschriften"
    11. Erg.-Lieferung Deutscher Apotheker Verlag, Stuttgart (2006; ISBN 3-7692-4191-6
  • J. Breitkreutz
    "Colestyramin Ph. Eur. 5.0"
    Kommentar zum Europäischen Arzneibuch, Wiss. Verlagsges. Stuttgart (2006);
    ISBN 3-8047-2268-7 (Akt.-lieferung), ISBN 3-8047-2269-5 (Grundwerk)
  • J. Breitkreutz
    "Kindgerechte Arzneizubereitungen"
    In: A. Labisch (Hrsg.): Jahrbuch der Heinrich-Heine-Universität Düsseldorf 2005/2006, S. 161-172
    Heinrich-Heine-Universität, Düsseldorf (2006); ISBN 3-9808514-4-3
  • J. Breitkreutz
    "Novel approaches to the route of administration"
    In E. Jacqz-Aigrain, I. Choonara (Hrsg.): Paediatric Clinical Pharmacology. 235-243,
    1. Aufl., FontisMedia S.A., CH-Lausanne and  Taylor & Francis, US-New York (2006), ISBN 0-8247-2189-6


  • K. Grießmann, J. Breitkreutz, P. Schoettler, M. Schubert-Zsilavecz, M. Abdel Tawab
    "Amoxicillintrockensäfte - Dosierungsgenauigkeit und sichere Handhabung"
    Monatsschr. Kinderheilkd. 153: 735-740 (2005) 
  • J. Breitkreutz
    "Kindgerechte Arzneiformen - Neue Produkte und Entwicklungsprojekte"
    Monatsschr. Kinderheilkd. 153: 726-734 (2005)
  • J. Breitkreutz
    "Was zeichnet kindgerechte Arzneimittel aus?"
    Der Allgemeinarzt 42-44 (2005)
  • J. Breitkreutz
    "Pharmazeutisch-technologische und biopharmazeutische Aspekte der Arzneizubereitungen mit Protonenpumpenhemmern"
    Pharm. Unserer Zeit 34: 216-223 (2005) 



  • J. Breitkreutz
    "Kindgerechte Arzneizubereitungen zur peroralen Anwendung"
    Habilitationsschrift, Universität Münster (2004)
  • R.S. Müller, J. Breitkreutz, R. Gröning
    "Interactions between aqueous Hypericum perforatum extracts and drugs: in vitro studies"
    Phytother. Res. 18: 1019-1023 (2004)
  • H. Neye, J. Breitkreutz
    "Spezielle Aspekte der Arzneimitteltherapie in Kindheit und Alter"
    Med. Monatsschr. Pharm. 27: 161-167 (2004)



  • J. Breitkreutz, F. El-Saleh, C. Kiera, P. Kleinebudde, W. Wiedey
    "Pediatric drug formulations of sodium benzoate: II. Coated granules with a lipophilic binder"
    Eur. J. Pharm. Biopharm. 56: 255-260 (2003)
  • C. Reinke, J. Breitkreutz, H. Leuenberger
    "Aluminium in drugs - risks outweigh benefits ?"
    Drug Safety (2003)
  • J. Breitkreutz, M. Bornhöft, F. Wöll, P. Kleinebudde
    "Pediatric drug formulations of sodium benzoate: I. Coated granules with a hydrophilic binder"
    Eur. J. Pharm. Biopharm. 56: 247-253 (2003)
  • R. Gröning, J. Breitkreutz, R.S. Müller
    "Physico-chemical interactions between extracts of Hypericum perforatum L. and drugs"
    Eur. J. Pharm. Biopharm. 56: 231-236 (2003)
  • B. Chankvetadze, K. Lomsadze, N. Burjanadze, J. Breitkreutz, G. Pintore, M. Chessa, K. Bergander, G. Blaschke
    "Comparative enantioseparations with native b-cyclodextrin, randomly acetylated b-cyclodextrin and heptakis-(2,3-di-O-acetyl)-b-cyclodextrin in capillary electrophoresis"
    Electrophoresis 24: 1083-1091 (2003)
  • J. Breitkreutz, T. Wessel, J. Boos
    "13. Dosage forms for oral drug administration"
    In I. Choonara, T. Nunn, G. Kearns (Hrsg.): Introduction to paediatric and perinatal drug therapy, 189-205
    1.Aufl., Nottingham University Press (2003), ISBN 1-897676-37-9



  • B. Chankvetadze, N. Burjanadze, J. Breitkreutz, K. Bergander, D. Bergenthal, O. Kataeva, R. Fröhlich, H. Luftmann, G. Blaschke
    "Mechanistic study on the opposite migration order of the enantiomers of ketamine with alpha- and beta-cyclodextrins in capillary electrophoresis"
    J. Sep. Sci. 25: 1155-1166 (2002)
  • J. Breitkreutz, J. Boos, P. Kleinebudde
    "Kindgerechte Darreichungsformen - Arzneimitteltherapie für alle"
    Pharm. Ztg. 147: 16-24 (2002)
  • R. Gröning, J. Breitkreutz, V. Baroth, R.S. Müller
    "Nanoparticles in plant extracts - influence of drugs on the formation of nanoparticles and precipitates in black tea infusions"
    Eur. J. Pharm. Sci. 15: 149-155 (2002)
  • J. Breitkreutz
    "Kindgerechte Darreichungsformen"
    In Health Care NRW e.V. (Ed.): Arzneimittel für Kinder und Jugendliche - aktueller Stand und Entwicklungsmöglichkeiten 12-13 (2002)



  • R. Gröning, J. Breitkreutz, V. Baroth, R.S. Müller
    "Nanoparticles in plant extracts - factors which influence the formation of nanoparticles in black tea infusions"
    Pharmazie 56: 790-792 (2001)
  • W. Weitschies, R. Grützmann, V. Hartmann, J. Breitkreutz
    "Determination of the disintegration behaviour of magnetically marked tablets"
    Eur. J. Pharm. Biopharm. 52: 221-226 (2001)
  • B. Chankvetadze, I. Kartozia, J. Breitkreutz, Y. Okamoto, G. Blaschke
    "Effect of organic solvent, electrolyte salt and a loading of cellulose tris(3,5-dichlorophenylcarbamate) on silica gel on enantioseparation characteristics in capillary electrochromatography"
    Electrophoresis 22: 3327-3334 (2001)
  • B. Chankvetadze, K. Lomsadze, D. Bergenthal, J. Breitkreutz, K. Bergander, G. Blaschke
    "Mechanistic study on the opposite migration order of clenbuterol enantiomers in capillary electrophoresis with beta-CD and single isomer heptakis-(2,3-diacetyl-6-sulfo)-beta-cyclodextrin"
    Electrophoresis 22: 3178-3184 (2001)
  • T. Wessel, J. Breitkreutz, E. Ahlke, G. Hempel, J. Boos
    "Probleme in der Dauertherapie mit Mercaptopurin-Tabletten"
    Krankenhauspharmazie 22: 325-329 (2001)
  • W. Weitschies, M. Karaus, D. Cordini, L. Trahms, J. Breitkreutz, W. Semmler
    "Magnetic marker monitoring of disintegrating capsules"
    Eur. J. Pharm. Sci. 13: 411-416 (2001)
  • B. Chankvetadze, I. Kartozia, J. Breitkreutz, M. Girod, M. Knobloch, Y. Okamoto, G. Blaschke
    "Comparative capillary chromatographic and capillary electrochromatographic enantioseparations using cellulose tris(3,5-dichlorophenylcarbamate) as a chiral stationary phase"
    J. Sep. Sci. 24: 251-257 (2001)
  • J. Breitkreutz, G. Heun
    "Grundlagen der Physikalischen Chemie für Pharmazeuten"
    1st edition, IPT-Verlag Münster (2001), ISBN 3-9803753-5-8



  • G. Yener, Y. Topaloglu, J. Breitkreutz
    "Enhancement of dissolution of tiaprofenic acid via inclusion with skimmed milk"
    S.T.P. Pharma Sci. 10: 401-404 (2000)
  • J. Breitkreutz
    "Leakage of Enteric (Eudragit L)-Coated Dosage Forms in Simulated Gastric Juice in the Presence of Poly(ethylene glycol)"
    J. Control. Release 67: 79-88 (2000)
  • B. Chankvetadze, G. Pintore, N. Burjanadze, D. Bergenthal, K. Bergander, J. Breitkreutz, C. Mühlenbrock, G. Blaschke
    "Mechanistic study of opposite migration order of dimethindene enantiomers in capillary electrophoresis in the presence of native beta-CD and  heptakis-(2,3,6-tri-O-methyl)-beta-CD"
    J. Chromatogr. A 875: 455-469 (2000)
  • B. Chankvetadze, N. Burjanadze, G. Pintore, D. Bergenthal, K. Bergander, C. Mühlenbrock, J. Breitkreutz, G. Blaschke
    "Separation of brompheniramine enantiomers in capillary electrophoresis and study of chiral recognition mechanisms of cyclodextrins using NMR-spectroscopy, UV spectrometry, ESI-MS and x-ray crystallography"
    J. Chromatogr. A 875: 471-484 (2000)


 vor 2000

  • J. Breitkreutz, T. Wessel, J. Boos
    "Dosage Forms for Peroral Drug Administration to Children"
    Paediatr. Perinatal Drug Therap. 3: 25-33 (1999)
  • H. Bensmann, B. Borchard, J. Breitkreutz, C. Cloer, C. Drengenberg, G. Heun, E. Kuhlmann, U. Kuhland, R. Möwes, S. Remmerbach, C. Walz
    "Zukunftsorientierte Arzneimittelentwicklung - Beispiele für biomedizinisch orientierte Forschung in der Pharmazeutischen Technologie"
    Forschungsjournal der WWU Münster 7: 16-20 (1998)
  • J. Breitkreutz
    "Prediction of Intestinal Drug Absorption Properties by Three-Dimensional Solubility Parameters"
    Pharm. Res. 15: 1370-1375 (1998)
  • Y. Topaloglu, G. Yener, J. Breitkreutz
    "Preparation of sulindac with skimmed milk via freeze-drying"
    Pharmazie 53: 327-329 (1998)
  • G. Heun, J. Breitkreutz
    "Experimental and molecular modelling studies on the incompatibility of phenolic preservatives with polyethylene glycols"
    Pharm. Pharmacol. Lett. 6: 60-63 (1996)
  • J. Breitkreutz
    "Molecular Modeling-Studien und experimentelle Untersuchungen zur molekularen Struktur von Polyethylenglykolen und zu deren Wechselwirkungen mit Wasser und Phenol"
    Dissertation, Universität Münster (1996), erschienen im Shaker Verlag Aachen, ISBN 3-8265-1599-4R.
  • Gröning, V. Baroth, J. Breitkreutz
    "Nanoparticles in plant extracts - investigations into the colloidal structure of aqueous infusions of black tea"
    Pharm. Pharmacol. Lett. 2: 77-79 (1995)
  • G. Heun, J. Breitkreutz
    "Structures and molecular attributes of polyethylene glycols"
    Pharmazie 49: 562-566 (1994)
  • J. Breitkreutz
    "Entwicklung eines Computerprogramms zur rechnerunterstützten Herstellung von Augentropfen"
    Diplomarbeit, E. M. Arndt-Universität Greifswald (1992)