Publikationen
Originalarbeiten
M.Schäfer-Korting, M.Höltje, H.C.Korting and H.-D.Höltje
Innovative Agents for Actinic Keratosis and Nanocarriers Enhancing Skin Penetration
Skin Pharmacol Physiol 23, 6-10, 2010
M.Höltje, A.Richartz, B.Zdrazil, A.Schwanke, B.Dugovic, C. Murruzzu, H.U.Reissig, H.C.Korting, B.Kleuser, H.-D.Höltje and M.Schäfer-Korting
Human polymerase alpha inhibitors for skin tumors. Part 2. Modeling, synthesis and influence on normal and transformed keratinocytes of new thymidine and purine derivatives
J.Enzyme Inhib Med Chem 25, 250-265, 2010
B.Zdrazil, A.Schwanke, B.Schmitz, M.Schäfer-Korting and H.-D. Höltje
Molecular Modeling Studies of New Potential Human DNA Polymerase alpha Inhibitors
J.Enzyme Inhib Med Chem 25, in press 2010
Originalarbeiten
P.Hillmann, G.-Y.Ko, A.Spinrath, A.Raulf, I.von Kügelgen, S.C.Wolff, R.A,Nicholas, E.Kostenis, H.-D.Höltje and C.Müller
Key determinants of nucleotide-activated P2Y2 receptor function revealed by chemical and Pharmacological experiments, mutagenesis and homology modelling.
J.Med.Chem. 52, 2762-2775 (2009)
M.Crescente, G.Jessen, S.Momi, H.-D.Höltje, P.Gresele, C.Cerletti and G.de Gaetano
Interactions of gallic acid, resveratrol, quercetin and aspirin at the platelet Cox-1 level.
Thrombosis and Haemostasis 102, 336-346 (2009).
Originalarbeiten
Y. Thielmann, J. Mohrlüder, B. W. Koenig, T. Stangler, R. Hartmann, K. Becker, H.-D. Höltje and D. Willbold
An Indole-Binding Site is a Major Determinant of the Ligand Specificity of the GABA Type A Receptor-Associated Protein GABARAP
ChemBioChem 9, 1967-1775 (2008)
H.-D. Höltje
Drug Design: Was theoretische Verfahren in der Arzneistoffentwicklung leisten.
Pharm.Ztg. 153, 4692-4701 (2008)
A. Richartz, M. Höltje, B. Brandt, M. Schäfer-Korting und H.-D. Höltje
Targeting human DNA polymerase α for the inhibition of keratinocyte proliferation.
Part 1. Homology model, active site architecture and ligand binding
Journal of Enzyme Inhibition and Medicinal Chemistry 23, 94-100 (2008)
T.Kaimann, S.Metzger, K.Kuhlmann, B.Brandt, H.-D. Höltje and D.Riesner
Molecular model of an a-helical prion-prion dimer and its monomeric subunits as derived from chemical cross-linking and molecular modelling.
J.Biol.Chem. 376, 582-596 (2008)
J.Antony, K.Kellersohn, M.Mohr-Andrä, S.Prilla, C.Tränkle, K.Mohr, T.Disignini, C.Dallanoce, M.de Amici, M.Muth, U.Holzgrabe, S.Bertoni, E.Barocelli, H.-D.Höltje, J.Schrobang and A.Christopoulos
Dualsteric GPCR targeting: A novel route to binding and signaling pathway selectivity.
FASEB J. 23, 442-450 (2008)
Thomas Hohlfeld, Norbert Zimmermann, Artur-Aron Weber, Gisela Jessen, Horst Weber, Karsten Schrör, Hans-Dieter Höltje, Rainer Ebel
Pyrazole analgesics prevent the antiaggregatory effect of aspirin and preserve platelet thromboxane synthesis
J.Thromb.Haemost. 6, 166-173 (2008)
Originalarbeiten
S. Karkola , H.-D. Höltje, K. WähäläA Three-dimensional Model of CYP19 Aromatase Using Rabbit CYP2C5 as a Template. J. Steroid Biochem. Mol. Biol. 105, 63-70, (2007)Birgit Schlegel, Christian Laggner, Rene Meier, Thierry Langer, David Schnell, Roland Seifert, Holger Stark, Hans-Dieter Höltje and Wolfgang SipplGeneration of a homology model of the human histamine H3 receptor for ligand docking and pharmacophore-based screening J. Comput. Aided-Design, 21, 437-53, (2007)Dorothea Jäger, Caroline Schmalenbach, Stefanie Prilla, Jasmin Schrobang, Anna Kebig, Matthias Sennwitz, Eberhard Heller, Christian Tränkle, Ulrike Holzgrabe, Hans-Dieter Höltje und Klaus Mohr Allosteric small moleculares unveil a role of an extracellular E2/TM7 junction for GPCR ActivationJ. Biol.Chem. 282, 34968-76 (2007)M. Rahnasto, C. Wittekindt, R.O. Juvonen, M. Turpeinen, A. Petsalo, O. Pelkonen, A. Poso, G. Stahl, H.-D. Höltje, H. RaunioIdentification of inhibitors of the nicotine metabolising CYP2A6 enzyme - an in silico approach The Pharmacogenomics Journal 8, 328-338 (2007)
Abstracts
G.-Y. Ko, P. Hillmann, C.E. Müller und H.-D. Höltje
Using Molecular Modelling tools to define the putative binding site of a human P2Y2-receptor model
"Darmstädter Molecular Modelling Workshop"
15.05. -18.05.07, Erlangen
B. Zdrazil, M. Höltje, B. Brandt, M. Schäfer-Korting und H.-D. Höltje
Molecular Dynamics Simulations of new putative human DNA pol a inhibitors for treatmant of excessive kertinocyte proliferation
"Darmstädter Molecular Modelling Workshop"
15.05. -18.05.07, Erlangen
Originalarbeiten
J.C. Hermann, L. Ridder, A.J. Mulholland und H.-D. Höltje
Molecular mechanics of antibiotic resistance: QM/MM modelling of deacylation in a class A ß-lactamase
Org.Biomol.Chem. 4, 206-210 (2006)
B. Schlegel, W. Sippl, und H.-D. Höltje
Molecular Dynamics Simulations of Bovine Rhodopsin: Influence of Protonation States and Different Membrane Mimicking Environments
J. Mol. Mod., 12, 49-64 (2006)
S. Prilla, J. Schrobang, J. Ellis, H.-D. Höltje und K. Mohr
Allosteric Interactions with Muscarinic Acetylcholine Receptors: Complex Role of the Conserved Tryptophan M2 422Trp in a Critical Cluster of Amino Acids for Baseline Affinity, Subtype Selectivity, and Cooperativity
Mol. Pharmacol 70, 181-193 (2006)
Abstracts
J. Schrobang und H.-D. Höltje
Molecular dynamics simulations on a new and improved model of the human muscarinic M2 receptor
"Frontiers in Medicinal Chemistry"
12.03.-15.03.06, Frankfurt am Main
N.Sonnenberg und H.-D. Höltje
The thermodynamic properties of 2-propanol a molecular modeling study
"DPhG-Doktorandentagung"
06.09. - 08.09.2006, Nürnberg-Heroldsberg
M. Kirov, J. Schrobang und H.-D. Höltje
Molecular dynamics simulations of muscarinic M2-receptor/ligand complexes
"DPhG-Doktorandentagung"
06.09. - 08.09.2006, Nürnberg-Heroldsberg
F. Kleis und H.-D. Höltje
Molecular modelling on the binding mode of the human protein kinase CK2 inhibitors
"DPhG-Doktorandentagung"
06.09. - 08.09.2006, Nürnberg-Heroldsberg
G. Ko und H.-D. Höltje
Homology modelling and investigation of the putative binding site of the human P2Y2-receptor
"DPhG-Doktorandentagung"
06.09. - 08.09.2006, Nürnberg-Heroldsberg
M. Volkmar und H.-D. Höltje
THEORETICAL INVESTIGATIONS ON PROTEIN-PROTEIN INTERACTIONS
"DPhG-Doktorandentagung"
06.09. - 08.09.2006, Nürnberg-Heroldsberg
Originalarbeiten
S. Blumenthal, A.K. Kiemer, M. Höltje, B. Brandt, S.Zahler, A.M. Vollmar und H.-D. Höltje
Metalloporphyrins are Able to Inactivate Caspase-3
FASEB Journal, 19, 1272-1279 (2005)
K. Jöhren und H.-D. Höltje
Different Environments for a Realistic Simulation of GPCRs- Application to the M2 Muscarin Receptor
Archiv der Pharmazie 338, 260-267 (2005)
M. Schäfer-Korting, B. Kleuser, M. Ahmed, H.C. Korting und H.-D. Höltje
Glucocorticoids for Human Skin: New Aspects of the Mechanism of Action
Skin Pharmacology an Physiology 18, 103-114 (2005)
B. Rupp, S. Raub, C. Marian und H.-D. Höltje
Molecular Design of 2 sterol-14 a-demethylase homology models and their interactions with the azole antifungals ketoconazole and bifonazole
JCAMD 19, 149-163 (2005)
J.C. Hermann, C. Hensen, L. Ridder, A.J. Mulholland und H.-D. Höltje
Mechanisms of antibiotic resistance: QM/MM modelling of the acylation reaction of a class A ß-lactamase with benzylpenicilin
JACS 127. 4454-4465 (2005)
B. Schlegel, H. Stark,W. Sippl und H.-D. Höltje
Model of a specific human histamine H3 receptor (hH3) binding pocket suitable for virtual drug design
Inflamm. res. 54, 50-51 (2005)
C. Tränkle, A. Dittmann, S. Buller, K. Jöhren, J. Ellis, N. Birdsall, U. Holzgrabe, K. Mohr und H.-D. Höltje
Atypical muscarinic allosteric modulation: Cooperativity among allosteric modulators and an atypical binding topology in muscarinic M2/M2 chimeric receptors
Mol. Pharmacol 68, 1567-1610 (2005)
B. Rupp, B. Brandt und H.-D. Höltje
Dissoziationsverhalten von schnell wirksamen Insulinmutanten
Pharm. Zeitung 150, 2704-2706 (2005)
N. Terzioglu und H.-D. Höltje
Receptor-Based 3D-QSAR Analysis of Seotonin 5-HTID Receptor Agonists
Collect. Czech. Chem. Commun. 70, 1482-1492 (2005)
Abstracts
J. Schrobang und H.-D. Höltje
Molecular Modelling Studies on the Human Muscarinic M5 Receptor
"DPhG-Jahrestagung 2005"
05.10.-08.10.05, Mainz
N. Sonnenberg, P. Kleinebudde und H.-D. Höltje
Microcristalline Cellulose studied by Molecular Dynamics Simulations
"DPhG-Jahrestagung 2005"
05.10.-08.10.05, Mainz
Classen-Houben D., Sippl W., Höltje H.-D.
3D-QSAR and Virtual Screening of Protein-Tyrosine-Phosphatase 1B Inhibitors
Joint Meeting on Medicinal Chemistry (JMMC)
23.06.-26.06.05, Vienna
Originalarbeiten
C. Wittekindt, M. Böttger, H.-D. Höltje, M. Schäfer-Korting, R. Cartier und A. Haberland
Integrin-specificity of the cyclic Arg-Gly-Asp motif and its role in integrin targeted gene transfer
Biotechnol. Appl. Biochem. 40, 281-290 (2004)
S. Bendels und H.-D. Höltje
Comparison of a 3D-Model of the Classical a-Scorpion Toxin V from Leiurus quinquestriatus quinquestriatus with other Scorpion Toxins
Journal of Computer Aided Molecular Design 18, 119-133 (2004)
G.R. Stahl und H.-D. Höltje
Development of models of Cytochrome P450 2A5 and 2A6
Die Pharmazie 60, 247-253 (2005)
B. Schlegel, W. Sippl und H.-D. Höltje
Setting up a Simulation System for GPCR Homology Modelling
Proceedings of the QSAR2004 Symposium in Istanbul
C. Hensen, J.C. Hermann, K. Nam, S. Ma, J. Gao und H.-D. Höltje
A Combined QM/MM Approach to Protein-Ligand Interactions: Polarization Effects of the HIV-1 Protease on Selected High Affinity Inhibitors
J. Med. Chem. 27, 6673-6680 (2004)
Abstracts
K. Jöhren und H.-D. Höltje
Different environments for a realistic simulation of GPCRs - Application to the M2 muscarinic acetylcholine receptor
"Frontiers in Medicinal Chemistry"
15.03.-17.03.04, Erlangen
B. Bröer, M. Gurrath und H.-D. Höltje
Molecular Modelling Studies on the ORL1-Receptor and ORL1-Agonists
"Frontiers in Medicinal Chemistry"
15.03.-17.03.04, Erlangen
B. Schlegel, W.Sippl, H. Stark und H.-D. Höltje
Molecular Dynamics Simulations of Histamine H3Receptor/Ligand Complexes
"Frontiers in Medicinal Chemistry"
15.03.-17.03.04, Erlangen
B. Schlegel, W.Sippl, H. Stark und H.-D. Höltje
Molecular Dynamics Simulations of Histamine H3Receptor/Ligand Complexes
"Histamine Research Society"
28.04.-02.05.04, Düsseldorf
A. Hombrecher und H.-D. Höltje
Molecular Modelling Studies on the Human Cytochrome P450 1A2
"15th European Symposium on QSAR & Molecular Modelling"
05.09.-10.09.04, Istanbul, Türkei
C. Hensen, J.Gao und H.-D. Höltje
Determination of Polarization Effects of the HIV-1 Protease on Selected High Affinity Inhibitors for the Development of New Active Agents
"15th European Symposium on QSAR & Molecular Modelling"
05.09.-10.09.04, Istanbul, Türkei
G. Menche und H.-D. Höltje
Molecular Modelling Study of Enantiomeric Separation in HPLC
"15th European Symposium on QSAR & Molecular Modelling"
05.09.-10.09.04, Istanbul, Türkei
Originalarbeiten
M. Höltje und H.-D. Höltje
Applications of Quantum Chemical Methods in Drug Design
Medicinal Quantum Chemistry, Carloni and Alber, EDS, Wiley-VCH, (2003)
S. Hammer, I. Spika, W. Sippl, G. Jessen, B. Kleuser, H.-D. Höltje und M. Schäfer-Korting
Glucocorticoid Receptor Interactions with Glucocorticoids: Evaluation by Molecular Modeling and Functional Analysis of Glucocorticoid Receptor Mutants
Steroids, Vol.68: 329-339 (2003)
M. Langer, M. Höltje, N.A. Urbanetz, B. Brandt, H.-D. Höltje, B.C. Lippold
Investigations on the predictabilityof the information of glassy solid solutions of drugs in sugar alcohols
Int. J. Pharm. 252 : 167-179 (2003)
J. Hermann, L. Ridder, A. Mulholland, H.-D. Höltje
Identification of Glu166 as the General Base in the Acylation Reaction of Class A ß-Lactamases through QM/MM Modeling
J. Am. Chem. Soc. 125(32), 9590 (2003)
U. Voigtländer, A. Raasch, C. Tränkle, S. Buller, J. Ellis, K. Mohr, K. Jöhren , H.-D. Höltje
Allosteric site on muscarinic acetylcholine receptors: Identification of two amino acids selectives of some structurally diverse allosteric ligands
Mol. Pharmacol. 64, 21-31 (2003)
C. Anézo, A.H. de Vries, H.-D. Höltje, D. P. Tieleman, S.-J. Marrink
Methodological issues in lipid bilayer simulations
Journal of Physical Chemistry, 107, 9424-9433 (2003)
H.-D. Höltje, W. Sippl, D. Rognan, G.Folkers
Molecular Modeling
Basic Principles and Applications. 2nd Edition
Wiley-VCH, Heidelberg 2003
A. Hackling, R. Ghosh, S. Perachon, A. Mann, H.-D. Höltje, C.G. Wermuth,J.-C. Schwartz, W. Sippl, P. Solokoff, H. Stark
N-(w-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D2 und D3 Receptor Ligands
J. Med. Chem. 46, 38883-3899 (2003)
H.-D. Höltje
Pharmacophore Identification and Receptor Mapping
in: The Practice of Medicinal Chemistry; C. Wermuth, Editor
Elsevier Science Publ., Amsterdam 2003
B. Bröer, M. Gurrath und H.-D. Höltje
Molecular Modelling Studies on the ORL1-Receptor and ORL1-Agonists
Journal of Computer Aided Molecular Design 17, 739-754 (2003)
Abstracts
J. Hermann, L. Ridder, A. Mulholland, H.-D. Höltje
Investigations on the Acylation of Tem1 ß-Lactamase from E.Coli
"Computational Modelling of Catalysis, Symposium at the Max-Planck-Institut für Kohlenforschung"
Mühlheim a.d.Ruhr 2003
A. Vollbrecht, K.-J. Schleifer, H.-D. Höltje
Homology Model of L-Type Calcium Channels - Investigations on the Selectivity Filter and the Dihydropyridine Binding Site
"17. Darmstädter Molecular-Modelling-Workshop"
27.05.-28.05.03, Erlangen
D. Classen-Houben, W. Sippl, H.-D. Höltje
Development of Ligand based and receptor based 3D-QSAR Models of Protein-Tyrosin-Phosphatase 1B Inhibitors
"17. Darmstädter Molecular-Modelling-Workshop"
27.05.-28.05.03, Erlangen
D. Classen-Houben, W. Sippl, H.-D. Höltje
Entwicklung von ligand- und rezeptorbasierten 3D-QSAR Modellen für Protein-Tyrosin-Phosphatase 1B Inhibitoren
"Doktorandentagung der DPhG"
07.03.-08.03.03, Düsseldorf
Originalarbeiten
R. Ghosh und H.-D. Höltje
In Silico HTS for New Drug Candidates
CHEManager:Screening, Trends in Drug Discovery, Vol. 3,Feb. I/2002
U. Uhrig, H.-D. Höltje R. Mannhold, H. Weber, H. Lemoine
Molecular Modeling and QSAR studies on KATP channel openers of the Benzopyran Type
Journal of Molecular Graphics and Modelling 21, 37-45 (2002)
M. Iadanza, M. Höltje, G. Ronsisvalle und H.-D. Höltje
A k-Opiood Receptor Model in a phospholipid Bilayer: Molecular Dynamics Simulation
Journal of Medicinal Chemistry 45, 4838-4846 (2002)
H.-D. Höltje, F. Stoll, R. Ghosh, G. Stahl und M. Höltje
New Methods in Drug Research
Pharm. Ind. 64, 8a, 838-844 (2002)
M. Pastor, P. Benedetti, A. Carotti, C. Diaz, C. Herraiz, H.-D. Höltje, M.I. Loza, T. Oprea, F. Padin, F. Pubill, F. Sanz, F. Stoll and the LINK3D Consortium
DISTANT COLLABORATION IN DRUG DISCOVERY: THE LINK3D PROJECT
Journal of Computer Aided Molecular Design 16, 809 - 818 (2002)
M.L. Barreca, J. Balzarini, A. Chimirri, E. De Clercq, L. De Luca, H.-D. Höltje, M. Höltje, A.M. Monforte, P. Monforte, C. Pannecouque, A. Rao and M. Zapallà
Design, Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies of 2,3-Diaryl-1,3-thiazolidin-4-ones as Potent Anti-HIV Agents
J. Med. Chem. 45, 5410-5413 (2002)
F. Stoll, S. Liesener, T. Hohlfeld, K. Schrör, P.L. Fuchs, H.-D. Höltje
Pharmacophore Definition and Three-Dimensional Quantitative Structure-Activity Relationship Study on Structurally Diverse Prostacyclin Receptor Agonists
Mol. Pharmacol 62, 1103-1111 (2002)
K. Jöhren and H.-D. Höltje
A model of the human M2 muscarinic acetylcholine receptor
Journal of Computer Aided Molecular Design 16,795-801 (2002)
Abstracts
K. Jöhren und H.-D. Höltje
MODELLING AN ALLOSTERIC BINDING SITE OF THE M2 MUSCARINIC ACETYLCHOLINE RECEPTOR
"Dissecting G-Protein-Coupled Receptors: Structure, Function, and Ligand Iteraction" / Wiesbaden
24.-26. Januar 2002
B. Bröer, M. Gurrath und H.-D. Höltje
Molecular Modelling Studies on the ORL1-Receptor
"Dissecting G-Protein-Coupled Receptors: Structure, Function, and Ligand Iteraction" / Wiesbaden
24.-26. Januar 2002
R. Ghosh, A. Hackling, W. Sippl, H. Stark und H.-D. Höltje
Molecular Modelling Studies on Dopamine D3 Receptor Ligands "Dissecting G-Protein-Coupled Receptors: Structure, Function, and Ligand Iteraction" / Wiesbaden
24.-26. Januar 2002
B. Bröer, M. Gurrath und H.-D. Höltje
Molecular Modelling Studies on the ORL1-Receptor
"European Graduate Student Meeting"
8.-10.2.02, Frankfurt/Main
C. Hensen und H.-D. Höltje
Computational Investigations of Aspartyl Protease Inhibitors
"European Graduate Student Meeting"
8.-10.2.02, Frankfurt/Main
A. Hombrecher und H.-D. Höltje
Prediction of Drug Lipophilicities based on Molecular Dynamics SSimulations
"European Graduate Student Meeting"
8.-10.2.02, Frankfurt/Main
G. Menche und H.-D. Höltje
Molecular Modelling Study on Chiral Discrimination in HPLC
"European Graduate Student Meeting"
8.-10.2.02, Frankfurt/Main
S. Hammer, I. Spika, G. Jessen, H.-D. Höltje,M. Schäfer-Korting
Glucocorticoid-Receptor Interactions: Evaluation by Molecular Modeling and Transactivation of Wild Type and Mutant Receptors
"43. Frühjahrstagung der DGPT"
12.3.-14.3.02, Mainz
A. Vollbrecht, K.-J. Schleifer und H.-D. Höltje
1,4Dihydropyridine und Calciumkanäle: eine Molecular Modelling Studie
"Spring-Symposium of the GDCh-JungChemikerForum"
13.3.-15.3.02, Aachen
D. Classen-Houben, W. Sippl und H.-D. Höltje
Molecular Modelling Untersuchungen von Ligand/Rezeptor-Komplexen der Protein-Tyrosin-Phosphatase 1B
"Spring-Symposium of the GDCh-JungChemikerForum"
13.3.-15.3.02, Aachen
D. Classen-Houben, W. Sippl und H.-D. Höltje
Molecular Modelling Untersuchungen von Ligand/Rezeptor-Komplexen der Protein-Tyrosin-Phosphatase 1B
"16. Darmstädter Molecular-Modelling-Workshop"
07.5.-08.5.02, Darmstadt
A. Hombrecher und H.-D. Höltje
Prediction of Drug Lipophilicities based on Molecular Dynamics SSimulations
"16. Darmstädter Molecular-Modelling-Workshop"
07.5.-08.5.02, Darmstadt
A. Vollbrecht, K.-J. Schleifer und H.-D. Höltje
1,4-Dihydropyridine und Calciumkanäle: eine Molecular Modelling Studie
"16. Darmstädter Molecular-Modelling-Workshop"
07.5.-08.5.02, Darmstadt
B. Rupp und H.-D.Höltje
Molecular dynamics simulation on insuline-dimer dissociation in aqueous environment
"International Symposium of the Volkswagenstiftung on "Isolated Molecules of Biological Interest"
Schloß Mickeln, Düsseldorf
27. Juni bis 1 Juli, 2001
B. Rupp und H.-D. Höltje
Molekül-Dynamische Studien zum Zerfall von Human-Insulin und Lys/Pro-Insulin-Dimeren
"16. Darmstädter Molecular-Modelling-Workshop"
07.5.-08.5.02, Darmstadt
K. Jöhren und H.-D. Höltje
Modelling an allosteric binding site of the M2 muscarinic acetylcholine receptor
"17th International Symposium on Medicinal Chemistry"
01.09.-05.09.
B. Bröer, M.Gurrath und H.-D. Höltje
Molecular Modelling Studies on the ORL1-Receptor
"17th International Symposium on Medicinal Chemistry"
01.09.-05.09.
J. Hermann und H.-D. Höltje
Computational Investigations on the Acylation of TEM1 Beta-Lactamase from E.Coli
"DPHG Jahrestagung Berlin 2002"
10.10.-12.10.
C. Hensen und H.-D. Höltje
Theoretical Investigations of Aspartyl Protease Inhibitors
"DPhG-Jahrestagung Berlin 2002"
10.10.-12.10.
S. Karkola, K. Wähälä, M. Höltje, H.-D. Höltje
Molecular Modeling of Aromatase using CYP2C5 as template Structure
"Int. Congress on Hormonal Steroids and Hormones and Cancer 2002"
21.10.-25.10. Fukuoka, Japan
Originalarbeiten
M. Höltje, Th. Förster, B. Brandt, Th. Engels, W. von Rybinsky und H.-D. Höltje
Molecular dynamics simulations of stratum corneum lipid models:
fatty acids and cholesterol
Biochimica et Biophysica Acta 1511 156-167 (2001)
A. Schappach und H.-D. Höltje
Investigations on inhibitors of human 17a-hydroxylase-17, 20-lyase and their interactions with the enzyme
Die Pharmazie 56, (11) 835-842 (2001)
M.U. Adikwu und H.-D. Höltje
Mechanistic apraisal of the charge-transfer complexes of promethazine with chloranil: A modelling approach
CHEM PHARM BULL 49: (6) 669-674 (2001)
H.-D. Höltje
Die Anwendung von Molecular-Modelling-Methoden in der Arzneistoffforschung
PZ Prisma Nr. 4, 217-227, 8. Jahrgang (2001)
W.Sippl und H.-D. Höltje
Rational Approaches to Drug Design
13th European Symposium on QSAR
Prous Science (2001)
Abstracts
O. Salo, H.-D. Höltje, M. Höltje und K.-J. Schleifer
Molecular Modelling of Human Peripheral Cannabinoid Receptor (CB 2) Ligands
3rd European Graduate Student Meeting der DPhG
Frankfurt, 23.02. - 25.02.2001
A. Vollbrecht, H.-D. Höltje und K.-J. Schleifer
Modelling the Dihydropyridine Binding Site
3rd European Graduate Student Meeting der DPhG
Frankfurt, 23.02. - 25.02.2001
D. Claßen-Houben, H.-D. Höltje, K.-J. Schleifer und W. Sippl
Molecular Modelling and 3D-QSAR Studies of Tyrosine Phosphate 1B Inhibitors
3rd European Graduate Student Meeting der DPhG
Frankfurt, 23.02. - 25.02.2001
J. Hermann und H.-D. Höltje
Computational Investigations on Penicillin Binding Proteins
3rd European Graduate Student Meeting der DPhG
Frankfurt, 23.02. - 25.02.2001
K. Jöhren und H.-D. Höltje
Modelling an Allosteric Binding Site of the M2 Muscarinic Acetylcholine Receptor
3rd European Graduate Student Meeting der DPhG
Frankfurt, 23.02. - 25.02.2001
D. Claßen-Houben, H.-D. Höltje, K.-J. Schleifer und W. Sippl
3D-QSAR und Docking Untersuchungen an Protein-Tyrosin-Phosphatase 1B Inhibitoren
15. Darmstädter Molecular Modelling Workshop
22.-23. Mai 2001
K. Jöhren und H.-D. Höltje
Theoretische Überlegungen zu einer allosterischen Bindungsstelle des M2 Acetylcholin-Rezeptors
15. Darmstädter Molecular Modelling Workshop
22.-23. Mai 2001
J. Hermann und H.-D. Höltje
Theoretische Untersuchungen an Penicillin-Bindenden-Proteinen
15. Darmstädter Molecular Modelling Workshop
22.-23. Mai 2001
A. Vollbrecht, K.-J. Schleifer und H.-D. Hölltje
Modellierung der Dihydropyridin-Bindungstelle
15. Darmstädter Molecular Modelling Workshop
22.-23. Mai 2001
J.Hermann, L.Ridder, A.J. Mulholland und H.-D. Höltje
Computational Investigations on the Acylation of TEM1 Beta-Lactamase from E.Coli
"Model(l)ing 2001", Erlangen, September 16-21, 2001
F. Stoll und H.-D. Höltje
A model of the Prostacyclin Receptor
"Model(l)ing 2001", Erlangen, September 16-21, 2001
G. Stahl und H.-D. Höltje
Development of a Cytochrome P450 2A5 model
"Model(l)ing 2001", Erlangen, September 16-21, 2001
R. Ghosh, W. Sippl, H. Stark und H.-D. Höltje
Molecular Modelling Studies on Dopamine D3 Receptor Ligands
"Model(l)ing 2001", Erlangen, September 16-21, 2001
Originalarbeiten
W. Sippl and H.-D. Höltje
Structure-based 3D-QSAR-merging the accuracy of structure-based alignments with the
computational efficiency of ligand-based methods
Journal of Molecular Structure: Theochem, 503, 31-50, (2000)
W. Sippl
Receptor-based 3D QSAR analysis of estrogen receptor ligands – merging the accuracy of
receptor-based alignments with the computational efficiency of ligand-based methods
Journal of Computer-Aided Molecular Design 14, 559-572, (2000)
P.A.M. van Hooft and H.-D. Höltje
Construction of a full three-dimensional model of the transpeptidase domain of
Streptococcus pneumoniae PBP2x starting from Ca-atom coordinates
Journal of Computer-Aided Molecular Design 14) 719-730 (2000
N. Cinone, H.-D. Höltje and A. Carotti
Development of a unique 3D interaction model of endogenous and synthetic
peripheral benzodiazepine receptor ligands
Journal of Computer-Aided Molecular Design 14 753-768 (2000)
A. Schappach and H.-D. Höltje
Molecular modelling of 17a-hydroxylase-17, 20-lyase
Die Pharmazie 56, (6)435-442 (2001)
J.M. Contreras, I. Parrot, W. Sippl, Y.M. Rival and C.G. Wermuth
Design, Synthesis and Structure-Activity Relationships of a series of
3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives
as Acetylcholinesterase Inhibitors
J. Med. Chem., submitted, (2000)
W. Sippl, J.M. Contreras, I. Parrot, Y.M. Rival and C.G. Wermuth
Receptor-based 3-QSAR analyis of novel acetylcholinesterase inhibitors
Journal of Computer-Aided Molecular Design, submitted, (2000)
Abstracts
R.Ghosh, W.Sippl, H.Stark, H.-D. Höltje
3-D-QSAR Untersuchungen neuartiger Dopamin D3-Rezeptorliganden
14. Darmstädter Molecular-Modelling Workshop
30.-31. Mai 2000
A. Holz, M. Gurrath, H.-D. Höltje
Auf der Suche nach einer Bindungsstelle fuer nichtpeptidische Bradykinin B2-Rezeptorantagonisten
14. Darmstädter Molecular Modelling Workshop
30.-31. Mai 2000
F. Stoll und H.-D. Höltje
Ein Modell des Prostacyclin-Rezeptors
14. Darmstädter Molecular Modelling Workshop
30.-31. Mai 2000
G. Stahl und H.-D. Höltje
Entwicklung eines Cytochrom P450 2A5 Modells
14. Darmstädter Molecular-Modelling Workshop
30.-31. Mai 2000
S.Bendels und H.-D. Höltje
Dynamiksimultation von Delta-Atracotoxin-Ar1
14. Darmstädter Molecular Modelling Workshop
30.-31. Mai 2000
S.Buchwald-Werner und H.-D. Höltje
Computational Study for Chiral Discrimination on Quinine-based Chiral Stationary Phase
Corso Avavzato in Chimica Farmaceutica e Seminario Nazionale Dottorandi "E Duranti"
Urbino/Italien
03-07.07.2000
W. Sippl
Receptor-Based 3D-QSAR - Merging the Accuracy of Receptor-Based Alignments with the Computational Efficiency of Ligand-Based Methods
13th European Symposium on Quantitative Structure-Activity Relationships
Düsseldorf, 27.08. - 01.09.2000
Abstract-Book, P.119
W. Sippl, J.M. Contreras, Y. Rival and C.G. Wermuth
Structure Based 3D-QSAR Studies of Novel Acetylcholinesterase Inhibitors
13th European Symposium on Quantitative Structure-Activity Relationships
Düsseldorf, 27.08. - 01.09.2000
Abstract-Book, P.2
R. Ghosh, W. Sippl, H. Stark and H.-D. Höltje
Virtual Sreening based on Dopamine D3-Receptor Ligands
13th European Symposium on Quantitative Structure-Activity Relationships
Düsseldorf, 27.08. - 01.09.2000
Abstract-Book, P.133
A. Holz, M. Gurrath, H.-D. Höltje
In search of a binding site for non-peptide bradykinin B2 receptor antagonists
13th European Symposium on quantitative structure-activity realtionships
Duesseldorf, 27. August - 1. September 2000
C. Anezo and H.-D. Höltje
Permeation Process of Active Substances across Phospholipid Membranes by
Molecular Dynamics Simulations
13th European Symposium on Quantitative Structure-Activity Relationships
Düsseldorf, 27.08. - 01.09.2000
Abstract-Book, P.104
G. Stahl und H.-D. Höltje
Development of a Cytochrome P450 2A5 model
13th European Symposium on Quantitative Structure-Activity Relationships
Düsseldorf, 27.08. - 01.09.2000
Abstract-Book, P.18
S.Bendels und H.-D. Höltje
Dynamiksimultation von Delta-Atracotoxin-Ar1
13th European Symposium on Quantitative Structure-Activity Relationships
Düsseldorf, 27.08. - 01.09.2000
S.Buchwald-Werner und H.-D. Höltje
Computational Study for Chiral Discrimination on Quinine-based Chiral Stationary Phase
13th European Symposium on Quantitative Structure-Activity Relationships
Düsseldorf, 27.08. - 01.09.2000
S.Buchwald-Werner und H.-D. Höltje
Computational Study for Chiral Discrimination on Quinine-based Chiral Stationary Phase
Chirality 2000, Chamonix/Frankreich
24-28.09.2000
R. Ghosh, W. Sippl, H. Stark and H.-D. Höltje
3D-QSAR and Virtual Sreening of Dopamine D3-Receptor Ligands
Jahrestagung der Deutschen Pharmazeutischen Gesellschaft (DPhG 2000)
Münster, 05.10. - 07.10.2000
W. Sippl, J.M. Contreras, Y. Rival and C.G. Wermuth
Struktur-basiertes Design neuer Acetylcholinesterase Inhibitoren für die Therapie der Alzheimerschen Krankheit
Fachgruppentagung der Deutschen Pharmazeutischen Gesellschaft (DPhG 2000)
Hamburg, 28.02.2000
W. Sippl
Receptor-based 3D-QSAR - Application on Estrogen Receptor Ligands and Acetylcholinesterase Inhibitors
Jahrestagung der Deutschen Pharmazeutischen Gesellschaft (DPhG 2000)
Münster, 05.10. - 07.10.2000
A. Holz, M. Gurrath, H.-D. Höltje
Auf der Suche nach einer Bindungsstelle fuer nichtpeptidische Bradykinin B2-Rezeptorantagonisten
Jahrestagung der Deutschen Pharmazeutischen Gesellschaft (DPhG 2000)
Münster, 05.10. - 07.10.2000
F. Stoll und H.-D. Höltje
A Prostacyclin Receptor Modell
Jahrestagung der Deutschen Pharmazeutischen Gesellschaft (DPhG 2000)
Münster, 05.10. - 07.10.2000
G. Stahl und H.-D. Höltje
Entwicklung eines Cytochrom P450 2A5 Modells
Jahrestagung der Deutschen Pharmazeutischen Gesellschaft (DPhG 2000)
Münster, 05.10. - 07.10.2000
S.Bendels und H.-D. Höltje
Dynamiksimultation von Delta-Atracotoxin-Ar1
Jahrestagung der Deutschen Pharmazeutischen Gesellschaft (DPhG 2000)
Münster, 05.10. - 07.10.2000
S.Buchwald-Werner und H.-D. Höltje
Computational Study for Chiral Discrimination on Quinine-based Chiral Stationary Phase
Jahrestagung der Deutschen Pharmazeutischen Gesellschaft (DPhG 2000)
Münster, 05.10. - 07.10.2000
Bücher und Buchbeiträge
H. Auterhoff, J. Knabe und H.-D. Höltje.
Lehrbuch der Pharmazeutischen Chemie, 14. Auflage.
Wissenschaftliche Verlagsgesellschaft mbH Stuttgart (1999)
Originalarbeiten
H. Lemoine, H. Weber, A. Derix, U. Uhrig, R. Mannhold, H.-D. Höltje
6-varied benzopyrans: vasorelexant activity in rat aorta and trachea, structure activity relationship, conversion to muscarinic antagonists
European Journal of Pharmacology 378, 85-97 (1999)
A. Gysler, B. Kleuser, W. Sippl, K. Lange, H.C. Korting, H.-D. Höltje, M. Schäfer-Korting
Differential Skin Penetration and Metabolism of Topical Glucocorticoids contributes to the Increased Benefit/Risk Ratio of Prednicarbate
Pharm. Res. 16, 1386-1391 (1999)
Abstracts
R. Ghosh, W. Sippl, H. Stark and H.-D. Höltje.
Molecular Modelling and 3D-QSAR Studies of Dopamine D3-Receptor
Antagonists 12th Camerino Noordwijkerhout Symposium Perspectives in Receptor Research,
Camerino/Italien,
5.-9.9.1999.
Abstract-Book S. 116
Holz A., Gurrath M., Hoeltje H.D.
Pharmacophore Model of Non-Peptide Bradykinin B2-Receptor Antagonists
DoktorandInnentagung 1999 Freiburg i.Br.
11.-13.03.1999
Arch. Pharm. Pharm. Med. Chem. 331, Suppl. 1, 35, (1999)
S. Buchwald-Werner and H.-D. Höltje
Computational Study on the Importance of pi-pi Interaction for Chiral Discrimination
DoktorandInnentagung 1999 Freiburg i.Br.
11.-13.03.1999
Arch. Pharm. Pharm. Med. Chem. 331, Suppl. 1, 30, (1999)
S. Bendels and H.-D. Höltje
Three-dimensional Model of the sodium channel-specific neurotoxin Lqq V
DoktorandInnentagung 1999 Freiburg i.Br.
11.-13.03.1999
Arch. Pharm. Pharm. Med. Chem. 331, Suppl. 1, 29, (1999)
W. Sippl, J.M. Contreras, Y. Rival and C.G. Wermuth
Struktur-basierte 3D QSAR Analyse neuer Acetylcholinesterase Inhibitoren
Jahrestagung der Östereichischen Pharmazeutischen Gesellschaft (ÖPhG 1999)
Innsbruck, 1.10.1999
Bücher und Buchbeiträge
M. Gurrath, G. Müller and H.-D. Höltje
Pseudoreceptor Modeling in Indirect Drug Design: Application of Yak and Prgen
in H. Kubinyi, G. Folkers and Y. Martin (Eds.): 3D-QSAR in Drug Design, Vol. III.
Kluwer Academic Publ., Perspectives in Drug Discovery and Design, 12/13/14: 135-157 (1998)
Originalarbeiten
H.-D. Höltje und G. Jessen
Mibefradil und Verapamil im Strukturvergleich
Pharmazeutische Zeitung 1/2, 40-41 (1998)
H.-D. Höltje and C. Fattorusso
Construction of a model of the Candida albicans lanosterol 14-alpha demethylase active site using the Homology Modelling
Pharmaceutica Acta Helvetica 72, 271-277 (1998)
H.-D. Höltje und G. Jessen
Warum Lispro-Insulin rasch verfügbar ist
Pharmazeutische Zeitung 20, 52-53 (1998)
T. Beier and H.-D. Höltje
Modified Cyclodextrines as Chiral Selcectors: Molecular Modelling Investigations on the Enantioselective Binding Properties of Heptakis(2,3-di-O-methyl-6-O-tert.- butyldimethylsilyl)-b-cyclodextrin
J. Chromatogr. B, 708, 1-20 (1998)
K. Gaedt and H.-D. Höltje
Consistent Valence Force Field parametrization of bond lengths and angles with quantum chemical ab inito mehtods applied to some heterocyclic dopamine D3 -receptor agonists
J. Comp. Chem., Vol. 19, No. 8, 935-946 (1998)
W. Sippl, H. Stark and H.-D. Höltje
Development of a Binding Site Model for Histamine H3-Receptor Agonists
Die Pharmazie 53, 433-437 (1998)
K.-J. Schleifer, E. Tot and H.-D. Höltje
Pharmacophore and Pseudoreceptor Modelling of Class Ib Antiarrhytmic and Local Anaesthetic Lidocaine Analogues
Die Pharmazie 53, 596-602 (1998)
V. Kettmann and H.-D. Höltje
Mapping of the Benzothiazepine Binding Site on the Calcium Channel
QSAR 17, 91-101 (1998)
K.-J. Schleifer and H.-D. Höltje
Molecular modelling investigation of wild-type and the Arg528His mutated segment
4 of human L-type voltage-gated calcium channels,
Protein Engineering, 11, 1033-1040 (1998)
Abstracts
K.-J. Schleifer and H.-D. Höltje
3D-QSAR of Calcium Channel Blocking 1,4-Dihydropyridines - A Pseudoreceptor Modelling Study
Abstract Book S. 54, P30.
C. Kirchhoff, K.-J. Schleifer and H.-D. Höltje
beta-Turn Mimetics as Potential Candidates for Lead Finding - A Unrestraint Molecular Dynamics Simulation Approach of Peptide beta-Turns
Abstract Book S. 43, P19.
M. Gurrath, H.-D. Höltje, G. Müller
Peptide-Binding GPCRs: From Sequence to Structure.
IBC's Fourth Annual International Conference on G Protein-Coupled Receptors:
Therapeutic Advancements and Applications, Orlando
5.-7.10. 1998
Abstract Book P5
Bücher und Buchbeiträge
H.-D. Höltje and W. Sippl
Molecular Modelling Studies on Histamine H2- and H3-Receptor Agonists
Proceedings of the XIV Symposium on Medicinal Chemistry, Maastricht, Netherlands
Elsevier Science Publ. Amsterdam, 137 (1997)
K.-J. Schleifer
Sekundaerstrukturvorhersagen an spannungsabhaengigen Calciumkanaelen
in Chemie und Informatik: Terra incognita oder das Land der unbegrenzten Möglichkeiten?
Ed.: B. Koppenhoefer und U. Epperlein.
Shaker Verlag Aachen, S. 149-157 (1997)
Originalarbeiten
H.-D. Höltje and M. Höltje
Struktur und Funktion von HIV-Protease-Hemmern
Pharmazeutische Zeitung 27, 31-38 (1997)
H.-D. Höltje, G. Jessen, M. Höltje
The Development of Nonpeptide Angiotensin II Receptor Antagonis:
A Success Story
Die Pharmazie 52, 83-86 (1997)
K.-J. Schleifer
Comparative Molecular Modeling Study of the Calcium Channel Blockers Nifedipine and Black Mamba Toxin FS2
J. Comp.-Aided Mol. Design 11, 491-501 (1997)
K.-J. Schleifer
Spannungsabhaengiger L-Typ Calciumkanal-Aufbau, Funktion und Modulation
Pharm. Unserer Zeit 4, 179-186 (1997)
Abstracts
K.-J. Schleifer.
Modelle zum molekularen Bindungsverhalten von calciumantagonistisch wirksamen 1,4-Dihydropyridinen Fachgruppentagung der Fachgruppe Pharmazeutische Chemie der DPhG, Wuerzburg
10.-12.3.1997
Abstract Book P4
G. Müller, M. Gurrath and H.-D. Höltje.
Molecular Dynamic Simulatiuons on G-Protein Coupled Receptors-I:
Implementation and Validation of a Membrane Mimetic
Second International Conference on Molecular Structural Biology, Wien
8.-10.9.1997
M. Gurrath, G. Müller and H.-D. Höltje.
Molecular Dynamic Simulatiuons on G-Protein Coupled Receptors-II:
Application on Bacteriorhodopsin and CCK-B Receptor Complexes
Second International Conference on Molecular Structural Biology, Wien
8.-10.9.1997
U. Uhrig and H.-D. Höltje.
Molecular Modelling Study on K(ATP)-Channel Openers
Jahreskongress 1997 der DPhG und der SGPhW, Zuerich
3.-5.10.1997
K.-J. Schleifer and H.-D. Höltje.
Pseudoreceptor Modelling of Calcium Channel Blocking 1,4-Dihydropzridines
Jahreskongress 1997 der DPhG und der SGPhW, Zuerich
3.-5.10.1997
C. Kirchhoff, K.-J. Schleifer and H.-D. Höltje.
Molecular Dynamics Simulation of beta-Turns
Jahreskongress 1997 der DPhG und der SGPhW, Zuerich
3.-5.10.1997
A. Schappach and H.-D. Höltje.
Molecular Modelling Studies on Steroid Hydroxylating Enzymes of Therapeutical Relevance
Jahreskongress 1997 der DPhG und der SGPhW, Zuerich
3.-5.10.1997
J.M. Contreras, S. Chair, W. Sippl, P. Guilbaud, Y. Rival, J.C. Bourguignon and C.G. Wermuth
Inhibiteur de l'acetylcholinesterase derivees du donezepil
12. GESA 27 (Groupe d'Etudes Structure-Activite) Biaritz, Frankreich
12.10-15.10.1997
Bücher und Buchbeiträge
H.-D. Höltje and G. Folkers.
Molecular Modeling - Basic Principles and Applications
Volume 5 of Methods and Principles in Medicinal Chemistry
VCH Publisher, Inc., New York (1996)
H.-D. Höltje in: The Practice of Medicinal Chemistry,
Part V. Spatial Organization, Receptor Mapping and Molecular Modelling
Pharmacophore Identification and Receptor Mapping
C.G. Wermuth (Ed.), Academic Press San Diego, 437-457 (1996)
H.-D. Höltje und K. Kemmritz in:
Trends in QSAR and Molecular Modelling: Concepts, Computational Tools and Biological Applications. Molecular Modelling of the Heme Environment of Human Prostaglandin Endoperoxide Synthase 1: Comparison with the Crystal Structure.
J.R. Prous Science Publishers, Barcelona, P. 549-555 (1996)
Originalarbeiten
H.-D. Höltje und K. Stahl.
Struktur von Formestan und Testosteron
Pharm. Ztg. 45, 4 (1996)
H.-D. Höltje, T. Reda and H. Hermel
Compression/Expansion Hysteresis of Poly-L-Glutamic Acid Monolayers Spread at the Air/Water Interface
Langmuir 12, 6452-6458 (1996)
Abstracts
W. Sippl and H.-D. Höltje.
The Histamine H3-Receptor Agonist Binding Site - A Theoretical Study
11th European Symposium on Quantitative Structure-Activity Relationships, Lausanne, Switzerland
1.-6.9.1996
Abstract-Book S. P-39.D
K. Gaedt and H.-D. Höltje.
Molecular Modelling Study on D2- and D3Receptor Agonists
11th European Symposium on Quantitative Structure-Activity Relationships, Lausanne, Switzerland
1.-6.9.1996
Abstract-Book S. P-22.D
U. Uhrig and H.-D. Höltje.
Molecular Modelling Study on K(ATP)-Channel Openers
11th European Symposium on Quantitative Structure-Activity Relationships, Lausanne, Switzerland
1.-6.9.1996
Abstract-Book S. P-23.D
T. Beier and H.-D. Höltje.
A Molecular Modelling Study on Enantiodifferentiation using Modified Cyclodextrins
11th European Symposium on Quantitative Structure-Activity Relationships, Lausanne, Switzerland
1.-6.9.1996
Abstract-Book S. P-41.D
K.-J. Schleifer.
Molecular Modelling Investigation of Calcium Channel Blocking 1,4-Dihydropyridines an Toxin FS2 from Venom of Black Mamba
11th European Symposium on Quantitative Structure-Activity Relationships, Lausanne, Switzerland
1.-6.9.1996
Abstract-Book S. P-2.D
W. Sippl and H.-D. Höltje.
Molecular Modelling Studies on Histamine Receptor Agonists
G-Protein Coupled Receptor Symposium, Beerse, Belgium
20.-22.10.1996
Abstract-Book S. 48
K. Gaedt and H.-D. Höltje.
Molecular Modelling Study on D2- and D3Receptor Agonists
G-Protein Coupled Receptor Symposium, Beerse, Belgium
20.-22.10.1996
Abstract-Book S. 17
Originalarbeiten
W. Sippl, H. Stark and H.-D. Höltje.
Computer-Assisted Analysis of Histamine H2- and H3-Receptor Agonists.
Quant. Struct-Act. Relat. (QSAR) 14, 121-125 (1995).
H.-D. Höltje und K. Stahl.
Struktur von Finasterid und Testosteron.
Pharm. Ztg. 24. 50 (1995).
H.-D. Höltje und K. Stahl.
Levocabastin: Formel im Vergleich.
Pharm. Ztg. 28, 36 (1995).
H.-D. Höltje und K. Stahl.
Struktur von Risperidon, Dopamin und Serotonin.
Pharm. Ztg. 29, 32 (1995).
H.-D. Höltje und K. Stahl.
Pantoprazol ist säurestabiler.
Pharm. Ztg. 32, 29-32 (1995).
H.-D. Höltje and U. K. Jendretzki.
Construction of a detailed serotoninergic 5-HT2a receptor model.
Arch. Pharm. - Pharm. Med. Chem. 328, 577-584 (1995).
M. N. Romanelli, H.-D. Höltje and S. Scapecchi.
Theoretical Investigations on Antimuscarinic Ethylthio and Ethoxy Derivatives of Adiphenine and 4-DAMP.
Quant. Struct.-Act. Relat. (QSAR) 14, 126-143 (1995).
H. Hermel, H.-D. Höltje, S. Bergemann, U. De Rossi and J. Kriwanek.
Band-shifting through Polypeptide -sheet Structures in the Cyanine UV/VIS Spectrum.
Biochimica et Biophysica Acta (BBA) 1252, 79-86 (1995).
W. Brandt, C. Mrestani-Klaus, H. Schinke, K. Neubert, A. Barth, R. Schmidt, P.W. Schiller and H.-D. Höltje.
The Opioid Receptor Binding Pharmacophore Conformation of Ornithine Containing Cyclic ßCasomorphin Analogues and Related Peptides.
Quant. Struct.-Act. Relat. (QSAR) 14, 417-426 (1995).
Abstracts
W. Sippl and H.-D. Höltje.
Molecular Modelling Studies on Histamine H2- and H3-Receptor Agonists.
10th Camerino Noordwijkerhout Symposium Perspectives in Receptor Research, Camerino/Italien, 10.-14.9.1995.
Abstract-Book S. 183.
Th. Beier and H.-D. Höltje.
Modified Cyclodextrins as Chiral Selectors - A Molecular Modelling Study.
9. Darmstädter Molecular-Modelling Workshop, TH Darmstadt, 23.-24.5.1995.
Abstract-Book S. 24.
K. Gaedt and H.-D. Höltje.
Generation of Specific Dopamine D2- and D3-Pharmacophores - A Molecular Modelling Study.
10th Camerino Noordwijkerhout Symposium Perspectives in Receptor Research, Camerino/Italien, 10.-14.9.1995.
Abstract-Book S. 133.
Bücher und Buchbeiträge
H. Auterhoff, J. Knabe und H.-D. Höltje.
Lehrbuch der Pharmazeutischen Chemie, 13. Auflage.
Wissenschaftliche Verlagsgesellschaft mbH Stuttgart (1994)
W. Brandt, A. Barth und H.-D. Höltje.
Investigations of Structure-Activity Relationships of ß-Casomorphins and Further Opioids Using Methods of Molecular Graphics.
In: ß-Casomorphins and Related Peptides: Recent Developments, V. Brantl and H. Teschemacher (Eds.), VCH Weinheim, 93-105 (1994)
Originalarbeiten
H.-D. Höltje und K. Stahl.
Molecular-Modelling bei Antidepressiva.
Pharm. Ztg. 3, 39-40 (1994).
H.-D. Höltje.
Wirkungsmechanismen von Crataegus-Inhaltsstoffen.
Münchener Medizinische Wochenschrift 136, Suppl. 1, 61-63 (1994).
U. K. Jendretzki, S. Elz and H.-D. Höltje.
Computer aided molecular analysis of 5-HT2a agonists.
Pharm Pharmacol Lett 3, 260-263 (1994).
H. Kerckhoff and H.-D. Höltje.
Conformational analysis and receptor modelling of m1 and m2 selective antagonists.
Die Pharmazie 49, 566-573 (1994).
Abstracts
W. Sippl und H.-D. Höltje.
Konformationsanalyse und Untersuchung des molekularen elektrostatischen Potentials von Histamin H2-Rezeptor Agonisten.
8. Darmstädter Molecular-Modelling Workshop, TH Darmstadt, 10.-11. 5.1994.
Abstract-Book S. 37.
W. Sippl und H.-D. Höltje.
Sterical and Electronical Properties of Histamine H2-Receptor Agonists - A Molecular Modelling Study.
TRIPOS User Meeting, Dresden, 20.-21.9. 1994.
Abstract-Book S. 3.
W. Sippl and H.-D. Höltje.
Sterical and Electronical Properties of Histamine H2-Receptor Agonists.
2nd European Congress of Pharmaceutical Sciences, Berlin, 29.9.-1.10.1994.
European Journal of Pharmaceutical Sciences 2, 139 (1994).
Th. Beier and H.-D. Höltje.
A Molecular Modelling Study on Host-Guest Complex Formation in Modified Cyclodextrins.
2nd European Congress of Pharmaceutical Sciences, Berlin, 29.9.-1.10.1994.
European Journal of Pharmaceutical Sciences 2, 151 (1994).
M. Collmer and H.-D. Höltje.
What is the link between mambas and potassium channels?
2nd European Congress of Pharmaceutical Sciences, Berlin, 29.9.-1.10.1994.
European Journal of Pharmaceutical Sciences 2, 151 (1994).