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Selected Publications

  Phenanthroindolizidine Alkaloids Isolated from Tylophora ovata as Potent Inhibitors of Inflammation, Spheroid Growth, and Invasion of Triple-Negative Breast Cancer
Reimche I, Yu H, Ariantari NP, Liu Z, Merkens K, Rotfuß S, Peter K, Jungwirth U, Bauer N, Kiefer D, Neudörfl J-M, Schmalz H-G, Proksch P, Teusch N, 2022, International Journal of Molecular Science 23 (18): 10319, DOI: 10.3390/ijms231810319

Total Synthesis of (+)‐Erogorgiaene and the Pseudopterosin A−F Aglycone via Enantioselective Cobalt‐Catalyzed Hydrovinylation
Movahhed S, Westphal J, Kempa A, Schumacher C E, Sperlich J, Neudörfl J-M, Teusch N, Hochgürtel M, Schmalz H-G, 2022, Chemistry – A European Journal 27(45): 11574–11579, DOI: 10.1002/chem.202101863


Polyketides from the marine-derived fungus Aspergillus falconensis: In silico and in vitro cytotoxicity studies
El-Kashef DH, Youssef FS, Reimche I, Teusch N, Müller WEG, Lin W, Frank M, Liu Z, Proksch P. 2021 Bioorg Med Chem., Jan 1 (29): 115883, DOI: 10.1016/j.bmc.2020.115883


Pseudopterosin and tylophorinine suppress cell growth in 3D spheroid co-culture models of pancreatic ductal adenocarcinoma
Xie B, Hänsel J, Mundorf V, Betz J, Reimche I, Erkan M, Büdeyri I, Barlas T, Gesell A, De Bank P, Mrsny R, Teusch N, 2020, Bioengineering 7 (2): 57, DOI: 10.3390/bioengineering7020057


Recent developments of 3D models of the tumor microenvironment for cutaneous melanoma: Bridging the gap between the bench and the bedside?
Hölken J M, Teusch N, 2020, Journal of Translational Science 7: 1-7, DOI: 10.15761/JTS.1000388


The Birch Bracket Medicinal Mushroom, Fomitopsis betulina (Agaricomycetes) - Bioactive Source for Beta-Glucan Fraction with Tumor Cell Migration Blocking Ability
Sari M, Toepler K, Roth C, Teusch N, Hambitzer R. 2020, Int J Med Mushrooms, 22(1): 1-13, DOI:10.1615/IntJMedMushrooms.2019033291


Azaphilones from the Red Sea Fungus Aspergillus falconensis
El-Kashef DH, Youssef FS, Hartmann R, Knedel TO, Janiak C, Lin W, Reimche I, Teusch N, Liu Z, Proksch P. 2020, Marine Drugs, 18(4): 204, DOI: 10.3390/md18040204


Comparison of two-and three-dimensional cancer models for assessing potential cancer therapeutics
Xie B, Teusch N, Mrsny R, 2020, Biomaterials for Cancer Therapeutics 2: 399-423, DOI: 10.1016/B978-0-08-102983-1.00014-4

  Ketamine increases proliferation of human iPSC-derived neuronal progenitor cells via insulin-like growth factor 2 and indepenpendent of the NMDA receptor
Grossert A, Mehrjardi NZ, Bailey SJ, Lindsay MA, Hescheler J, Saric T, Teusch N, 2019, Cells 8: 1139, DOI: 10.3390/cells8101139
  Azaphilone pigments and macrodiolides from the coprophilous fungus Coniella fragariae
Yu H, Sperlich J, Hofert SP, Janiak C, Teusch N, Stuhldreier F, Wesselborg S, Wang C, Kassack MU, Dai H, Liu Z, Proksch P, 2019, Fitoterapia 137: 104249, DOI: 10.1016/j.fitote.2019.104249

Novel 3,4-dihydroisocoumarines inhibit human P-gp and BCRP in multidrug resistant tumors and demonstrate substrate inhibition of yeast Pdr5
Sachs J, Döhl K, Weber A, Bonus M, Gohlke H, Pietruszka J, Schmitt L, Teusch N, 2019, Frontiers in Pharmacology 10 (400), DOI: 10.3389/fphar.2019.00400

  Pseudopterosin inhibits proliferation and 3D invasion in triple-negative breast cancer by agonizing glucocorticoid receptor alpha
Sperlich J & Teusch N, 2018, Molecules 23(8): 1992, DOI: 10.3390/molecules23081992
  Selective inhibition of the P-gp transporter by goniothalamin derivatives sensitizes resistant cancer cells to chemotherapy
Sachs J, Kadioglu O, Weber A, Mundorf V, Betz J, Efferth T, Pietruszka J, Teusch N, 2018, Journal of Natural Medicines 73(1): 226-235, DOI: 10.1007/s11418-018-1230-x
  Synthetic indolactam V analogs as inhibitors of PAR2 induced calcium mobilization in triple negative breast cancer cells
Stein J, Stahn S, Neudörfl JM, Sperlich J, Schmalz HG, Teusch N, 2018, ChemMedChem 13(2): 147-154, DOI: 10.1002/cmdc.201700640

Azaphilone derivatives from the dung-inhabiting fungus Coniella fragariae inhibit NF-κB activation and reduce tumor cell migration
Yu H, Sperlich J, Mándi A, Kurtán T, Dai H, Teusch N, Guo ZY, Zou K, Liu Z, Proksch P, 2018, Journal of Natural Products 81: 2493-2500, DOI: 10.1021/acs.jnatprod.8b00540


The marine natural product pseudopterosin blocks cytokine release of triple-negative breast cancer and monocytic leukemia cells by inhibiting NF-κB signaling
Sperlich J, Kerr R, Teusch N, 2017, Marine Drugs 15(9): 262-276, DOI: 10.3390/md15090262


Synthesis and cytotoxic activities of goniothalamins and derivatives
Weber A, Döhl K, Sachs J, Nordschild AC, Schröder D, Kulik A, Fischer T, Schmitt L, Teusch N, Pietruszka J, 2017, Biorg. Med. Chem. 6(16): 31101-4, DOI: 10.1016/j.bmc.2017.02.004


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