Publications

2019     2018     2017     2016     2015     2014     2013     2012     2011    
2010     2009     2008     2007     2006     2005     2004     2003     2002     2001    
2000     vor 2000   


 

2019

     

  • R. Wiedey & P. Kleinebudde

    Potentials and limitations of thermography as an in-line tool for determining ribbon solid fraction.


    Powder Technol. 341 (2019) 2-10.

  • S. Grote, H. Osthues, F. Schaeffer & P. Kleinebudde

    The influence of isomalt particle morphology on tabletability after roll compaction/ dry granulation.


    Powder Technol. 341 (2019) 59-65.

  • H.L. Reimer & P. Kleinebudde

    Hybrid modeling of roll compaction processes with the Styl’One Evolution.


    Powder Technol. 341 (2019) 66-74.

  • P. Toson, D.G. Lopes, R. Paus, A. Kumar, J. Geens, S. Stibale, J. Quodbach, P. Kleinebudde, W.-K. Hsiao & J. Khinast

    Model-based approach to the design of pharmaceutical roller-compaction processes.


    Int. J. Pharm.: X 1 (2019) 100005.

  • J. Harting & P. Kleinebudde

    Optimisation of an in-line Raman spectroscopic method for continuous API quantification during twin-screw wet granulation.


    Eur. J. Pharm. Biopharm. 137 (2019) 77-85.

  • S. Grote & P. Kleinebudde

    A comparative study about the influence of alpha-lactose monohydrate particle morphology on granule and tablet properties after roll compaction/dry granulation.


    Pharm. Dev. Technol. 24 (2019) 314-322.

  • V. Pauli, F. Elbaz, P. Kleinebudde & M. Krumme

    Orthogonal redundant monitoring of a new continuous fluid-bed dryer for pharmaceutical processing by means of mass and energy balance calculations and spectroscopic techniques.


    J. Pharm. Sci. 108 (2019) 2041-2055.

  • V. Pauli, Y. Roggo, P. Kleinebudde & M. Krumme

    Real-time monitoring of particle size distribution in a continuous granulation and drying process by near infrared spectroscopy.


    Eur. J. Pharm. Biopharm. 141 (2019) 90-99.

  • P. Kleinebudde

    Trends in continuous manufacturing of pharmaceutical drug products.


    Pharm. Tech. Japan 35 (2019) 1175-1179.

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2018

     

  • R. Wiedey, R. Šibanc , A. Wilms & P. Kleinebudde

    How relevant is ribbon homogeneity in roll compaction/ dry granulation and can it be influenced?


    Eur. J. Pharm. Biopharm. 133 (2018) 232-239.

  • O.R. Arndt, R. Baggio, J. Harting, K. Adam, E. Franceschinis & P. Kleinebudde

    Impact of different dry and wet granulation techniques on granule and tablet properties: A comparative study.


    J. Pharm. Sci. 107 (2018) 3143-3152. Featured article December 2018.

  • S. Barimani & P. Kleinebudde

    In-line Raman spectroscopy monitoring of tablet coating processes with colored coatings.


    Talanta 178 (2018) 686-697.

  • G.F. Petrovick, P. Kleinebudde & J. Breitkreutz

    Orodispersible tablets containing taste-masked solid lipid pellets with metformin hydrochloride: Influence of process parameters on tablet properties.


    Eur. J. Pharm. Biopharm. 122 (2018) 137-145.

  • A. Lazzari, P. Kleinebudde & K. Knop

    Xanthan gum as rate-controlling polymer for the development of alcohol resistant matrix tablets and mini-tablets.


    Int. J. Pharm. 536 (2018) 440-449.

  • J. Harting & P. Kleinebudde

    Development of an in-line Raman spectroscopic method for continuous API quantification during twin-screw wet granulation.


    Eur. J. Pharm. Biopharm. 125 (2018) 169-181.

  • S. Barimani, R. Šibanc & P. Kleinebudde

    Optimisation of a semi-batch tablet coating process for a continuous manufacturing line by design of experiments.


    Int. J. Pharm. 539 (2018) 95-103.

  • S. Grote & P. Kleinebudde

    Roll compaction/ dry granulation of dibasic calcium phosphate anhydrous – Does the morphology of the raw material influence the tabletability of dry granules?


    J. Pharm. Sci. 107 (2018) 1104-1111.

  • H. Mangal & P. Kleinebudde

    Is the adjustment of the impeller speed a reliable attempt to influence granule size in continuous dry granulation?


    Adv. Powder Technol. 29 (2018) 1339-1347.

  • S. Grote & P. Kleinebudde

    Impact of functionalised particle structure on roll compaction/ dry granulation and tableting of calcium carbonate.


    Int. J. Pharm. 544 (2018) 235-241.

  • K. Csordás, R. Wiedey & P. Kleinebudde

    Impact of roll compaction design, process parameters and material deformation behaviour on ribbon relative density.


    Drug Dev. Ind. Pharm. 44 (2018) 1295-1306.

  • R. Wiedey, R. Šibanc & P. Kleinebudde

    Laser based thermo-conductometry as an approach to determine ribbon solid fraction off-line and in-line.


    Int. J. Pharm. 547 (2018) 330-337.

  • A. Schmidt, H. de Waard, K.-P. Moll, M. Krumme & P. Kleinebudde

    Continuous wet granulation with integrated in-barrel-drying.


    Pharm. Res. 35 (2018) 167.

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2017

     

  • T. Wenzel, C. Stillhart, P. Kleinebudde & A. Szepes

    Influence of drug load on dissolution behavior of tablets containing a poorly water-soluble drug: estimation of the percolation threshold.


    Drug Dev. Ind. Pharm. 43 (2017) 1265-1275.

  • S. Barimani & P. Kleinebudde

    Evaluation of in line Raman data for end-point determination of a coating process: Comparison of science based calibration, PLS-regression and univariate data analysis.


    Eur. J. Pharm. Biopharm. 119 (2017) 28-35.

  • A. Perez Gago & P. Kleinebudde

    MCC-mannitol mixtures after roll compaction/dry granulation: Percolation thresholds for ribbon microhardness and granule size distribution.


    Pharm. Dev. Technol. 22 (2017) 764-774.

  • R. Wiedey & P. Kleinebudde

    The density distribution in ribbons from roll compaction.


    Chem. Ing. Tech. 89 (2017) 1017-1024.

  • R. Meier, K.-P. Moll, M. Krumme & P. Kleinebudde

    Simplified, high drug-loaded formulations containing hydrochlorothiazide for twin-screw granulation.


    Chem. Ing. Tech. 89 (2017) 1025-1033.

  • C. Stomberg & P. Kleinebudde

    Development of a new dissolution test method for soft chewable dosage forms.


    AAPS PharmSciTech 18 (2017) 2446-2453.

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  • R. Meier, K.-P. Moll, M. Krumme & P. Kleinebudde

    How deformation behaviour controls product performance after twin-screw granulation.


    J. Pharm. Sci. 106 (2017) 291-301.
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  • E. Lenz, K. Löbmann, T. Rades, K. Knop & P. Kleinebudde

    Hot melt extrusion and spray drying of co-amorphous indomethacin-arginine with polymers.


    J. Pharm. Sci. 106 (2017) 302-312.
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  • P. Kazemi, M.H. Khalid, A. Perez Gago, P. Kleinebudde, R. Jachowicz, J. Szlęk, A. Mendyk

    Effect of roll compaction on granule size distribution of MCC-mannitol mixtures: computational intelligence modeling and parametric analysis.


    Drug Des. Dev. Ther. 11 (2017) 241-251.
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  • D. Hegyesi, M. Thommes, P. Kleinebudde, T. Sovány, P. Kása Jr., A. Kelemen, K. Pintye-Hódi & G. Regdon Jr.

    Preparation and physicochemical characterization of matrix pellets containing APIs with different solubility via extrusion process.


    Drug Dev. Ind. Pharm. 43 (2017) 458-464.
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  • J. Hisazumi & P. Kleinebudde

    In-line monitoring of multi-layered pellet film-coating using Raman spectroscopy by MCR and PLS analyses.


    Eur. J. Pharm. Biopharm. 114 (2017) 194-201.
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  • R. Meier, K.-P. Moll, M. Krumme & P. Kleinebudde

    Impact of fill-level in twin-screw granulation on critical quality attributes of granules and tablets.


    Eur. J. Pharm. Biopharm. 115 (2017) 102-112.
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  • H. Mangal & P. Kleinebudde

    Experimental determination of residence time distribution in continuous dry granulation.


    Int. J. Pharm. 524 (2017) 91-100.
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  • P. Boehling, G. Toschkoff, R. Dreu, S. Just, P. Kleinebudde, A. Funke, H. Rehbaum, J.G. Khinast

    Comparison of video analysis and simulations of a drum coating process.


    Eur. J. Pharm. Sci. 104 (2017) 72-81.
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  • R. Meier, J. Harting, J. Happel & P. Kleinebudde

    Implementation of microwave sensors in continuous powder feeding – a novel tool to bridge refill phases.


    Pharm. Ind. 79 (2017) 576-582.
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2016

     

  • K. Pongsamart, P. Kleinebudde & S. Puttipipatkhachorn
    Preparation of fenofibrate dry emulsion by using OSA starch as emulsifying agent and solid carrier.
    Int. J. Pharm. 498 (2016) 347-354
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  • D. Medarevic, P. Kleinebudde, K. Bekcic, Z. Djuric & S. Ibric

    Combined application of mixture experimental design and artificial neural networks in solid dispersion development.


    Drug Dev. Ind. Pharm. 42 (2016) 389-402.
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  • H. Mangal, M. Kirsolak & P. Kleinebudde

    Roll compaction/ dry granulation: Suitability of different binders

    Int. J. Pharm. 503 (2016) 213-219..

  • J. Kovacevic, S. Ibric, J. Djuris & P. Kleinebudde

    Application of design of experiments in optimization of drug layering of pellets with an insight into drug polymer interactions.

    Int. J. Pharm. 506 (2016) 312-319..

  • K. Tarp Jensen, L. Ingerslev Blaabjerg, E. Lenz, A. Bohr, H. Grohganz, P. Kleinebudde, T. Rades & K. Löbmann

    Preparation and characterization of spray-dried co-amorphous drug-amino acid salts.

    J. Pharm. Pharmacol. 68 (2016) 615-624..

  • P. Boehling, G. Toschkoff, S. Just, K. Knop, P. Kleinebudde, A. Funke, A. Altmeyer, D. Djuric & J.G. Khinast

    Analysis of large-scale tablet coating: Modeling, simulation and experiments.

    Eur. J. Pharm. Sci. 90 (2016) 14-24..

  • L. Perez-Gandarillas, A. Perez-Gago, A. Mazor, P. Kleinebudde, O. Lecoq & A. Michrafy

    Effect of roll-compaction and milling conditions on granules and tablet properties.

    Eur. J. Pharm. Biopharm. 106 (2016) 38-49..

  • R. Meier, M. Thommes, N. Rasenack, K.-P. Moll, M. Krumme & P. Kleinebudde

    Granule size distributions after twin-screw granulation - Do not forget the feeding systems.

    Eur. J. Pharm. Biopharm. 106 (2016) 59-69..

  • R. Dreu, G. Toschkoff, A. Funke, A. Altmeyer, K. Knop, J. Khinast & P. Kleinebudde

    Evaluation of the tablets’ surface flow velocities in pan coaters.

    Eur. J. Pharm. Biopharm. 106 (2016) 97-106..

  • P. Boehling, G. Toschkoff, S. Just, K. Knop, P. Kleinebudde, A. Funke, H. Rehbaum, P. Rajniak & J.G. Khinast,

    Simulation of a tablet coating process at different scales using DEM.

    Eur. J. Pharm. Sci. 93 (2016) 74-83..

  • A. Schmidt, H. de Waard, K.-P. Moll, M. Krumme & P. Kleinebudde

    Quantitative assessment of mass flow boudaries in continuous twin-screw granulation.

    Chimia 70 (2016) 604-609..

  • J. Quodbach & P. Kleinebudde

    A critical review on tablet disintegration.

    Pharm. Dev. Technol. 21 (2016) 763-774..

  • C.C. Sun & P. Kleinebudde

    Mini review: Mechanisms to the loss of tabletability by dry granulation.

    Eur. J. Pharm. Biopharm. 106 (2016) 9-14..

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2015

  • M.W. Tackenberg, R. Krauss, A. Marmann, M. Thommes, H.P. Schuchmann & P. Kleinebudde
    Encapsulation of liquids using a counter rotating twin screw extruder.
    Eur. J. Pharm. Biopharm. 89 (2015) 9-17.
  • G. Di Pretoro, L. Zema, A. Gazzaniga & P. Kleinebudde
    Impact of needle-like crystals on wet and solid-lipid extrusion processes.
    Powder Technol. 270 (2015) 476-483.
  • A. Dischinger, S. Page & P. Kleinebudde
    Fast dissolving fillers in dry foam formulation.
    Powder Technol. 270 (2015) 494-501.
  • M.W. Tackenberg, C. Geisthövel, A. Marmann, H.P. Schuchmann, P. Kleinebudde & M. Thommes
    Mechanistic study of carvacrol processing and stabilization as glassy solid solution and microcapsule.
    Int. J. Pharm. 487 (2015) 597-605.
  • J. Mosig & P. Kleinebudde
    Critical evaluation of root causes of the reduced compactability after roll compaction/ dry granulation.
    J. Pharm. Sci. 104 (2015) 1108-1118.
  • E. Lenz, A. Sprunk, P. Kleinebudde & S. Page
    Impact of fillers on dissolution kinetic of fenofibrate dry foams.
    Pharm. Dev. Technol. 20 (2015) 570-578.
  • J. Quodbach & P. Kleinebudde
    Performance of tablet disintegrants: Impact of storage conditions and relative tablet density.
    Pharm. Dev. Technol. 20 (2015) 762-768.
  • J. Ronowicz, M. Thommes, P. Kleinebudde & J. Krysinski
    A data mining approach to optimize pellets manufacturing process based on a decision tree algorithm
    Eur. J. Pharm. Sci. 73 (2015) 44-48.
  • C. Wörtz & P. Kleinebudde
    Development of orodispersible polymer films with focus on the solid-state characterization of crystalline loperamide.
    Eur. J. Pharm. Biopharm. 94 (2015) 52-63.
  • A. Mendyk, S. Güres, R. Jachowicz, J. Szlęk, S. Polak, B. Wiśniowska & P. Kleinebudde
    From heuristic to mathematical modeling of drugs dissolution profiles: application of artificial neural networks and genetic programming.
    Comp. Math. Meth. Med. 2015 (2015), Article ID 863874, 9 pages
  • M.W. Tackenberg, R. Krauss, H.P. Schuchmann & P. Kleinebudde
    Encapsulation of orange terpenes investigating a plasticization extrusion process.
    J. Microencaps. 32 (2015) 408-417.
  • C. Wörtz & P. Kleinebudde
    Development of orodispersible polymer films containing poorly water soluble Active Pharmaceutical Ingredients with focus on different drug loadings and storage stability.
    Int. J. Pharm. 493 (2015) 134-145.
  • M. Czajkowska, M. Sznitowska & P. Kleinebudde
    Determination of coating thickness of minitablets and pellets by dynamic image analysis.
    Int. J. Pharm. 495 (2015) 347-353.
  • E. Lenz, K. Tarp Jensen, L. Ingerslev Blaabjerg, K. Knop, H. Grohganz, K. Löbmann, T. Rades & P. Kleinebudde
    Solid-state properties and dissolution behaviour of tablets containing co-amorphous indomethacine-arginine.
    Eur. J. Pharm. Biopharm. 96 (2015) 44-52.
  • R. Meier, M. Thommes, N. Rasenack, M. Krumme, K.-P. Moll & P. Kleinebudde
    Simplified formulations with high drug loads for continuous twin-screw granulation.
    Int. J. Pharm. 496 (2015) 12-23.
  • G. Toschkoff, S. Just, K. Knop, P. Kleinebudde, A. Funke, A. Altmeyer, D. Djuric, G. Scharrer & J. Khinast
    Modeling of an active tablet coating process.
    J. Pharm. Sci. 104 (2015) 4082-4092.
  • M.W. Tackenberg & P. Kleinebudde
    Encapsulation of liquids via extrusion – A review.
    Curr. Pharm. Des. 21 (2015) 5815-5828.

 

2014

  • J. Quodbach, A. Moussavi, R. Tammer, J. Frahm & P. Kleinebudde
    Tablet disintegration studied by high-resolution real-time magnetic resonance imaging.
    J. Pharm. Sci. 103 (2014) 249-255.
  • M.W. Tackenberg, M. Thommes, H.P. Schuchmann & P. Kleinebudde
    Solid state of processed carbohydrate matrices from maltodextrin and sucrose.
    J. Food Eng. 129 (2014) 30-37.
  • M.W. Tackenberg, M. Thommes, H.P. Schuchmann & P. Kleinebudde
    Orange terpens, carvacrol and α-tocopherol encapsulated in maltodextrin and sucrose matrices via batch mixing.
    J. Food Eng. 135 (2014) 44-52.
  • É. Bölcskei, G. Regdon jr., T. Sovány, D. Ghanam, K. Knop, P. Kleinebudde & K. Pintye-Hódi
    Preparing of pellets by extrusion/spheronization using different types of equipment and process conditions.
    Drug Dev. Ind. Pharm. 40 (2014) 762-764.
  • J. Mosig & P. Kleinebudde
    Evaluation of lubrication methods: How to generate a comparable lubrication for dry granules and powder material for tableting processes.
    Powder Technol. 266 (2014) 156-166.
  • K. Nikowitz, F. Folttmann, M. Wirges, K. Knop, G. Regdon jr. & P. Kleinebudde
    Development of a Raman method to follow the evolution of coating thickness of pellets.
    Drug Dev. Ind. Pharm. 40 (2014) 1005-1010.
  • A. Fussell, C.J. Strachan, P. Kleinebudde & H. Offerhaus
    Coherent anti-Stokes Raman scattering (CARS) microscopy visualizes pharmaceutical tablets during dissolution.
    J. Vis. Exp. Issue 89 (2014) URL: www.jove.com/video/51847 DOI: doi:10.3791/51847
  • J. Quodbach, A. Moussavi, R. Tammer, J. Frahm & P. Kleinebudde
    Assessment of disintegrant efficacy with fractal dimensions from real-time MRI.
    Int J. Pharm. 475 (2014) 605-612.
  • C. Krüger, M. Thommes & P. Kleinebudde
    Influence of storage condition on properties of MCC II-based pellets with Theophylline-monohydrate.
    Eur. J. Pharm. Biopharm. 88 (2014) 483-491.
  • D. Brock, J.A. Zeitler, A. Funke, K. Knop & P. Kleinebudde
    Evaluation of critical process parameters for inter-tablet coating uniformity of active-coated GITS using terahertz pulsed imaging.
    Eur. J. Pharm. Biopharm. 88 (2014) 434-442.
  • J.Quodbach & P. Kleinebudde
    A new apparatus for real-time assessment of the particle size distribution of disintegrating tablets.
    J. Pharm. Sci. 103 (2014) 3657-3665.
  • J. Quodbach & P. Kleinebudde
    Systematic classification of tablet disintegrants by water uptake and force development kinetics.
    J. Pharm. Pharmacol. 66 (2014) 1429-1438.
  • F. Folttmann, K. Knop, P. Kleinebudde & M. Pein
    In-line spatial filtering velocimetry for particle size and film thickness determination in fluidized-bed pellet coating processes.
    Eur. J. Pharm. Biopharm. 88 (2014) 931-938.

 

2013

  • A. Fussell, E.T. Garbacik, C.J. Strachan, P. Kleinebudde & H. Offerhaus
    In situ dissolution analysis using coherent anti-Stokes Raman scattering (CARS) and hyperspectral CARS microscopy.
    Eur. J. Pharm. Biopharm. 85 (2013) 1141-1147.
  • Just, S., Toschkoff, G., Funke, A., Djuric, D., Scharrer, G., Khinast, J., Knop, K., Kleinebudde, P.
    Optimization of the inter-tablet coating uniformity for an active coating process at lab and pilot scale
    Int. J. Pharm. 457 (2013) 1-8.
  • Toschkoff, G., Just, S., Funke, A., Djuric, D., Knop, K., Kleinebudde, P., Scharrer, G., Khinast, J.G.
    Spray models for discrete element simulations of particle coating processes
    Chem. Eng. Sci. 101 (2013) 603-614.
  • Preis, M., Woertz, C., Kleinebudde, P., Breitkreutz, J.
    Oromucosal film preparations: Classification and characterization methods
    Expert Opinion on Drug Delivery 10 (2013) 1303-1317.
  • Brock, D., Zeitler, J.A., Funke, A., Knop, K., Kleinebudde, P.
    Evaluation of critical process parameters for intra-tablet coating uniformity using terahertz pulsed imaging
    Eur. J. Pharm. Biopharm. 85 (2013) 1122-1129.
  • Woertz, C., Preis, M., Breitkreutz, J., Kleinebudde, P.
    Assessment of test methods evaluating mucoadhesive polymers and dosage forms: An overview
    Eur. J. Pharm. Biopharm. 85 (2013) 843-853.
  • Krueger, C., Thommes, M., Kleinebudde, P.
    Influence of MCC II fraction and storage conditions on pellet properties
    Eur. J. Pharm. Biopharm. 85 (2013) 1039-1045.
  • Sprunk, A., Page, S., Kleinebudde, P.
    Influence of process parameters and equipment on dry foam formulation properties using indomethacin as model drug
    Int. J. Pharm. 455 (2013) 189-196.
  • Brock, D., Zeitler, J.A., Funke, A., Knop, K., Kleinebudde, P.
    Critical factors in the measurement of tablet film coatings using terahertz pulsed imaging
    J. Pharm. Sci. 102 (2013) 1813-1824.
  • Wirges, M., Funke, A., Serno, P., Knop, K., Kleinebudde, P.
    Development and in-line validation of a Process Analytical Technology to facilitate the scale up of coating processes
    J. Pharm. Biomed. Analysis 78-79 (2013) 57-64.
  • Krueger, C., Thommes, M., Kleinebudde, P.
    Spheronisation mechanism of MCC II-based pellets
    Powder Technol. 238 (2013) 176-187.
  • Knop, K., Kleinebudde, P.
    PAT-tools for process control in pharmaceutical film coating applications
    Int. J. Pharm. 457 (2013) 527-536
  • Wirges, M., Funke, A., Serno, P., Knop, K., Kleinebudde, P.
    Monitoring of an active coating process for two-layer tablets-model development strategies
    J. Pharm. Sci. 102 (2013) 556-564.
  • Just, S., Toschkoff, G., Funke, A., Djuric, D., Scharrer, G., Khinast, J., Knop, K., Kleinebudde, P.
    Experimental analysis of tablet properties for discrete element modeling of an active coating process
    AAPS PharmSciTech. 14 (2013) 402-411.

 


 2012

  • J. Sakwanichol, S. Puttipipatkhachorn, G. Ingenerf & P. Kleinebudde
    Roll compaction/ dry granulation: Possibility to use roll mill in dry granulation step.
    Pharm. Dev. Technol. 17 (2012) 30-39.

  • S. Güres, J. Siepmann, F. Siepmann & P. Kleinebudde
    Modeling dissolution from solid lipid extrudates containing hydrophilic components.
    Eur. J. Pharm. Biopharm. 80 (2012) 122-129.

  • R. Witzleb, A. Müllertz, V.-R. Kanikanti , H.-J. Hamann & P. Kleinebudde
    Dissolution of solid lipid extrudates including biorelevant media.
    Int. J. Pharm. 422 (2012) 116-124.

  • J. Müller, D. Brock, K. Knop, A. Zeitler & P. Kleinebudde
    Prediction of dissolution time and coating thickness of coated sustained release formulations using Raman spectroscopy and Terahertz Pulsed Imaging.
    Eur. J. Pharm. Biopharm. 80 (2012) 690-697.
  • A. Kalivoda, M. Fischbach & P. Kleinebudde
    Application of mixtures of polymeric carriers for dissolution enhancement of fenofibrate using hot-melt extrusion.
    Int. J. Pharm. 429 (2012) 58-68.
  • É. Bölcskei, G. Regdon jr., T. Sovány, P. Kleinebudde & K. Pintye-Hódi
    Optimization of preparation of matrix pellets containing Eudragit® NE 30D.
    Chem. Eng. Res. Design 90 (2012) 651-657.
  •  A. Kalivoda, M. Fischbach, M. Maio & P. Kleinebudde
    Preliminary studies to assess ultrasound-assisted compaction as a novel technique in solid dispersion preparation.
    Pharm. Ind. 74 (2012) 652-662.
  • S. Güres, A. Mendyk, R. Jachowicz & P. Kleinebudde
    Application of artificial neural networks (ANN) and genetic programming (GP) for prediction of drug release from solid lipid matrices.
    Int. J. Pharm. 436 (2012) 877-879.
  • J. Quodbach, J. Mosig & P. Kleinebudde
    Compaction behavior of isomalt after roll compaction.
    Pharmaceutics 4 (2012) 494-500.
  •  A. Kalivoda, M. Fischbach & P. Kleinebudde
    Application of mixtures of polymeric carriers for dissolution enhancement of oxeglitazar using hot-melt extrusion.
    Int. J. Pharm. 439 (2012) 145-156.
  •  L. Suhrenbrock, K. Knop, G. Radtke & P. Kleinebudde
    Pellet layering: Scale-up considerations using different kinds of processing equipment.
    Drug Dev. Ind. Pharm. 38 (2012) 1494-1503.

 


 2011

  • T. Kuntz, M.A. Schubert & P. Kleinebudde
    Increased compactability of acetames after roll compaction.
    Eur. J. Pharm. Biopharm. 77 (2011) 164-169.
  • R. Witzleb, V.-R. Kanikanti, H.-J. Hamann & P. Kleinebudde
    Solid lipid extrusion with small die diameters – Electrostatic charging, taste masking and continuous production.
    Eur. J. Pharm. Biopharm. 77 (2011) 170-177.
  • J. Albers, K. Matthée, K. Knop & P. Kleinebudde
    Prediction of solid dispersion formation to improve solubility of poorly soluble drugs.
    J. Pharm. Sci. 100 (2011) 667-680.
  • S. Zhong, Y.-C. Shen, L. Ho, R. May, J.A. Zeitler, M. Evans, P.T. Taday, M. Pepper, T. Rades, K.C. Gordon, R. Müller & P. Kleinebudde
    Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography.
    Opt. Laser Eng. 49 (2011) 361-365.
  • D. Ghanam & P. Kleinebudde
    Suitability of a flat die press for the manufacture of pharmaceutical pellets by extrusion/spheronization.
    Drug Dev. Ind. Pharm. 37 (2011) 456-464.
  • R. Witzleb, V.-R. Kanikanti, H.-J. Hamann & P. Kleinebudde
    Influence of drug particle shape on the solid lipid extrusion process.
    Powder Technol. 207 (2011) 407-413.
  • K. Wörtz, C. Tißen, P. Kleinebudde & J. Breitkreutz
    A comparative study on two electronic tongues for pharmaceutical formulation development.
    J. Pharm. Biomed. Anal. 55 (2011) 272-281.
  • D. Ghanam & P. Kleinebudde
    Suitability of -carrageenan pellets for the formulation of multiparticulate tablets with modified release.
    Int. J. Pharm. 409 (2011) 9-18.
  • L. Suhrenbrock, G. Radtke, K. Knop & P. Kleinebudde
    Suspension pellet layering using PVA-PEG graft copolymer as a new binder.
    Int. J. Pharm. 412 (2011) 28-36.
  • S. Güres & P. Kleinebudde
    Dissolution from solid lipid extrudates containing release modifiers.
    Int. J. Pharm. 412 (2011) 77-84.
  • C. Tißen, K. Wörtz, J. Breitkreutz & P. Kleinebudde
    Development of mini-tablets with 1 mm and 2 mm diameter.
    Int. J. Pharm. 416 (2011) 164-170.
  • M. Haaser, M. Windbergs, C.M. McGoverin, P. Kleinebudde, T. Rades, K.C. Gordon & C.J. Strachan
    Analysis of matrix dosage forms during dissolution testing using Raman microscopy.
    J. Pharm. Sci. 100 (2011) 4452-4459.
  • K. Wörtz, C. Tißen, P. Kleinebudde & J. Breitkreutz
    Development of a taste masked generic ibuprofen suspension – Top down approach guided by electronic tongue measurements.
    J. Pharm. Sci. 100 (2011).
  • D. Hasa, B. Perissutti, M. Grassi, M. Zacchigna, M. Pagotto, P. Kleinebudde & D. Voinovich
    Melt extruded helical waxy matices as a new sustained drug delivery system.
    Eur. J. Pharm. Biopharm. 79 (2011) 592-600.
  • M. Wirges, J. Müller, P. Kasa, G. Regdon, K. Pintye-Hódi, K. Knop & P. Kleinebudde
    From mini to micro scale – Feasibility of Raman spectroscopy as a PAT tool.
    Pharmaceutics 3 (2011) 723-730.
  • D. Gallardo, B. Skalsky & P. Kleinebudde
    Characterization of combinations between anionic-cationic poly(methyl methacrylate) copolymers.
    Pharm. Ind. 73 (2011) 1875-1884.

 


 2010

  • M. Windbergs, S. Güres, C.J. Strachan & P. Kleinebudde
    Two-step solid lipid extrusion as a process to modify dissolution behavior.
    AAPS PharmSciTech. 11(2010) 2-8.

  • K. Woertz, C. Tissen, P. Kleinebudde & J. Breitkreutz
    Qualification of an electronic tongue according to ICH guideline Q2.
    J. Pharm. Biomed. Anal. 51 (2010) 497-506.
  • M. Windbergs, M. Haaser, C. McGoverin, K. Gordon, P. Kleinebudde & C.J. Strachan
    Investigating the structure and dissolution behaviour of solid lipid extrudates using Raman spectroscopy and mapping.

    J. Pharm. Sci. 99 (2010) 1464-1475.
  • L. Ho, R. Müller, C. Krüger, K.C. Gordon, P. Kleinebudde, M. Pepper, T. Rades, Y.C. Shen, P.F. Taday & J.A. Zeitler
    Investigating dissolution performance critical areas on coated tablets: A case study using terahertz pulsed imaging.
    J. Pharm. Sci. 99 (2010) 392-402.
  • J. Müller, K. Knop, J. Thies, K. Uerpmann & P. Kleinebudde
    Feasibility of raman spectroscopy as PAT tool in active coating.
    Drug Dev. Ind. Pharm. 36 (2010) 234-243.
  • G. Baki, J. Bajdik, D. Djuric, K. Knop, P. Kleinebudde & K. Pintye-Hódi
    Role of surface free energy and spreading coefficient in the formulation of active agent-layered pellets.

    Eur. J. Pharm. Biopharm. 74 (2010) 324-331.
  • D. Ghanam, I. Hassan & P. Kleinebudde
    Compression behaviour of kappa-carrageenan pellets.
    Int. J. Pharm. 390 (2010) 117-127.
  • H. Yano & P. Kleinebudde
    Improvement of dissolution behavior for poorly water-soluble drug by application of cyclodextrin in extrusion process: Comparison between melt extrusion and wet extrusion.
    AAPS PharmSciTech 11 (2010) 885-893.
  • K. Kristó, J. Bajdik, P. Kleinebudde & K. Pintye-Hódi
    Effect of lubricant on spreading of coating liquid on surface of tablets containing pancreatin.
    Pharm. Dev. Technol. 15 (2010) 354-359.
  • C. Krüger, M. Thommes & P. Kleinebudde
    Suitability of microcrystalline cellulose II as new pelletisation aid for wet extrusion-spheronisation in comparison to microcrystallline cellulose I.
    J. Pharm. Innov. 5 (2010) 45-57.
  • J. Müller, K. Knop & P. Kleinebudde
    Validation of Raman spectroscopic procedures in agreement with ICH guideline Q2 with considering the transfer to real time monitoring of an active tablet coating process.

    J. Pharm. Biomed. Anal. 53 (2010) 884-894.
  • D. Djuric & P. Kleinebudde
    Continuous granulation with a twin-screw extruder: Impact of material throughput.

    Pharm. Dev. Technol. 15 (2010) 518-525.
  • K. Wörtz, C. Tißen, P. Kleinebudde & J. Breitkreutz
    Rational development of taste masked liquid formulations guided by an electronic tongue.
    Int. J. Pharm. 400 (2010) 114-123.
  • Mendyk, P. Kleinebudde, M. Thommes, A. Yoo, J. Szleogonnek, & R. Jachowicz
    Analysis of pellet properties with use of artificial neural networks.
    Eur. J. Pharm. Sci. 41 (2010) 421-429.

 


 2009

  • A. Dukic-Ott, M. Thommes, J.-P. Remon, P. Kleinebudde & C. Vervaet
    Production of pellets via extrusion/ spheronisation without the incorporation of microcrystalline cellulose: A critical review.

    Eur. J. Pharm. Biopharm. 71 (2009) 38-42.
  • M. Windbergs, C.J. Strachan & P. Kleinebudde
    Investigating the principles of recrystallzation from glyceride melts.
    AAPS PharmSciTech. 10 (2009) 1224-1233.
  • M. Jurna, M. Windbergs, C.J. Strachan, L. Hartsuiker, C. Otto, P. Kleinebudde, J.L. Herek & H.L. Offerhaus
    Development of a method using coherent anti-Stokes Raman Scattering microscopy to monitor drug dissolution in different oral pharmaceutical dosage forms.
    J. Innovative Optical Health Science 2 (2009) 37-43.
  • M. Thommes, D.R. Ely & P. Kleinebudde
    The water binding behavior of -carrageenan determined by three different methods.
    Pharm. Dev. Technol. 14 (2009) 249-258.
  • M. Windbergs, M. Jurna, H.L. Offerhaus, P. Kleinebudde & C.J. Strachan
    Visualization of the physicochemical structure of oral solid dosage forms and changes upon dissolution using coherent anti-Stokes Raman Scattering microscopy.
    Anal. Chem. 81 (2009) 2085-2091.
  • M. Windbergs, C.J. Strachan & P. Kleinebudde
    Influence of structural variations on drug release from lipid/ polyethylene glycol matrices.
    Eur. J. Pharm. Sci. 37 (2009) 555-562.
  • M. Windbergs, C.J. Strachan & P. Kleinebudde
    Tailor-made dissolution profiles by extruded matrices based on lipid/ polyethylene glycol mixtures.

    J. Contr. Rel. 137 (2009) 211-216.
  • M. Thommes, L. Baert, G. van´t Klooster, M. Geldof, L. Schueller, J. Rosier & P. Kleinebudde
    Improved bioavailability of darunavir by use of κ-carrageenan as pelletisation aid.
    Eur. J. Pharm. Biopharm. 72 (2009) 614-620.
  • H. Jaeda, K. Knop & P. Kleinebudde
    Powder flow measurement – Comparison between two ring shear testers.

    Pharm. Ind. 71 (2009) 1221-1228.
  • M. Windbergs, C.J. Strachan & P. Kleinebudde
    Influence of the composition of gylcerides on the solid-state behaviour and the dissolution profiles of solid lipid extrudates.
    Int. J. Pharm. 381 (2009) 184-191.
  • A. Yoo & P. Kleinebudde
    Spheronisation of small extrudates containing -carrageenan using two spheronizers.

    J. Pharm. Sci. 98 (2009) 3776-3787.
  • M. Windbergs, C.J. Strachan & P. Kleinebudde
    Understanding the solid-state behaviour of solid lipid extrudates and its influence on dissolution.

    Eur. J. Pharm. Biopharm. 71 (2009) 80-87.
  • L. Ho, R. Müller, K.C. Gordon, P. Kleinebudde, M. Pepper, T. Rades, Y.C. Shen, P.F. Taday & J.A. Zeitler
    Terahertz pulsed imaging as process analytical tool for sustained-release tablet film coating.
    Eur. J. Pharm. Biopharm. 71 (2009) 117-123.
  • D. Djuric, B. Van Melkebeke, P. Kleinebudde, J.P. Remon & C. Vervaet
    Comparison of two twin-screw extruders for continuous granulation.
    Eur. J. Pharm. Biopharm. 71 (2009) 155-160.
  • C. Reitz & P. Kleinebudde
    Spheronization of solid lipid extrudates.
    Powder Technol. 189 (2009) 238-244.
  • J. Albers, R. Alles, K. Matthée, K. Knop, J. Schulze Nahrup & P. Kleinebudde
    Mechanism of drug release from polymethacrylate-based extrudates and milled strands prepared by hot-melt extrusion.
    Eur. J. Pharm. Biopharm. 71 (2009) 387-394.

 


 2008

  • M. Thommes & P. Kleinebudde
    Comparison of different k-Carrageenans in pelletisation by extrusion/ spheronisation.
    Pharm. Dev. Technol. 13 (2008) 27-35.
  • L. Ho, R. Müller, K.C. Gordon, P. Kleinebudde, M. Pepper, T. Rades, Y.C. Shen, P.F. Taday & J.A. Zeitler
    Applications of terahertz pulsed imaging to sustained-release tablet film coating assessment and dissolution performance.

    J. Contr. Rel. 127 (2008) 79-87.
  • É. Bölcskei, J. Bajdik, J. Müller, K. Knop, P. Kleinebudde & K. Pintye-Hódi
    Pretreatment of pigments to prepare liquids for enteric coating.

    Die Pharmazie 63 (2008) 514-515. doi: 10.1691/ph.2008.8074.
  • M.H. Herting & P. Kleinebudde
    Studies on the reduction of tensile strength of tablets after roll compaction/ dry granulation.
    Eur. J. Pharm. Biopharm. 70 (2008) 372-379. doi: 10.1016/j.ejpb.2008.04.003.
  • J. Bajdik, G. Baki, Z. Szent-Királlyi, K. Knop, P. Kleinebudde & K. Pintye-Hódi
    Evaluation of the composition of the binder bridges in matrix granules prepared with a small-scale high-shear granulator.

    J. Pharm. Biomed. Anal. 48 (2008) 694-701.
  • C. Reitz, C.J. Strachan & P. Kleinebudde
    Solid lipid extrudates as sustained release matrices: The effect of surface structure on drug release properties.
    Eur. J. Pharm. Sci. 35 (2008) 335-343.
  • Michalk, H.-J. Hamann, R. Kanikanti & P. Kleinebudde
    Controlled release of active as a consequence of the die diameter in solid lipid extrusion.
    J. Contr. Rel. 132 (2008) 35-41.
  • D. Djuric & P. Kleinebudde
    Impact of screw elements in continuous granulation with a twin-screw extruder.

    J. Pharm. Sci. 97 (2008) 4934-4942. doi: 10.1002/jps.21339.
  • D. Gallardo, B. Skalsky & P. Kleinebudde
    Controlled release solid dosage forms using combinations of (meth)acrylate copolymers.
    Pharm. Dev. Technol. 13 (2008) 413-423.

 


 

 

2007

  • R. Müller & P. Kleinebudde
    Prediction of tablet velocity in pan coaters for scale-up.

    Powder Technol. 173 (2007) 51-58.
  • R. Müller & P. Kleinebudde
    Comparison of a laboratory and a production coating spray gun with respect to scale-up.

    AAPS PharmSciTech. 8 (2007) Article 3.
  • R. Müller & P. Kleinebudde
    Abrasion of tablets in a laboratory and a production perforated pan coater.
    Eur. J. Pharm. Biopharm. 67 (2007) 458-463.
  • N. Charoenthai, P. Kleinebudde & S. Puttipipatkhachorn
    Use of chitosan-alginate as alternative pelletisation aid to microcrystalline cellulose in extrusion/ spheronisation.

    J. Pharm. Sci. 96 (2007) 2469-2484.
  • N. Charoenthai, P. Kleinebudde & S. Puttipipatkhachorn
    Influence of chitosan type on the production and the properties of extruded pellets with low amount of microcrystalline cellulose.
    AAPS PharmSciTech 8 (2007) Article 64.
  • C. Reitz & P. Kleinebudde
    Solid lipid extrusion of sustained release dosage forms.
    Eur. J. Pharm. Biopharm. 67 (2007) 440-448.
  • C. Reitz & P. Kleinebudde
    Influence of thermal and thermo-mechanical treatment: Comparison of two lipids with respect to their suitability for solid lipid extrusion.
    J. Thermal Anal. Calorim. 89 (2007) 669-673.
  • M. Thommes, W. Blaschek & P. Kleinebudde
    Effect of drying on extruded pellets based on k-Carrageenan.
    Eur. J. Pharm. Sci. 31 (2007) 112-118.
  • M. Thommes & P. Kleinebudde
    Properties of pellets manufactured by wet extrusion/ spheronisation process using κ-carrageenan: Effect of process parameters.
    AAPS PharmSciTech 8 (2007) 4: article 95.
  • M.H. Herting & P. Kleinebudde
    Roll compaction/dry granulation: Effect of raw material particle size on granule and tablet properties.
    Int. J. Pharm. 338 (2007) 110-118.
  • M.H. Herting, K. Klose & P. Kleinebudde
    Comparison of different binders for roll compaction/ dry granulation.
    Pharm. Dev. Technol. 12 (2007) 525-532.
  • L. Ho, R. Müller, M. Römer, K.C. Gordon, J. Heinämäki, P. Kleinebudde, M. Pepper, T. Rades, Y.C. Shen, C.J. Strachan, P.F. Taday, J.A. Zeitler
    Analysis of sustained-release tablet film coats using terahertz pulsed imaging.

    J. Contr. Rel. 119 (2007) 253-261.

 


 2006

  • S. Page, K.-H. Baumann & P. Kleinebudde
    Mathematical modeling of an aqueous film coating process in a Bohle Lab-Coater. Part I. Development of the model.
    AAPS PharmSciTech. 7 (2006) Article 42.
  • S. Page, K.-H. Baumann & P. Kleinebudde
    Mathematical modeling of an aqueous film coating process in a Bohle Lab-Coater. Part II. Application of the model.
    AAPS PharmSciTech. 7 (2006) Article 43.
  • R. Müller & P. Kleinebudde
    Influence of scale-up on the abrasion of tablets in a pan coater.
    Eur. J. Pharm. Biopharm. 64 (2006) 388-392.
  • R. Müller & P. Kleinebudde
    Comparison study of laboratory and production spray guns in film coating: Effect of pattern air and nozzle diameter.
    Pharm. Dev. Technol. 11 (2006) 425-433.
  • J. Albers, K. Knop & P. Kleinebudde
    Brand-to-brand and batch-to-batch uniformity of microcrystalline cellulose in direct tableting with a pneumohydraulic tablet press.
    Pharm. Ind. 68 (2006) 1420-1428.
  • M. Thommes & P. Kleinebudde
    Use of k-carrageenan as alternative pelletisation aid to microcrystalline cellulose in extrusion/spheronisation. I. Influence of type and fraction of filler.
    Eur. J. Pharm. Biopharm. (2006) 59-67.
  • M. Thommes & P. Kleinebudde
    Use of k-carrageenan as alternative pelletisation aid to microcrystalline cellulose in extrusion/spheronisation. II. Influence of drug and filler type.
    Eur. J. Pharm. Biopharm. (2006) 68-75.

 


 2005

  • R. Müller & P. Kleinebudde
    Scale-down experiments in a new type of pan coater.

    Pharm. Ind. 67 (2005) 950-957.
  • F. Freitag, J. Runge & P. Kleinebudde
    Co-processing of powdered cellulose and magnesium carbonate: Direct tableting vs. tableting after roll compaction/ dry granulation.
    Pharm. Dev. Technol. 10 (2005) 353-362.
  • P.M. Fechner, S. Wartewig, A. Kiesow, A. Heilmann, P. Kleinebudde & R.H.H. Neubert
    Interaction of water with different substituted cellulose ethers: A Raman spectroscopy and Environmental Scanning Electron Microscopy study.

    J. Pharm. Pharmacol. 57 (2005) 689-698.
  • Tho, S.A. Sande & P. Kleinebudde
    Cross-linking of amidated low-methoxylated pectin with calcium during extrusion/spheronisation: Effects on particle size and shape.

    Chem. Eng. Sci. 60 (2005) 3899-3907.
  • Claviez, M. Bornhöft, C.-J. Partsch, U. Heimann, W. Marg, P. Kleinebudde & M. Suttorp
    Hyponatriämie bei Säuglingen und Kleinkindern. Substitutionstherapie mit mikroverkapseltem, geschmacksneutralem Kochsalz.
    Monatsschrift für Kinderheilkunde 135 (2005) 145-149.
  • M.Bornhöft, M. Thommes & P. Kleinebudde
    Preliminary assessment of carrageenan as excipient for extrusion/spheronisation

    Eur. J. Pharm. Biopharm. 59 (2005) 127-131.

 


 2004

  • F. Freitag, K. Reincke, J. Runge, W. Grellmann & P. Kleinebudde
    How do roll compaction/ dry granulation affect the tableting behaviour of inorganic materials? Microhardness of ribbons and mercury porosimetry measurements of tablets.
    Eur. J. Pharm. Sci. 22 (2004) 325-333.
  • R. Grulke, P. Kleinebudde & G. Shlieout
    Mixture experiments on roll compaction. Part I and II.
    Pharm. Ind. 66 (2004) 794-796 und 911-915.
  • P. Kleinebudde
    Roll compaction/ dry granulation: Pharmaceutical applications.
    Eur. J. Pharm. Biopharm. 58 (2004) 317-326.

 


 2003

  • S. Tobiska & P. Kleinebudde
    Coating uniformity: Influence of atomizing air pressure.
    Pharm. Dev. Technol. 8 (2003) 39-46.
  • S. Tobiska & P. Kleinebudde
    Coating uniformity and coating efficiency in a Bohle-Lab-Coater using oval tablets.
    Eur. J. Pharm. Biopharm. 56 (2003) 3-9.
  • F. Freitag & P. Kleinebudde
    How do roll compaction/ dry granulation affect the tableting behaviour of anorganic materials? Comparison of four magnesium carbonates.

    Eur. J. Pharm. Sci. 19 (2003) 281-289.
  • J. Breitkreutz, M. Bornhöft, F. Wöll & P. Kleinebudde
    Pediatric drug formulations of sodium benzoate: I. Coated granules with a hydrophilic binder.
    Eur. J. Pharm. Biopharm. 56 (2003) 247-253.
  • J. Breitkreutz, F. El-Saleh, C. Kiera, P. Kleinebudde & W. Widey
    Pediatric drug formulations of sodium benzoate: II. Coated granules with a lipophilic binder.
    Eur. J. Pharm. Biopharm. 56 (2003) 255-260.
  • Tho, S.A. Sande & P. Kleinebudde
    Disintegrating pellets from a water-insoluble pectin derivative produced by extrusion/ spheronisation.
    Eur. J. Pharm. Biopharm. 56 (2003) 371-380.
  • P.M. Fechner, S. Wartewig, M. Füting, A. Heilmann, R.H.H. Neubert & P. Kleinebudde
    Comparison of microcrystalline cellulose and powdered cellulose before and after extrusion/ spheronization by FT-Raman spectroscopy and ESEM.
    PharmSci 5 (2003) article 32 (undefinedhttp://www.aapspharmsci.org/).
  • F. Wöll & P. Kleinebudde
    Charakterisierung der Porosität von Schülpen: Stanzmethode und NIRS-Methode.
    Chem.-Ing. Tech. 75 (2003) 1756-1759.
  • F. Freitag & P. Kleinebudde
    Walzenkompaktieren und Trockengranulieren pharmazeutischer Hilfsstoffe am Beispiel von Magnesiumcarbonat.
    Chem.-Ing. Tech. 75 (2003) 1760-1763.

 


 2002

  • A. Sieg, K. Held, U. Redeker & P. Kleinebudde
    Dissolution testing of reworked tablets.
    Pharm. Tech. Eur. 14 (2002) Jan 20-25.
  • I. Tho, S.A. Sande & P. Kleinebudde
    Pectinic acid, a novel excipient for production of pellets by extrusion/spheronisation: preliminary studies.
    Eur. J. Pharm. Biopharm. 54 (2002) 95-99.
  • I. Tho, E. Anderssen, K. Dyrstad, P. Kleinebudde & S.A. Sande
    Quantum chemical descriptors in the formulation of pectin pellets produced by extrusion/ spheronisation.
    Eur. J. Pharm. Sci. 16 (2002) 143-149.
  • M. Husmann, S. Schenderlein, M. Lück, H. Lindner & P. Kleinebudde
    Investigation of polymer erosion in microparticles produced by phase separation.
    Int. J. Pharm. 242 (2002) 277-280.
  • G. Shlieout, R.L. Lammens, P. Kleinebudde & M. Bultmann
    Dry granulation with a roller compactor. Part II: Evaluating the operation modes.
    Pharm. Tech. Eur. 14 (2002) Sep 32-39.
  • J. Kristensen, P. Kleinebudde & T. Schæfer
    Development of fast disintegrating pellets in a rotary processor.
    Drug Dev. Ind. Pharm. 28 (2002) 1201-1212.
  • J. Breitkreutz, P. Kleinebudde & J. Boos
    Kindgerechte Darreichungsformen – Arzneimitteltherapie für alle
    Pharm. Ztg. 147 (2002) 3210-3218.

 


 2001

  • R. Thies & P. Kleinebudde
    Melt pelletization of a hygroscopic drug in a high shear mixer. Part III: Effects of binder variation.
    Chem. Pharm. Bull. 49 (2001) 140-146.
  • S. Tobiska & P. Kleinebudde
    A simple method for evaluating the mixing efficiency of a new type of pan coater.
    Int. J. Pharm. 224 (2001) 141-149.
  • I. Tho, P. Kleinebudde & S.A. Sande
    Extrusion/spheronisation of pectin based formulations. I. Screening of important factors.
    AAPS PharmSciTech 2 (4) (2001) article 26 (undefinedhttp://www.pharmscitech.com).
  • I. Tho, P. Kleinebudde & S.A. Sande
    Extrusion/spheronisation of pectin based formulations. II. Effect of additive concentration in the granulation liquid.
    AAPS PharmSciTech 2 (4) (2001) article 27 (undefinedhttp://www.pharmscitech.com).
  • N. Meyer, K. Nestler, L. Engisch, G. Marx, M. Füting, A. Kiesow, A. Heilmann, S. Wartewig & P. Kleinebudde
    Raman spectroscopic surface characterization of cellulose derivatives.
    Fresen. J. Anal. Chem. 370 (2001) 789-791.

 


 2000

  • R. Thies & P. Kleinebudde
    Melt pelletisation of a hygroscopic drug in a high shear mixer. Part II: Mutual compensation of influence variables.
    Eur. J. Pharm. Sci. 10 (2000) 103-110.
  • J. Kristensen, T. Schæfer & P. Kleinebudde
    Direct pelletization in a rotary processor. I: Influence of process variables.
    Pharm. Dev. Technol. 5 (2000) 247-256.
  • M. Jumaa, F. El Saleh, I. Hassan, B. W. Müller & P. Kleinebudde
    Influence of cellulose type on the properties of extruded pellets.
    Part I: Physicochemical characterization of the cellulose types after homogenization.

    Colloid Polym. Sci. 278 (2000) 597-607.
  • P. Kleinebudde, M. Jumaa & F. El Saleh
    Influence of degree of polymerization on behaviour of cellulose during homogenization and extrusion/ spheronization.
    AAPS PharmSci 2 (2) (2000) article 21 (undefinedhttp://www.pharmsci.org/).
  • J. Kristensen, P. Kleinebudde & T. Schæfer
    Direct pelletization in a rotary processor controlled by torque measurements.
    II: Effects of changes in the content of microcrystalline cellulose.
    AAPS PharmSci 2 (3) (2000) article 24 (undefinedhttp://www.pharmsci.org/).
  • F. El Saleh, M. Jumaa, I. Hassan & P. Kleinebudde
    Influence of cellulose type on the properties of extruded pellets. Part II: Production and properties of pellets.
    S.T.P. Pharma Sciences 10 (2000) 379-385.
  • G. Shlieout, R.L. Lammens & P. Kleinebudde
    Dry granulation with a roller compactor. Part I: The functional units and operation modes.
    Pharm. Tech. Eur. 12 (2000) Nov. 24-35.
  • T. Wagner, F. Balszuweit & P. Kleinebudde
    Eine neue Methode zur Charakterisierung der spezifischen Oberfläche von Pellets mittels Flachbettscanner und Bildanalyse.
    Pharm. Ind. 62 (2000) 985-991.

 


 vor 2000

  • C. Schmidt & P. Kleinebudde
    Influence of the granulation step on pellets prepared by extrusion/ spheronization.
    Chem. Pharm. Bull. 47 (1999) 405-412.
  • P. Kleinebudde, M. Schröder, P. Schultz, B. W. Müller, T. Waaler & L. Nymo
    Importance of the fraction of microcrystalline cellulose and spheronization speed on the properties of extruded pellets made from binary mixtures.
    Pharm. Dev. Technol. 4 (1999) 397-404.
  • M. Jumaa, P. Kleinebudde & B. W. Müller
    Physicochemical properties and hemolytic effect of different lipid emulsion formulations using a mixture of emulsifiers.
    Acta Pharm. Helv. 73 (1999) 293-301.
  • A. Claviez, R. Thies, P. Kleinebudde & M. Suttorp
    Microencapsulated NaCl for oral salt-replacement therapy in infants.
    J. Natl. Cancer I. 91 (1999) 1513-1514.
  • R. Thies & P. Kleinebudde
    Melt pelletisation of a hygroscopic drug in a high shear mixer. Part I: Influence of process variables.
    Int. J. Pharm. 188 (1999) 131-143.

 


 1998

  • C. Schmidt & P. Kleinebudde
    Comparison between a twin-screw extruder and a rotary ring die press. Part II: Influence of process variables.
    Eur. J. Pharm. Biopharm. 45 (1998) 173-179.
  • M. Jumaa, P. Kleinebudde & B. W. Müller
    Mixture experiments with the oil phase of parenteral emulsions.
    Eur. J. Pharm. Biopharm. 46 (1998) 161-167.
  • F. El Saleh & P. Kleinebudde
    Mercury-free determination of apparent density and porosity of pellets by powder pycnometry.
    Pharm. Tech. Europe 10 (1998) Nov. 18-26.

 


  1997

  • F. Ruchatz, P. Kleinebudde & B. W. Müller
    Residual solvents in biodegradable microparticles. Influence of process parameters on the residual solvent in microparticles produced by the Aerosol Solvent Extraction System (ASES) process.
    J. Pharm. Sci. 86 (1997) 101-105.
  • P. Schultz & P. Kleinebudde
    A new multiparticulate delayed release system. Part I: Dissolution properties and release mechanism.
    J. Contr. Rel. 47 (1997) 181-189.
  • P. Schultz, I. Tho & P. Kleinebudde
    A new multiparticulate delayed release system. Part II: Coating formulation and properties of free films.
    J. Contr. Rel. 47 (1997) 191-199.
  • P. Kleinebudde
    The crystallite-gel-model for microcrystalline cellulose in wet-granulation, extrusion and spheronization.
    Pharm. Res. 14 (1997) 804-809.
  • C. Schmidt, H. Lindner & P. Kleinebudde
    Comparison between a twin-screw extruder and a rotary ring die press.
    Part I: Influence of formulation variables.

    Eur. J. Pharm. Biopharm. 44 (1997) 169-176.

 


 1996

  • F. Ruchatz, P. Kleinebudde & B. W. Müller
    Residual solvents in biodegradable microparticles: determination by a dynamic headspace gas chromatographic method.
    Int. J. Pharm. 142 (1996) 67-73.

 


 1995

  • P. Schultz & P. Kleinebudde
    Determination of pellet friability by use of an air stream apparatus.
    Pharm. Ind. 57 (1995) 323-328.
    Drugs made in Germany 39 (1996) 53-58.
  • P. Kleinebudde
    Use of a power-consumption-controlled extruder in the development of pellet formulations.
    J. Pharm. Sci. 84 (1995) 1259-1264.
  • M. Schröder & P. Kleinebudde
    Development of disintegrating pellets obtained from extrusion / spheronization.
    Pharmaceutical Science 1 (1995) 415-418.
  • M. Schröder & P. Kleinebudde
    Structure of disintegrating pellets with regard to fractal geometry.
    Pharm. Res. 12 (1995) 1694-1700.
  • M. Schröder & P. Kleinebudde
    Influence of formulation parameters on dissolution of propyphenazone pellets.
    Eur. J. Pharm. Biopharm. 41 (1995) 382-387.

 


 1994

  • H. Lindner & P. Kleinebudde
    Use of powdered cellulose for the production of pellets by extrusion/ spheronization.
    J. Pharm. Pharmacol. 46 (1994) 2-7.
  • D. Cordes, P. Kleinebudde & B. W. Müller
    Bestimmung der Konsistenz halbfester Zubereitungen mit dem Texture Analyser.
    Pharmazie 49 (1994) 180-182.
  • J. Bleich, P. Kleinebudde & B. W. Müller
    Influence of gas density and pressure on microparticles produced with the ASES process.
    Int. J. Pharm. 106 (1994) 77-84.
  • T. K. Bock, J.-S. Lucks, P. Kleinebudde, R. H. Müller & B. W. Müller
    High pressure homogenization of parenteral fat emulsions - Influence of process parameters on emulsion quality.
    Eur. J. Pharm. Biopharm. 40 (1994) 157-160.
  • P. Kleinebudde, A. J. Sølvberg & H. Lindner
    The power-consumption-controlled extruder: a tool for pellet production.
    J. Pharm. Pharmacol. 46 (1994) 542-546.
  • P. Kleinebudde
    Shrinking and swelling properties of pellets containing microcrystalline cellulose and low substituted hydroxypropylcellulose. Part I: Shrinking properties.
    Int. J. Pharm. 109 (1994) 209-219.
  • P. Kleinebudde
    Shrinking and swelling properties of pellets containing microcrystalline cellulose and low substituted hydroxypropylcellulose. Part II: Swelling properties.
    Int. J. Pharm. 109 (1994) 221-227.

 


 1993

  • P. Kleinebudde & H. Lindner
    Experiments with an instrumented twin-screw extruder using a single step granulation/ extrusion process.
    Int. J. Pharm. 94 (1993) 49-58.
  • H. Lindner & P. Kleinebudde
    Anwendung der automatischen Bildanalyse zur Charakterisierung von Pellets.
    Pharm. Ind. 55 (1993) 694-701.
  • P. Kleinebudde
    Application of low substituted hydroxypropylcellulose (L-HPC) in the production of pellets using extrusion/ spheronization.
    Int. J. Pharm. 96 (1993) 119-128.

 


 1990

  • B. W. Müller, P. Kleinebudde, T. Østberg & T. Waaler
    Untersuchungen des Einflusses von Teilchengrößen und Additiva auf das Sedimentationsverhalten von Suspensionen mit Hilfe einer Sedimentationswaage.
    Pharm. Ind. 52 (1990) 1267-1271.
  • B. W. Müller & P. Kleinebudde
    Untersuchungen an sogenannten Mikroemulsionssystemen
    1. Teil: Untersuchungen an arzneistofffreien Systemen.

    Pharm. Ind. 50 (1988) 370-375.
  • B. W. Müller & P. Kleinebudde
    Untersuchungen an sogenannten Mikroemulsionssystemen
    2. Teil: Untersuchungen an arzneistoffhaltigen Systemen.

    Pharm. Ind. 50 (1988) 1301-1306.
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