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Publikationen des Arbeitskreises Seidlitz


F. Matin-Mann, Z. Gao, J. Schwieger, M. Ulbricht, V. Domsta, S. Senekowitsch, W. Weitschies, A. Seidlitz, K. Doll, M. Stiesch, T. Lenarz, V. Scheper
Individualized, Additively Manufactured Drug-Releasing External Ear Canal Implant for Prevention of Postoperative Restenosis: Development, In Vitro Testing, and Proof of Concept in an Individual Curative Trial. 
Pharmaceutics 14 (2022) 1242


T. Auel, L. Großmann, L. Schulig, W. Weitschies, A. Seidlitz
The EyeFlowCell: Development of a 3D-Printed Dissolution Test Setup for Intravitreal Dosage Forms.
Pharmaceutics 13 (2021) 1394

H.H. Blume, M. Mehta, G. Beuerle, A. Dorantes, G. Hempel, W. Jiang, A. Kovar, J. Lee, H. Potthast, B. Schug, A. Seidlitz, N Tampal, Y.-C. Tsang, J. Walstab, J. Welink
The Global Bioequivalence Harmonisation Initiative (GBHI): Report of EUFEPS/AAPS fourth conference.
Eur. J.  Pharm. Sci. 167 (2021) 105987

V. Domsta, A. Seidlitz
3D-Printing of Drug-Eluting Implants: An Overview of the Current Developments Described in the Literature.
Molecules 26 (2021) 4066

J. Krause, L. Müller, D. Sarwinska, A. Seidlitz, M. Sznitowska, W. Weitschies
3D Printing of Mini Tablets for Pediatric Use.
Pharmaceuticals 14 (2021) 143


A. Hermans, P. Dorozynski, F.J. Muzzio, H. Li, S. Nielsen, S. Chen, C. Reppas, S. Klein, S. Patel, M. Wacker, K. Thakker, K. Pruessmann, A. Seidlitz, T.K. Ghosh, Y. Yang, D. Willett, G. Hochhaus, J. Tay, C.V. Liew, P.W.S Heng, C.C. Sun, J. Kraemer, M.R.C Marques
Workshop Report: USP Workshop on Advancements in In Vitro Performance Testing of Drug Products.
Diss. Technol. 27 (2020) 52-70


M. Wentzlaff, V. Senz V, A. Seidlitz
Evaluation of the suitability of a fluidized bed process for the coating of drug-eluting stents.
Eur. J. Pharm. Biopharm. 139 (2019) 85-92

K. Pruessmann, M. Wentzlaff, R. Schilling, A. Seidlitz
Influence of dissolution vessel geometry and dissolution medium on in vitro dissolution behaviour of triamterene-coated model stents in different test setups.
AAPS PharmSciTech 20 (2019) 27


S. Stein, S. Hadlich, S. Langner, A. Biesenack, N. Zehm, S. Kruschke, M. Oelze, M. Grimm, S. Mahnhardt, W. Weitschies, A. Seidlitz
7.1 T MRI and T2 mapping of the human and porcine vitreous body post mortem.
Eur. J. Pharm. Biopharm. 131(2018) 82-91

W. Kempin, V. Domsta, I. Brecht, B. Semmling, S. Tillmann, W. Weitschies, A. Seidlitz
Development of a dual extrusion printing technique for an acid- and thermo-labile drug.
Eur. J. Pharm. Sci. 123 (2018) 191-198

E. Wirthgen, W. Otten, M. Tuchscherer, A. Tuchscherer, G. Domanska, J. Brenmoehl, J. Günther, D. Ohde, W. Weitschies, A. Seidlitz, E. Scheuch, E. Kanitz
Effects of 1-Methyltryptophan on Immune Responses and the Kynurenine Pathway after Lipopolysaccharide Challenge in Pigs.
Int. J. Mol. Sci.  19 (2018) 3009

W. Kempin, V. Domsta, G. Grathoff, I. Brecht, B. Semmling, S. Tillmann, W. Weitschies, A. Seidlitz
Immediate Release 3D-Printed Tablets Produced Via Fused Deposition Modeling of a Thermo-Sensitive Drug.
Pharm. Res. 35 (2018) 124

S. Stein, T. Auel, W. Kempin, M. Bogdahn, W. Weitschies, A. Seidlitz
Influence of the test method on in vitro drug release from intravitreal model implants containing dexamethasone or fluorescein sodium in poly (D,L-lactide-co-glycolide) or polycaprolactone.
Eur. J. Pharm. Biopharm. 127 (2018) 270-278


M. Probst, M. Schmidt, K. Tietz, S. Klein, W. Weitschies, A. Seidlitz.
In vitro dissolution testing of parenteral aqueous solutions and oily suspensions of paracetamol and prednisolone.
Int. J. Pharm. 532 (2017) 519-527

W. Kempin, A. Baden, W. Weitschies, A. Seidlitz
Glycerol gelatin for 3D-printing of implants using a paste extrusion technique.
Curr. Dir. Biomed. Engin. 3 (2017) 389-392

S. Stein, M. Bogdahn, C. Rosenbaum, W. Weitschies, A. Seidlitz
Distribution of fluorescein sodium and triamcinolone acetonide in the simulated liquefied and vitrectomized Vitreous Model with simulated eye movements.
Eur. J. Pharm. Sci. 109 (2017) 233-243

W. Kempin, C. Franz, L.C. Koster, F. Schneider, M. Bogdahn, W. Weitschies, A. Seidlitz
Assessment of different polymers and drug loads for fused deposition modeling of drug loaded implants.
Eur. J. Pharm. Biopharm. 115 (2017) 84-93

M. Probst, J.P. Kühn, C. Modeß, E. Scheuch, A. Seidlitz, N. Hosten, W. Siegmund, W. Weitschies
Muscle injury after intramuscular administration of diclofenac: A case report supported by magnetic resonance imaging.
Drug Saf. - Case Rep.  4(2017) 7


M. Probst, J.P. Kühn, E. Scheuch, A. Seidlitz, S. Hadlich, K. Evert, S. Oswald, W. Siegmund, W.  Weitschies
Simultaneous magnetic resonance imaging and pharmacokinetic analysis of  intramuscular depots.
J. Control. Release 227 (2016) 1-12

S. Stein, M. Bogdahn, W. Weitschies, A. Seidlitz
Influence of Siluron(R) insertion on model drug distribution in the simulated vitreous body.
Curr. Dir. Biomed. Engin. 2 (2016) 665-668 

M. Probst, M. Schmidt, W. Weitschies, A. Seidlitz
In vitro simulation of distribution processes following intramuscular injection.
Curr. Dir. Biomed. Engin. 2 (2016) 383-386

E. Wirthgen, E. Kanitz, M. Tuchscherer, A. Tuchscherer, G. Domanska, W. Weitschies, A. Seidlitz, E. Scheuch, W. Otten
Pharmacokinetics of 1-methyl-L-tryptophan after single and  repeated subcutaneous application in a porcine model.
Exp. Anim. 65 (2016) 147-155


W. Kempin, S. Kaule, T. Reske, N. Grabow, S. Petersen, S. Nagel, K.P. Schmitz, W. Weitschies,  A. Seidlitz
In vitro evaluation of paclitaxel coatings for delivery via drug-coated balloons.
Eur. J. Pharm. Biopharm. 96 (2015) 322-328

S. Stein, C. Simroth-Loch, S. Langner, S. Hadlich, O. Stachs, N. Grabow, R. Guthoff, W.Weitschies, A. Seidlitz
MR imaging of model drug distribution in simulated vitreous.
Curr. Dir. Biomed. Engin. 1 (2015) 236-239.

A. Seidlitz, W. Schick, T. Reske, V. Senz, N. Grabow, S. Petersen, S. Nagel, W. Weitschies
In vitro study of sirolimus release from a drug-eluting stent: Comparison of the release profiles obtained using different test setups.
Eur. J. Pharm. Biopharm. 93 (2015) 328-338

A. Seidlitz, M. Wentzlaff, W. Weitschies
Controlling drug delivery from coronary stents - are we aiming for the right targets?
Ther. Deliv. 6 (2015) 705-720


B. Semmling, S. Nagel, K. Sternberg, W. Weitschies, A. Seidlitz
Impact of different tissue-simulating hydrogel compartments on in vitro release and distribution from drug-eluting stents.
Eur. J. Pharm. Biopharm. 87 (2014) 570-578

A. Seidlitz
Dissolution testing of cardiologic drug-eluting medical devices.
Pharm. Ind. 76 (2014) 1794-1800

M. Wentzlaff, A. Seidlitz, C. Harder, N. Grabow, W. Weitschies
Coating of stents with poly-L-lactide via fluidized-bed process.
Biomed. Tech. 59 (2014) 841-844

A. Seidlitz, W. Kempin, T. Reske, S. Kaule, N. Grabow, S. Petersen, C. Harder, S. Nagel,. W. Weitschies
Evaluation of the influence of contact time and inflation pressure on drug transfer from drug-coated balloons.
Biomed. Tech. 59 (2014) 375-378

C. Loch, M. Bogdahn, S. Stein, S. Nagel, R. Guthoff, W. Weitschies, A. Seidlitz
Simulation of Drug Distribution in the Vitreous Body After Local Drug Application into Intact Vitreous Body and in Progress of Posterior Vitreous Detachment.
J. Pharm. Sci. 103 (2014) 517-526


A. Seidlitz, S. Nagel, B. Semmling, K. Sternberg, H. K. Kroemer, W. Weitschies
In Vitro Dissolution Testing of Drug-Eluting Stents.
Curr. Pharm. Biotech. 14 (2013) 67-75

B. Semmling, S. Nagel, K. Sternberg, W. Weitschies, A. Seidlitz
Development of Hydrophobized Alginate Hydrogels for the Vessel-Simulating Flow-Through Cell and Their Usage for Biorelevant Drug-Eluting Stent Testing.
AAPS PharmSciTech. 14 (2013) 1209-1218

A. Seidlitz, N. Kotzan, S. Nagel, T. Reske, N. Grabow, C. Harder, S. Petersen, K. Sternberg, W. Weitschies
In vitro determination of drug transfer from drug-coated balloons.
PLoS ONE 8 (2013) e83992

B. Semmling, S. Nagel, K. Sternberg, W. Weitschies, A. Seidlitz
Long-term stable hydrogels for biorelevant dissolution testing of drug-eluting stents.
J. Pharm. Technol. Drug Res. 2 (2013) 19


A. Seidlitz, W. Weitschies
In-vitro dissolution methods for controlled release parenterals and their applicability to drug-eluting stent testing.
J. Pharm. Pharmacol. 64 (2012) 969-985

K. Sternberg, M. Gratz, K. Koeck, J. Mostertz, R. Begunk, M. Loebler, B. Semmling, A. Seidlitz, P. Hildebrandt, G. Homuth, N. Grabow, C. Tuemmler, W. Weitschies, K. Schmitz, H. K. Kroemer
Magnesium used in bioabsorbable stents controls smooth muscle cell proliferation and stimulates endothelial cells in vitro.
J. Biomed. Mater. Res. Part B 100 (2012) 41-50

C. Loch, S. Zakelj, A. Kristl, S. Nagel, R. Guthoff, W. Weitschies, A. Seidlitz
Determination of permeability coefficients of ophthalmic drugs through different layers of porcine, rabbit and bovine eyes.
Eur. J. Pharm. Sci. 47 (2012) 131-138

C. Loch, S. Nagel, R. Guthoff, A. Seidlitz A, W. Weitschies
The Vitreous Model – a new in vitro test method simulating the vitreous body.
Biomed. Tech. 57 (2012) 281-284

B. Semmling, A. Seidlitz, E. Trip, C. Schnittker, T. Reske, K. Sternberg, W. Weitschies
Examination of steroid release from screw-in pacing leads.
Biomed. Tech. 57 (2012) 273-276

K. Sternberg, S. Petersen, N. Grabow, F. Luderer, A. Bohl, T. Reske, S. Siewert, I. Minrath, A. Seidlitz, W. Weitschies, H. Meyer zu Schwabedissen, H. K. Kroemer, K. P. Schmitz
Implant-associated local drug delivery systems for different medical applications
Biomed. Tech. 57 (2012) 393-396

M. Wentzlaff, A. Seidlitz, S. Nagel, C. Harder, C. Schnittker, E. Trip, T. Reske, K. Sternberg, W. Weitschies
Coating of collars via fluidised-bed process.
Biomed. Tech. 57 (2012) 18-21

A. Seidlitz, S. Nagel, B. Semmling, S. Petersen, T. Reske, W. Schmidt, N. Grabow, K. Sternberg K, W. Weitschies
In vitro estimation of drug loss during the implantation procedure of drug-eluting stents.
Biomed. Tech. 57 (2012) 403-406


A. Seidlitz, S. Nagel, B. Semmling, N. Grabow, H. Martin, V. Senz, C. Harder, K. Sternberg, K. Schmitz, H. K. Kroemer, W. Weitschies
Examination of drug release and distribution from drug-eluting stents with a vessel-simulating flow-through cell.
Eur. J. Pharm. Biopharm. 78 (2011) 36-48

A. Seidlitz, S. Nagel, B. Semmling, N. Grabow, K. Sternberg, W. Weitschies
Biorelevant dissolution testing of drug-eluting stents: experiences with a modified flow-through cell setup.
Diss. Technol. 18 (2011) 26-34


A. Neubert, K. Sternberg, S. Nagel, C. Harder, K. P. Schmitz, H. K. Kroemer, W. Weitschies
Development of a vessel-simulating flow-through cell method for the in vitro evaluation of release and distribution from drug-eluting stents.
J. Control. Release 130 (2008) 2-8