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Publikationen Jun.-Prof. Dr. M. Hacker

Hinkelmann S, Springwald AH, Starke A, Kalwa H, Wölk C, Hacker MC, Schulz-Siegmund M.
Microtissues from mesenchymal stem cells and siRNA-loaded cross-linked gelatin microparticles for bone regeneration.
Mater Today Bio. 13:100190 (2021).

Kroschwald LM, Allerdt F, Bernhardt A, Rother S, Zheng K, Maqsood I, Halfter N, Heinemann C, Möller S, Schnabelrauch M, Hacker MC, Rammelt S, Boccaccini AR, Hintze V.
Artificial Extracellular Matrices Containing Bioactive Glass Nanoparticles Promote Osteogenic Differentiation in Human Mesenchymal Stem Cells.
Int J Mol Sci. 22(23):12819 (2021).

Krieghoff J, Gronbach M, Schulz-Siegmund M, Hacker MC.
Biodegradable macromers for implant bulk and surface engineering.
Biol Chem. 402(11):1357-1374 (2021).

Roerig J, Schiller L, Kalwa H, Hause G, Vissiennon C, Hacker MC, Wölk C, Schulz-Siegmund M.
A focus on critical aspects of uptake and transport of milk-derived extracellular vesicles across the Caco-2 intestinal barrier model.
Eur J Pharm Biopharm. 166:61-74 (2021).

Krieghoff J, Rost J, Kohn-Polster C, Müller BM, Koenig A, Flath T, Schulz-Siegmund M, Schulze FP, Hacker MC.
Extrusion-Printing of Multi-Channeled Two-Component Hydrogel Constructs from Gelatinous Peptides and Anhydride-Containing Oligomers.
Biomedicines 9(4):370 (2021).

Nawaz HA, Schröck K, Schmid M, Krieghoff J, Maqsood I, Kascholke C, Kohn-Polster C, Schulz-Siegmund M, Hacker MC.
Injectable oligomer-cross-linked gelatine hydrogels via anhydride-amine-conjugation.
J Mater Chem B. 9(9):2295-2307 (2021).

  • Kuzmenka D, Sewohl C, König A, Flath T, Hahnel S, Schulze FP, Hacker MC, Schulz-Siegmund M.
    Sustained calcium(II)-release to impart bioactivity in hybrid glass scaffolds for bone tissue engineering.
    Pharmaceutics 12(12):E1102, 2020.
  • Gronbach M, Mitrach F, Möller S, Rother S, Friebe S, Mayr SG, Schnabelrauch M, Hintze V, Hacker MC, Schulz-Siegmund M.
    A versatile macromer-based glycosaminoglycan (sHA3) decorated biomaterial for pro-osteogenic scavenging of Wnt antagonists.
    Pharmaceutics 12(11): E1037, 2020.
  • Wölk C, Nawaz H A, Maqsood I, Strati F, Brezesinski G, Hause G, Schulz-Siegmund M, and Hacker MC.
    Amphiphilic functionalized oligomers: a promising strategy for the postfabrication functionalization of liposomes.
    Adv. Mater. Interfaces 7: 2001168, 2020.
  • Gronbach M, Mitrach F, Lidzba V, Müller B, Möller S, Rother S, Salbach-Hirsch J, Hofbauer L C, Schnabelrauch M, Hintze V, Hacker MC, Schulz-Siegmund M.
    Scavenging of Dickkopf-1 by macromer-based biomaterials covalently decorated with sulfated hyaluronan displays pro-osteogenic effects,
    Acta Biomaterialia 114:76-89, 2020. (Publikationspreis des SFB-TRR67 Herbst 2020)
  • Krieghoff J, Picke AK, Salbach-Hirsch J, Rother S, Heinemann C, Bernhardt R, Kascholke C, Möller S, Rauner M, Schnabelrauch M, Hintze V, Scharnweber D, Schulz-Siegmund M, Hacker MC, Hofbauer LC, Hofbauer C.
    Increased pore size of scaffolds improves coating efficiency with sulfated hyaluronan and mineralization capacity of osteoblasts.
    Biomater Res. 23:pp.26, 2019.
  • Walker S, Schönfelder J, Tugtekin SM, Wetzel C, Hacker MC, Schulz-Siegmund M.
    Stabilization and Sterilization of Pericardial Scaffolds by Ultraviolet and Low-Energy Electron Irradiation. 
    Tissue Eng Part C Methods. 24(12):717-729, 2018.
  • Schneider M, Lohrenz A, Cross M, Hacker MC, Simon JC, Savkovic V.
    A human serum-enriched medium formulation supports high viability and marker expression in primary melanocyte cultures from the outer root sheath and epidermis.
    Exp Dermatol. 27(1):87-90, 2018.
  • Kascholke C, Hendrikx S, Flath T, Kuzmenka D, Dörfler HM, Schumann D, Gressenbuch M, Schulze FP, Schulz-Siegmund M, Hacker MC.
    Biodegradable and adjustable sol-gel glass based hybrid scaffolds from multi-armed oligomeric building blocks.
    Acta Biomater. 63:336-349, 2017.
  • Wersig T, Hacker MC, Kressler J, Mäder K.
    Poly(glycerol adipate) - indomethacin drug conjugates - synthesis and in vitro characterization.
    Int J Pharm. 531(1):225-234, 2017.
  • Kohn-Polster C, Bhatnagar D, Woloszyn DJ, Richtmyer M, Starke A, Springwald AH, Franz S, Schulz-Siegmund M, Kaplan HM, Kohn J, Hacker MC.
    Dual-Component Gelatinous Peptide/Reactive Oligomer Formulations as Conduit Material and Luminal Filler for Peripheral Nerve Regeneration.
    Int J Mol Sci. 18: 1104, 2017.
  • Schwabe K, Ewe A, Kohn C, Loth T, Aigner A, Hacker MC, Schulz-Siegmund M.
    Sustained delivery of siRNA poly- and lipopolyplexes from porous macromer-crosslinked gelatin gels.
    Int J Pharm. 526(1-2):178-187, 2017.
  • Müller BM, Loth R, Hoffmeister PG, Zühl F, Kalbitzer L, Hacker MC, Schulz-Siegmund M.
    Surface modification of copolymerized films from three-armed biodegradable macromers - An analytical platform for modified tissue engineering scaffolds.
    Acta Biomater. 51:148-160, 2017.
  • Kascholke C, Loth T, Kohn-Polster C, Möller S, Bellstedt P, Schulz-Siegmund M, Schnabelrauch M, Hacker MC.
    Dual-Functional Hydrazide-Reactive and Anhydride-Containing Oligomeric Hydrogel Building Blocks.
    Biomacromolecules 18(3):683-694, 2017.
  • van der Smissen A, Hoffmeister PG, Friedrich N, Watarai A, Hacker MC, Schulz-Siegmund M, Anderegg U:
    Artificial extracellular matrices support cell growth and matrix synthesis of human dermal fibroblasts in macroporous 3D scaffolds.
    J Tissue Eng Regen Med 11(5): 1390-1402, 2017.
  • Sülflow K, Schneider M, Loth T, Kascholke C, Schulz-Siegmund M, Hacker MC, Simon JC, Savkovic V.
    Melanocytes from the outer root sheath of human hair and epidermal melanocytes display improved melanotic features in the niche provided by cGEL, oligomer-cross-linked gelatin-based hydrogel.
    J Biomed Mater Res A 104(12):3115-3126, 2016.
  • Kohn C, Klemens JM, Kascholke C, Murthy NS, Kohn J, Brandenburger M, Hacker MC.
    Dual-component collagenous peptide/reactive oligomer hydrogels as potential nerve guidance materials - from characterization to functionalization.
    Biomater Sci. 4(11):1605-1621, 2016.
  • Picke A-K, Salbach-Hirsch J, Hintze V, Rother S, Rauner M, Kascholke C, Möller S, Bernhardt R, Rammelt S, Pisabarro MT, Ruiz-Gómez G, Schnabelrauch M, Schulz-Siegmund M, Hacker MC, Scharnweber D, Hofbauer C, Hofbauer LC.
    Sulfated hyaluronan improves bone regeneration of diabetic rats by binding sclerostin and enhancing osteoblast function.
    Biomaterials 96:11-23, 2016.
  • Hendrikx S, Kascholke C, Flath T, Schumann D, Gressenbuch M, Schulze FP, Hacker MC, Schulz-Siegmund M.
    Indirect rapid prototyping of sol-gel hybrid glass scaffolds for bone regeneration - Effects of organic crosslinker valence, content and molecular weight on mechanical properties.
    Acta Biomater. 35:318-29, 2016.
  • Sedaghati B, Jahroomishirazi R, Starke A, Hacker MC, Schulz-Siegmund M.
    Rat Osteosarcoma Cells as a Therapeutic Target Model for Osteoregeneration via Sclerostin Knockdown.
    Cells Tissues Organs 201(5):366-79, 2016.
  • Savkovic V, Flämig F, Schneider M, Sülflow K, Loth T, Lohrenz A, Hacker MC, Schulz-Siegmund M, Simon JC.
    Polycaprolactone fiber meshes provide a 3D environment suitable for cultivation and differentiation of melanocytes from the outer root sheath of hair follicle.
    J Biomed Mater Res A. 104(1): 26-36, 2016.
  • Hacker MC, Nawaz HA.
    Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine.
    Int J Mol Sci. 16(11): 27677-706, 2015.
  • Roßteuscher-Carl K, Fricke S, Hacker MC, Schulz-Siegmund, M.
    Influence of in line monitored fluid bed granulation process parameters on the stability of Ethinylestradiol.
    Int J Pharm. Int J Pharm. 496(2):751-8, 2015.
  • Loth R, Loth T, Schwabe K, Bernhardt R, Schulz-Siegmund M, Hacker MC.
    Highly adjustable biomaterial networks from three-armed biodegradable macromers.
    Acta Biomater. 26: 82-96, 2015. (Publikationspreis des SFB-TRR67 Herbst 2015)
  • Schröck K, Lutz J, Mändl S, Hacker MC, Kamprad M, Schulz-Siegmund M.
    Co(II)-mediated effects of plain and plasma immersion ion implanted cobalt-chromium alloys on the osteogenic differentiation of human mesenchymal stem cells.
    J Orthop Res. 33(3):325-33, 2015.
  • Savkovic V, Li H, Seon JK, Hacker M, Franz S, Simon JC.
    Mesenchymal stem cells in cartilage regeneration.
    Curr Stem Cell Res Ther 9 :469-88, 2014.
  • Loth T, Hötzel R, Kascholke C, Anderegg U, Schulz-Siegmund M, Hacker MC.
    Gelatin-based biomaterial engineering with anhydride-containing oligomeric cross-linkers.
    Biomacromolecules 15: 2104-18, 2014. (Publikationspreis des SFB-TRR67 Herbst 2014)
  • Steinhagen M, Hoffmeister PG, Nordsieck K, Hötzel R, Baumann L, Hacker MC, Schulz-Siegmund M, Beck-Sickinger AG.
    Matrix metalloproteinase 9 (MMP-9) mediated release of MMP-9 resistant stromal cell-derived factor 1α (SDF-1α) from surface modified polymer films.
    ACS Appl Mater Interfaces 6: 5891-9, 2014.
  • Roßteuscher-Carl K, Fricke S, Hacker MC, Schulz-Siegmund M.
    In-line monitoring of particle size in a fluid bed granulator: investigations concerning positioning and configuration of the sensor.
    Int J Pharm 466: 31-7, 2014.
  • Mai M, Hempel U, Hacker MC, Dieter P.
    Effects of HyStem™-HP Hydrogel Elasticity on Osteogenic Differentiation of Human Mesenchymal Stromal Cells. 
    Cell Mol Bioeng 7: 155-164, 2014.
  • Wei R, Oeser T, Barth M, Weigl N, Lübs A, Schulz-Siegmund M, Hacker MC, Zimmermann W.
    Turbidimetric analysis of the enzymatic hydrolysis of polyethylene terephthalate nanoparticles. J Mol Catal B:
    Enzym 103: 72–78. 2014.
  • Schneider H, Sedaghati B, Naumann A, Hacker MC, Schulz-Siegmund M.
    Gene silencing of chordin improves BMP-2 effects on osteogenic differentiation of human adipose tissue-derived stromal cells.
    Tissue Eng Part A 20:335-45, 2014.
  • Schröck K, Schneider H, Lutz J, Hacker MC, Mändl S, Kamprad M, Schulz-Siegmund M.
    Cytocompatibility of nitrogen plasma ion immersed medical cobalt-chromium alloys.
    J Biomed Mater Res A 102: 1744-54, 2014.
  • Loth T, Hennig R, Kascholke C, Hötzel R, Hacker MC.
    Reactive and stimuli-responsive maleic anhydride containing macromers – multi-functional cross-linkers and building blocks for hydrogel fabrication.
    React Funct Polym. 73:1480–1492, 2013.
  • Penk A, Förster Y, Scheidt HA, Nimptsch A, Hacker MC, Schulz-Siegmund M, Ahnert P, Schiller J, Rammelt S, Huster D.
    The pore size of PLGA bone implants determines the de novo formation of bone tissue in tibial head defects in rats.
    Magn Reson Med. 70: 925-35, 2013.
  • Hassert R, Hoffmeister PG, Pagel M, Hacker M, Schulz-Siegmund M, Beck-Sickinger AG.
    On-resin synthesis of an acylated and fluorescence-labeled cyclic integrin ligand for modification of poly(lactic-co-glycolic acid).
    Chem Biodivers 9: 2648-58, 2012
  • Weber F, Böhme J, Scheidt HA, Gründer W, Rammelt S, Hacker M, Schulz-Siegmund M, Huster D.
    31P and 13C solid-state NMR spectroscopy to study collagen synthesis and biomineralization in polymer-based bone implants.
    NMR Biomed 25: 464-75, 2012.
  • Ambrosch K, Manhardt M, Loth T, Bernhardt R, Schulz-Siegmund M, Hacker MC.
    Open porous microscaffolds for cellular and tissue engineering by lipid templating.
    Acta Biomater 8: 1303-15, 2012.
  • Böhme J, Anderegg U, Nimptsch A, Nimptsch K, Hacker M, Schulz-Siegmund M, Huster D, Schiller J.
    De novo biosynthesis of glycosaminoglycans in the extracellular matrix of skin studied by matrix-assisted laser desorption/ionization mass spectrometry.
    Anal Biochem 421: 791-3, 2012.
  • Klouda L, Perkins KR, Watson BM, Hacker MC, Bryant SJ, Raphael RM, Kasper FK, Mikos AG,
    Thermoresponsive, in situ crosslinkable hydrogels based on N-isopropylacrylamide: Fabrication, characterization and mesenchymal stem cell encapsulation,
    Acta Biomater 7: 1460-7, 2010.
  • Chew SA, Hacker MC, Saraf A, Raphael RM, Kasper FK, Mikos AG.
    Altering amine basicities in biodegradable branched polycationic polymers for nonviral gene delivery.
    Biomacromolecules 11: 600-9, 2010.
  • Kretlow JD, Hacker MC, Klouda L, Ma BB, Mikos AG.
    Synthesis and characterization of dual stimuli responsive macromers based on poly(N-isopropylacrylamide) and poly(vinylphosphonic acid).
    Biomacromolecules 11: 797-805, 2010.
  • Chew SA, Hacker MC, Saraf A, Raphael RM, Kasper FK, Mikos AG.
    Biodegradable branched polycationic polymers with varying hydrophilic spacers for nonviral gene delivery.
    Biomacromolecules 10: 2436-45, 2009.
  • Klouda L, Hacker MC, Kretlow JD, Mikos AG.
    Cytocompatibility evaluation of amphiphilic, thermally responsive and chemically crosslinkable macromers for in situ forming hydrogels.
    Biomaterials 30: 4558-66, 2009.
  • Haesslein A*, Hacker MC*, Ueda H, Ammon DM, Borazjani RN, Kunzler JF, Salamone JC, Mikos AG.
    Matrix modifications modulate ophthalmic drug delivery from photo-cross-linked poly(propylene fumarate)-based networks.
    J Biomater Sci Polym Ed 20: 49-69, 2009.
  • Hacker MC*, Haesslein A*, Ueda H*, Foster WJ, Garcia CA, Ammon DM, Borazjani RN, Kunzler JF, Salamone JC, Mikos AG.
    Biodegradable fumarate-based drug-delivery systems for ophthalmic applications.
    J Biomed Mater Res A 88: 976-89, 2009.
  • Hacker MC, Klouda L, Ma BB, Kretlow JD, Mikos AG.
    Synthesis and Characterization of Injectable, Thermally and Chemically Gelable, Amphiphilic Poly(N-isopropylacrylamide)-Based Macromers.
    Biomacromolecules 9: 1558-70, 2008.
  • Saraf A, Hacker MC, Sitharaman B, Grande-Allen KJ, Barry MA, Mikos AG.
    Synthesis and Conformational Evaluation of a Novel Gene Delivery Vector for Human Mesenchymal Stem Cells.
    Biomacromolecules 9: 818-27, 2008.
  • Haesslein A*, Hacker MC*, Mikos AG.
    Effect of macromer molecular weight on in vitro ophthalmic drug release from photo-crosslinked matrices.
    Acta Biomater 4: 1-10, 2008.
  • Ueda H*, Hacker MC*, Haesslein A*, Jo S, Ammon DM, Borazjani RN, Kunzler JF, Salamone JC, Mikos AG.
    Injectable, In Situ Forming Poly(Propylene Fumarate)-Based Ocular Drug Delivery Systems.
    J Biomed Mater Res A 83: 656-66, 2007.
  • Hacker M, Ringhofer M, Appel B, Neubauer M, Vogel T, Young S, Mikos AG, Blunk T, Goepferich A, Schulz MB.
    Solid lipid templating of macroporous tissue engineering scaffolds.
    Biomaterials 28: 3497-507, 2007.
  • Hacker MC, Mikos AG.
    Trends in tissue engineering research.
    Tissue Eng 12: 2049-57, 2006.
  • Haesslein A*, Ueda H*, Hacker MC*, Jo S, Ammon DM, Borazjani RN, Kunzler JF, Salamone JC, Mikos AG.
    Long-Term Release of Fluocinolone Acetonide Using Biodegradable Fumarate-Based Polymers.
    J Control Release 114: 251-60, 2006.
  • Guse C, Koennings S, Maschke A, Hacker M, Becker C, Schreiner S, Blunk T, Spruss T, Goepferich A.
    Biocompatibility and erosion behavior of implants made of triglycerides and blends with cholesterol and phospholipids.
    Int J Pharm 314: 153-60, 2006.
  • Neubauer M, Hacker M, Bauer-Kreisel P, Weiser B, Fischbach C, Schulz MB, Goepferich A, Blunk T.
    Adipose tissue engineering based on mesenchymal stem cells and basic fibroblast growth factor in vitro.
    Tissue Eng 11: 1840-51, 2005.
  • Lieb E, Milz S, Vogel T, Hacker M, Dauner M, Schulz MB.
    Effects of transforming growth factor beta1 on bonelike tissue formation in three-dimensional cell culture. I. Culture conditions and tissue formation.  
    Tissue Eng 10: 1399-413, 2004.
  • Lieb E*, Hacker M*, Tessmar J, Kunz-Schughart LA, Fiedler J, Dahmen C, Hersel U, Kessler H, Schulz MB, Gopferich A.
    Mediating specific cell adhesion to low-adhesive diblock copolymers by instant modification with cyclic RGD peptides.
    Biomaterials 26: 2333-41, 2004.
  • Neubauer M, Fischbach C, Bauer-Kreisel P, Lieb E, Hacker M, Tessmar J, Schulz MB, Goepferich A, Blunk T.
    Basic fibroblast growth factor enhances PPARgamma ligand-induced adipogenesis of mesenchymal stem cells.
    FEBS Lett 577: 277-83, 2004.
  • Fischbach C, Spruss T, Weiser B, Neubauer M, Becker C, Hacker M, Gopferich A, Blunk T.
    Generation of mature fat pads in vitro and in vivo utilizing 3-D long-term culture of 3T3-L1 preadipocytes.
    Exp Cell Res 300: 54-64, 2004.
  • Fischbach C, Seufert J, Staiger H, Hacker M, Neubauer M, Gopferich A, Blunk T.
    Three-dimensional in vitro model of adipogenesis: comparison of culture conditions.
    Tissue Eng 10: 215-29, 2004.
  • Hacker M, Tessmar J, Neubauer M, Blaimer A, Blunk T, Göpferich A, Schulz MB.
    Towards biomimetic scaffolds: Anhydrous scaffold fabrication from biodegradable amine-reactive diblock copolymers.
    Biomaterials 24:4459-4473, 2003.
  • Lieb E, Tessmar J, Hacker M, Fischbach C, Rose D, Blunk T, Mikos A, Göpferich A, Schulz MB.
    Poly(D,L-lactic acid)-poly(ethylene glycol)-monomethyl ether Diblock Copolymers Control Adhesion and Osteoblastic Differentiation of Marrow Stromal Cells.
    Tissue Eng 9: 71 – 84, 2003.
  • Hacker MC, Krieghoff J, and Mikos AG,
    “Synthetic Polymers,”
    in Principles of Regenerative Medicine, 3rd Ed., Atala A, Lanza R, Mikos AG, and Nerem R, Eds.,
    Elsevier Academic Press, San Diego, 2019, pp. 559-590.
  • Sedaghati B, Hoyer J, Aigner A, Hacker MC, Schulz-Siegmund M.
    Controlled Release Technologies for RNAi Strategies
    in Regenerative Medicine. In: Regenerative Medicine - from Protocol to Patient,
    Steinhoff G, Ed., Springer, 2016.
  • Hacker MC, Hötzel R, Hoffmeister PG, Schulz-Siegmund M.
    Synthesis, Processing, and Characterization of Ceramic Nanobiomaterials for Biomedical Applications.
    In: Nanobiomaterials Handbook, Sitharaman B, Ed.,
    CRC Press Taylor & Francis Group, Boca Raton, USA, 2011, Chapter 3.
  • Hacker MC, Mikos AG.
    Synthetic polymers.
    In: Principles of Regenerative Medicine, 2nd edition, Atala A, Lanza RP, Thomson JA, Nerem RM, Eds.,
    Elsevier Academic Press, San Diego, 2011, pp. 587-622.   
  • Hacker MC, Ambrosch K, Schulz-Siegmund M.
    Macroporous Polymer Scaffolds through Leaching Processes.
    In: Macroporous Polymers: Production Properties and Biotechnological/Biomedical Applications, Mattiasson B, Kumar A, Galeaev IY, Eds.,
    CRC Press Taylor & Francis Group, Boca Raton, USA, 2009, pp. 49-82.